Alkynes as an eco-compatible “on-call” functionality orthogonal to biological conditions in water

Towards the Preparation of Novel Re/99mTc Tricarbonyl-Containing Peptide Nucleic Acid Bioconjugates

(2011) Gilles Gasser et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

The Development of Catalytic Nucleophilic Additions of Terminal Alkynes in Water†

(2010) Chao-Jun Li   ACCOUNTS OF CHEMICAL RESEARCH

An Unexpected Example of Protein-Templated Click Chemistry

(2010) Takayoshi Suzuki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclative Cleavage through Dipolar Cycloaddition: Polymer-Bound Azidopeptidylphosphoranes Deliver Locked cis-Triazolylcyclopeptides as Privileged Protein Binders

(2010) Ahsanullah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry

(2010) Vu Hong et al.   BIOCONJUGATE CHEMISTRY

Copper-Free Click Chemistry for Highly Luminescent Quantum Dot Conjugates: Application toin VivoMetabolic Imaging

(2010) Aude Bernardin et al.   BIOCONJUGATE CHEMISTRY

General Method for Labeling siRNA by Click Chemistry with Fluorine-18 for the Purpose of PET Imaging

(2010) Frédéric Mercier et al.   BIOCONJUGATE CHEMISTRY

Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

(2010) Ishwar Singh et al.   CHEMICAL COMMUNICATIONS

Kinetic target-guided synthesis

(2010) Xiangdong Hu et al.   CHEMICAL SOCIETY REVIEWS

In situ click chemistry: probing the binding landscapes of biological molecules

(2010) Sreeman K. Mamidyala et al.   CHEMICAL SOCIETY REVIEWS

Tricks with clicks: modification of peptidomimetic oligomers via copper-catalyzed azide-alkyne [3 + 2] cycloaddition

(2010) Justin M. Holub et al.   CHEMICAL SOCIETY REVIEWS

Click chemistry with DNA

(2010) Afaf H. El-Sagheer et al.   CHEMICAL SOCIETY REVIEWS

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology

(2010) Thomas J. Bandy et al.   CHEMICAL SOCIETY REVIEWS

Fe3O4 nanoparticles: a robust and magnetically recoverable catalyst for three-component coupling of aldehyde, alkyne and amine

(2010) Tieqiang Zeng et al.   GREEN CHEMISTRY

Cross-Linked DNA Generated by “Bis-click” Reactions with Bis-functional Azides: Site Independent Ligation of Oligonucleotides via Nucleobase Alkynyl Chains

(2010) Suresh S. Pujari et al.   JOURNAL OF ORGANIC CHEMISTRY

Difluorobenzocyclooctyne: Synthesis, Reactivity, and Stabilization by β-Cyclodextrin

(2010) Ellen M. Sletten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tailored Ligand Acceleration of the Cu-Catalyzed Azide−Alkyne Cycloaddition Reaction: Practical and Mechanistic Implications

(2010) Stanislav I. Presolski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gold-Catalyzed Three-Component Tandem Process: An Efficient and Facile Assembly of Complex Butenolides from Alkynes, Amines, and Glyoxylic Acid

(2010) Qiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Late-Stage Fluorination

(2010) Pingping Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorination made easier

(2010) Tobias Ritter   NATURE

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conjugation of an oligonucleotide to Tat, a cell-penetrating peptide, via click chemistry

(2010) Sarah D. Brown et al.   TETRAHEDRON LETTERS

Metal-Free, Regioselective Triazole Ligations that Deliver LockedcisPeptide Mimetics

(2009) Ahsanullah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformationally Homogeneous Heterocyclic Pseudotetrapeptides as Three-Dimensional Scaffolds for Rational Drug Design: Receptor-Selective Somatostatin Analogues

(2009) John M. Beierle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides

(2009) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules

(2009) Michael D. Best   BIOCHEMISTRY

Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids

(2009) Emine Kaya et al.   CHEMBIOCHEM

A macrocyclic coumarin-containing tripeptide via CuAAC chemistry

(2009) Sander S. van Berkel et al.   CHEMICAL COMMUNICATIONS

Sonogashira and “Click” reactions for the N-terminal and side-chain functionalization of peptides with [Mn(CO)3(tpm)]+-based CO releasing molecules (tpm = tris(pyrazolyl)methane)

