Article
Agricultural Engineering
Hao Li, Hongda Yang, Jingjing Du, Zhiying Wang, Xiufang Wen, Jing Fang
Summary: This study found that lignin obtained from corncobs can be used to prepare thermo-sensitive hydrogel for the enrichment of biobutanol, which has high adsorption capacity and unique desorption performance. The lignin-based hydrogel showed high adsorption capacity, fast adsorption rate, and low energy consumption for desorption, providing a promising solution for the enrichment of low-concentration biofuels obtained through biological fermentation.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Fatema Rahman, Imin Wushur, Nabin Malla, Ove Alexander Hogmoen Astrand, Pal Rongved, Jan-Olof Winberg, Ingebrigt Sylte
Summary: Inhibition of bacterial virulence is a potential treatment option for bacterial infections. This study tested various compounds as inhibitors of bacterial virulence factors and human zinc metalloproteases, finding that some compounds showed strong inhibition of the metalloproteases MMP-14 and PLN.
Article
Engineering, Chemical
Quanxian Hua, Haojie Guo, Dasong Wang, Yukun Huang, Yijun Cao, Weijun Peng, Guixia Fan
Summary: Selective chelating precipitation-floatation method shows high efficiency and potential in the recovery of low-concentration cobalt ions from wastewater and the separation of cobalt and zinc.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Chemistry, Multidisciplinary
Shanyong Zhou, Datao Tu, Yan Liu, Wenwu You, Yunqin Zhang, Wei Zheng, Xueyuan Chen
Summary: This study proposes a facile and ultrasensitive detection method for tumor markers in saliva using luminescence-amplification strategy of lanthanide nanoprobes. By integrating dissolution enhanced luminescent bioassay strategy and miniaturized detection device, the unique lab-in-syringe assay enables the detection of tumor markers with high sensitivity and specificity, facilitating clinical diagnosis and home self-monitoring.
Article
Engineering, Chemical
A. Bringas, E. Bringas, R. Ibanez, Ma. -F. San-Roman
Summary: Chelating resins are used to recover valuable metals from spent acid streams containing heavy metals. In this study, a two-column system with BPA resins was used to selectively separate and recover nickel and copper. Mathematical models based on mass transfer were developed to describe the adsorption and desorption stages.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Andrea Cerrato, Chiara Cavaliere, Carmela Maria Montone, Susy Piovesana
Summary: The paper presents the preparation and characterization of a new HILIC material for the enrichment of N-linked glycopeptides. The material was prepared using specific monomer and cross-linker, and by fine-tuning the polymer properties, it displayed superior performance in terms of the number of enriched glycopeptides and selectivity. These results not only provide a new HILIC material for glycopeptide enrichment but also pave the way for the use of hydrogel materials in this field.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemical Research Methods
Sean Hamilton, Delaney Shea, Stuart Ibsen, Michael Brasino
Summary: Early detection is crucial for improving survival rates of cancer patients, but the 5-year survival rate for oral carcinoma has not seen much improvement. A new method involving the detection of lactate and the use of modified commensal bacteria as probes shows promise for noninvasive early detection of cancerous lesions in at-risk individuals.
Article
Chemistry, Multidisciplinary
Sijing Zhang, Jun Lin, Shuangli Chen, Huidong Xie, Yabing Qi
Summary: In this study, an apple pomace-based and 2,5-dimercapto-1,3,4-thiadiazole (DMTD)-immobilized bio-sorbent (DMTD-AP) was synthesized and characterized to enrich and recover Ag(I) from Ag (I)-Cu(II)-Pb(II)-Zn(II)-NI(II) effluent. The results showed that DMTD-AP had good selectivity for adsorbing Ag ions under certain conditions.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Chemistry, Multidisciplinary
Roger M. Pallares, Marimikel Charrier, Sara Tejedor-Sanz, Dong Li, Paul D. Ashby, Caroline M. Ajo-Franklin, Corie Y. Ralston, Rebecca J. Abergel
Summary: Rare-earth elements are essential for clean energy technologies, but their supply chain is at high risk of disruption. This study presents a synthetic biogenic material that mimics natural processes to extract lanthanides. The material demonstrates high affinity and selectivity for lanthanides, and the functionalized protein layers can be reused. These findings highlight the potential of biogenic materials in recovering critical elements from waste.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biotechnology & Applied Microbiology
Daniela Enriquez-Ochoa, David Melendez-Martinez, Jose Manuel Aguilar-Yanez, Cuauhtemoc Licona-Cassani, Karla Mayolo-Deloisa
Summary: Snake venoms are rich sources of proteins with potential biotechnological and pharmaceutical applications. Metalloproteases (MPs) and phospholipases A2 (PLA(2)) are the most abundant components. A cost-effective method based on aqueous two-phase systems (ATPS) was developed to recover MPs and PLA(2) from Crotalus molossus nigrescens venom, allowing for selective recovery of different protein subtypes under specific conditions.
