Journal
CHEMICAL SCIENCE
Volume 3, Issue 6, Pages 1835-1838Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc20141k
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Funding
- National Institutes of Health [GM58877]
- National Science Foundation [CHE-0316689]
- Royal Society
- University of Liverpool
- GlaxoSmithKline
- EPSRC
- AstraZeneca
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A highly enantioselective rhodium-catalyzed allylic alkylation of acyclic alpha-alkoxy aryl ketones utilizing the complex derived from Wilkinson's catalyst and the chiral monodentate phosphite, BINOL-MeOP, has been developed. This process represents the first enantioselective rhodium-catalyzed allylic substitution with a prochiral nucleophile. The ability to transform the aryl ketones into the corresponding alcohol and ester illustrates the potential utility of this transformation for target directed synthesis.
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