(2009) Hendrik Pfeiffer et al.   DALTON TRANSACTIONS

CuI-Catalyzed Azide–Alkyne Intramoleculari-to-(i+4) Side-Chain-to-Side-Chain Cyclization Promotes the Formation of Helix-Like Secondary Structures

(2009) Mario Scrima et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry

(2009) Tomoyasu Hirose et al.   JOURNAL OF ANTIBIOTICS

Chemoenzymatic Synthesis of a New Class of Macrocyclic Oligosaccharides

(2009) Saddam Muthana et al.   JOURNAL OF ORGANIC CHEMISTRY

Peptide Cyclization and Cyclodimerization by CuI-Mediated Azide−Alkyne Cycloaddition

(2009) Reshma Jagasia et al.   JOURNAL OF ORGANIC CHEMISTRY

Genetic Encoding and Labeling of Aliphatic Azides and Alkynes in Recombinant Proteinsviaa Pyrrolysyl-tRNA Synthetase/tRNACUAPair and Click Chemistry

(2009) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Labeling of an Antisense Oligonucleotide with [18F]FPy5yne

(2009) James A. H. Inkster et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Clickable fluorophores for biological labeling—with or without copper

(2009) Péter Kele et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of N-Terminally Linked Protein Dimers and Trimers by a Combined Native Chemical Ligation-CuAAC Click Chemistry Strategy

(2009) Junpeng Xiao et al.   ORGANIC LETTERS

Benzyne Click Chemistry with in Situ Generated Aromatic Azides

(2009) Fengzhi Zhang et al.   ORGANIC LETTERS

Click–Click–Click: Single to Triple Modification of DNA

(2008) Philipp M. E. Gramlich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Modification ofCandida antarcticaLipase B via Residue-Specific Incorporation of a Non-Canonical Amino Acid

(2008) Sanne Schoffelen et al.   BIOCONJUGATE CHEMISTRY

DNA with Branched Internal Side Chains: Synthesis of 5-Tripropargylamine-dU and Conjugation by an Azide-Alkyne Double Click Reaction

(2008) Venkata Ramana Sirivolu et al.   CHEMBIOCHEM

Rapid and Efficient DNA Strand Cross-Linking by Click Chemistry

(2008) Petr Kočalka et al.   CHEMBIOCHEM

Molecular Imaging with PET

(2008) Simon M. Ametamey et al.   CHEMICAL REVIEWS

Base-Modified DNA Labeled by [Ru(bpy)3]2+ and [Os(bpy)3]2+ Complexes: Construction by Polymerase Incorporation of Modified Nucleoside Triphosphates, Electrochemical and Luminescent Properties, and Applications

(2008) Milan Vrábel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Backbone Amide Linker Strategy for the Synthesis of 1,4-Triazole-Containing Cyclic Tetra- and Pentapeptides

(2008) Jasper Springer et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Lipid-Conjugated Oligonucleotides via “Click Chemistry” Efficiently Inhibit Hepatitis C Virus Translation

(2008) Guilhem Godeau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triazole-Linked Dumbbell Oligodeoxynucleotides with NF-κB Binding Ability as Potential Decoy Molecules

(2008) Masanori Nakane et al.   JOURNAL OF ORGANIC CHEMISTRY

Gold(III) (C^N) complex-catalyzed synthesis of propargylamines via a three-component coupling reaction of aldehydes, amines and alkynes

(2008) Vanessa Kar-Yan Lo et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

A Straightforward Synthesis of Tetrameric Estrone-Based Macrocycles

(2008) Pedro Ramírez-López et al.   ORGANIC LETTERS

Benzyne Click Chemistry: Synthesis of Benzotriazoles from Benzynes and Azides

(2008) Feng Shi et al.   ORGANIC LETTERS

The Synthesis and Chelation Chemistry of DOTA−Peptide Conjugates

(2007) Luis M. De León-Rodríguez et al.   BIOCONJUGATE CHEMISTRY

Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne−Azide “Click” Reaction

(2007) Frank Seela et al.   BIOCONJUGATE CHEMISTRY

Synthesis of Modified DNA by PCR with Alkyne-Bearing Purines Followed by a Click Reaction

(2007) Philipp M. E. Gramlich et al.   ORGANIC LETTERS