Journal
JACC-CARDIOVASCULAR IMAGING
Volume 6, Issue 12, Pages 1327-1341Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcmg.2013.09.014
Keywords
aneurysm; atherosclerosis; heart failure; molecular imaging; myocardial infarction; thrombosis; valvular disease; vascular injury
Funding
- National Institutes of Health [R01 HL108229]
- American Heart Association Scientist Development [0830352N]
- NIH [T32 HL007374]
- Abbott Vascular, Merck Co.
- Kowa Company, Ltd.
- [13GRNT1760040]
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Molecular imaging seeks to unravel critical molecular and cellular events in living subjects by providing complementary biological information to current structural clinical imaging modalities. In recent years, molecular imaging efforts have marched forward into the clinical cardiovascular arena, and are now actively illuminating new biology in a broad range of conditions, including atherosclerosis, myocardial infarction, thrombosis, vasculitis, aneurysm, cardiomyopathy, and valvular disease. Development of novel molecular imaging reporters is occurring for many clinical cardiovascular imaging modalities (positron emission tomography, single-photon emission computed,tomography, magnetic resonance imaging), as well as in translational platforms such as intravascular fluorescence imaging. The ability to image, track, and quantify molecular biomarkers in organs not routinely amenable to biopsy (e.g., the heart and vasculature) open new clinical opportunities to tailor therapeutics based on a cardiovascular disease molecular profile. In addition, molecular imaging is playing an increasing role in atherosclerosis drug development in phase II clinical trials. Here, we present state-of-the-art clinical cardiovascular molecular imaging strategies, and explore promising translational approaches positioned for clinical testing in the near term.(C) 2013 by the American College of Cardiology Foundation
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