Journal
CHEMICAL SCIENCE
Volume 3, Issue 5, Pages 1640-1644Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc00663d
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Funding
- NSERC
- CIHR
- CHRP
- Dalhousie University
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Growth of Streptomyces venezuelae ISP5230 with O-propargyl-L-serine led to the efficient production of an alkyne-containing jadomycin. The installed alkyne functionality provided a uniquely reactive handle within the natural product and was subsequently reacted with a series of azides to afford an eight-member library of jadomycin triazoles. The compounds were evaluated for their DNA cleavage, antibacterial and cytotoxic properties.
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