Journal
CHEMICAL SCIENCE
Volume 4, Issue 9, Pages 3427-3431Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc50811k
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Funding
- NIHGMS [RO1 GM073932]
- Ministerio de Economia y Competitividad, Spain
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The enantioselective bromocyclization of allenes is accomplished through the use of a chiral dinuclear gold complex and/or chiral phosphate anions in the presence of an N-bromolactam as an electrophilic bromine source. This method provides access to heterocyclic vinyl bromides with an allylic stereocenter in excellent yield and enantioselectivity. These enantioenriched vinyl bromides may serve as a handle for further derivatization via cross-coupling reactions.
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