BIORESOURCES AND BIOPROCESSING
(2021)
Article
Agricultural Engineering
Feixiang Zhang, Yong Qin, Changxun Zhao, Weixiang Wu
Summary: Soft magnetic ferrite is a potentially efficient additive for anaerobic digestion that can be recovered together with the microorganisms it carries. This study compared two typical soft magnetic ferrite materials and found that their addition increased methane production by 31% and 68% respectively. Both the ferrite materials and enriched microorganisms were effectively adsorbed post-digestion using a magnet. The study suggests that soft magnetic ferrite addition enhances biomethanization through various mechanisms such as enhanced syntrophic ac-etate oxidation and hydrogenotrophic methanogenesis.
BIORESOURCE TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Sumera Khizar, Amal A. Al-Dossary, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari
Summary: Viral diseases have a significant impact on global healthcare, social, and economic development, and nanotechnology holds promise for developing new diagnostic strategies. Modified magnetic nanoparticles can be used for extraction, purification, concentration, and specific virus recognition, playing a crucial role in combating viral outbreaks, especially COVID-19.
Article
Engineering, Environmental
M. Hermassi, M. Granados, C. Valderrama, C. Ayora, J. L. Cortina
Summary: A polymeric ion-exchange resin and a solvent impregnated resin were evaluated for the selective separation of Rare Earth Elements from various elements in acidic mine waters. The resins showed good separation factors through acidity control and the TP272 resin exhibited higher affinity towards Heavy REE. The integration of both resins could be used to recover REE as secondary resources for the clean energy technology industry.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Xiaowei Fang, Xingang Liu, Nianrong Sun, Chunhui Deng
Summary: A more efficient method to synthesize bimetallic mesoporous silica nanomaterials for phosphopeptides analysis was proposed in this study, which showed great sensitivity and selectivity in both standard digests and disease saliva samples, providing a candidate choice for future clinical examination.
Review
Chemistry, Analytical
Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Lobat Tayebi
Summary: In this study, novel magnetic nanofluids were prepared using deep eutectic solvents for the rapid microextraction of parabens from cosmetics samples. By optimizing various extraction parameters, high recoveries and excellent linearity were achieved for methylparaben, propylparaben, and butylparaben. The developed method exhibited efficiency, robustness, and reliability in comparison to other extraction methods.
Article
Biochemical Research Methods
Tania Lima, Joao Eduardo Rodrigues, Bruno Manadas, Rui Henrique, Margarida Fardilha, Rui Vitorino
Summary: This study reanalyzed a urine proteome dataset from prostate cancer patients and controls using a peptide-centric approach. Compared to the conventional protein-centric approach, the peptide analysis revealed more relevant information related to prostate cancer, highlighting the importance of peptide analysis in proteomics research.
JOURNAL OF PROTEOMICS
(2023)
Review
Chemistry, Analytical
Joao Pinto da Costa, Astrid Avellan, Catherine Mouneyrac, Armando Duarte, Teresa Rocha-Santos
Summary: Plastic additives are a group of substances used in the plastic industry for various purposes. They can assist in molding plastics, improve performance, and reduce costs. However, these additives, along with nonpolymerized monomers, can be more hazardous and pose risks to the environment and human health. This article provides an overview of the mechanistic uptake/release of these compounds, discusses the potential ecological consequences, and explores analytical methodologies for their determination. It also highlights the limitations of current literature and presents future research prospects.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Diogo Marinheiro, Fatima Martel, Barbara J. M. L. Ferreira, Ana L. L. Daniel-da-Silva
Summary: Diabetes mellitus, a global epidemic, is associated with serious health threats including cardiovascular diseases. Current treatments have limitations, driving the development of new effective formulations. Silica-based nanocarriers show potential for treating diabetes and regulating blood glucose concentration due to their tunable characteristics. This review discusses topics such as oral insulin administration, glucose-responsive devices, and innovative drug delivery routes.
