Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 7, Pages 1198-1203Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb02096k
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Funding
- National Basic Research Program of China (973 Program) [2012CB825803, 2013CB932702]
- National Natural Science Foundation of China [51422207, 51132006, 21471106]
- Specialized Research Fund for the Doctoral Program of Higher Education [20123201110018]
- Suzhou Planning Project of Science and Technology [ZXG2012028]
- Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Collaborative Innovation Center of Suzhou Nano Science and Technology
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In this study, we provide the quantitative data on the membrane permeability of a HeLa cell in the presence of different sizes of SiO2 nanoparticles (NPs, 50, 100 and 200 nm). SiO2 NPs have low cytotoxicity, but 50 and 100 nm SiO2 NPs can increase the cell membrane permeability (a reversible effect) by 12.5% (0.02 mg mL(-1), 4 min) and 9% (0.02 mg mL(-1), 6 min), respectively. However, the 200 nm SiO2 NPs cannot affect the cell membrane permeability.
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