BIOENGINEERING-BASEL
(2023)
Article
Materials Science, Ceramics
Sofia F. Soares, Ana L. Daniel-da-Silva, Tito Trindade
Summary: This study demonstrates the successful modification of hybrid siliceous materials with transition metals (TM = Co2+, Ni2+, Cu2+, Zn2+) using a sol-gel method with the polysaccharide kappa-carrageenan as a precursor. Structural analysis and characterization studies were conducted, and the effects of the TM ions on the properties of the hybrids were assessed. The results show that the modification with TM induces changes in the morphological, optical, and thermal properties of the hybrids compared to the unmodified analogs, indicating the practical applicability of the sol-gel method for modifying the properties of host particles.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Catarina Cunha, Diogo Marinheiro, Barbara J. M. L. Ferreira, Helena Oliveira, Ana L. Daniel-da-Silva
Summary: Incidence of melanoma, a type of skin cancer, is increasing worldwide. Morin, a bioflavonoid, shows potential for cancer treatment including melanoma, but its therapeutic applications are limited due to low solubility and bioavailability. This study investigates the use of morin hydrate encapsulated in mesoporous silica nanoparticles to enhance bioavailability and antitumor effects in melanoma cells.
Article
Oncology
Rui Vitorino, Antonio S. Barros, Sofia Guedes, Douglas C. Caixeta, Robinson Sabino-Silva
Summary: NIR spectroscopy is a valuable tool for cancer diagnosis and treatment. It reveals inherent differences between tumor and normal tissue and provides insights into cancer patterns and physiology. The integration of NIR spectroscopy with advanced algorithms makes it a cutting-edge technology with great potential in medical applications.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemical Research Methods
Maria J. Cardoso Ferreira, Tania Soares Martins, Steven R. Alves, Ilka Martins Rosa, Jonathan Vogelgsang, Niels Hansen, Jens Wiltfang, Odete A. B. da Cruz e Silva, Rui Vitorino, Ana Gabriela Henriques
Summary: Aging is the main risk factor for age-related neurodegenerative diseases, such as Alzheimer's disease (AD), which is characterized by the presence of senile plaques (SPs) and neurofibrillary tangles (NFTs). This study conducted a literature review to identify the proteomes of SPs and NFTs, followed by a bioinformatic analysis and validation of potential biomarkers.
Article
Green & Sustainable Science & Technology
Veronica Godoy, Joana Correia Prata, Antonio Perez, Joao Pinto da Costa, Teresa Rocha-Santos, Armando C. Duarte
Summary: The main objective of this study was to estimate the microplastic pollution on Costa Nova sandy beach in Portugal using longitudinal and cross-sectional transects. The results showed low variability in data, with median concentrations ranging from 142 to 356 p/kg d.w. in cross-sectional transects, and from 211 to 270 p/kg d.w. in longitudinal transects. Microspheres were the predominant morphology, accounting for over 90% of all samples, and the most abundant microplastics were <200 μm in size. Despite moderate-low tourist activity, microplastic contamination was higher in Costa Nova compared to other Portuguese beaches, possibly due to nearby port activities and ocean currents. However, this study highlights the disparity in data caused by different methodologies used in analyzing similar areas.
Editorial Material
Biochemistry & Molecular Biology
Rui Vitorino
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giulia Guadalupi, Cristina Contini, Federica Iavarone, Massimo Castagnola, Irene Messana, Gavino Faa, Simona Onali, Luchino Chessa, Rui Vitorino, Francisco Amado, Giacomo Diaz, Barbara Manconi, Tiziana Cabras, Alessandra Olianas
Summary: This study investigated the quantitative variations on the salivary proteome in autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) patients. Several differentially expressed proteins related to the diseases were identified. Machine learning analysis confirmed the potential of the salivary proteome to discriminate AIH and PBC patients. The functional enrichment analysis highlighted the involvement of the immune system, liver fibrosis process, and antimicrobial activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Rita Ferreira, Francisco Amado, Rui Vitorino
Summary: Bioinformatics plays a critical role in advancing peptidomics by providing powerful tools for accelerating peptide discovery, understanding their functions, and gaining insights into complex molecular interactions.
Article
Medicine, Research & Experimental
Catarina Alves-Vale, Ana Maria Capela, Carlota Tavares-Marcos, Beatriz Domingues-Silva, Bruno Pereira, Francisco Santos, Carla Pereira Gomes, Guadalupe Espadas, Rui Vitorino, Eduard Sabido, Paula Borralho, Sandrina Nobrega-Pereira, Bruno Bernardes de Jesuse
Summary: The recently discovered lncRNA NORAD is induced after DNA damage in a p53-dependent manner and it plays a critical role in maintaining genomic stability. NORAD is upregulated in several types of cancer, including breast cancer, and high NORAD expression levels are associated with poor prognosis. In this study, it was found that downregulation of NORAD sensitizes triple-negative breast cancer cells to chemotherapy.
MOLECULAR THERAPY NUCLEIC ACIDS
(2023)
Article
Instruments & Instrumentation
Maria Mendes, Francisco Branco, Rui Vitorino, Joao Sousa, Alberto Pais, Carla Vitorino
Summary: This study proposes a two-pronged approach for tackling glioblastoma (GB) using drug repurposing with celecoxib (CXB) and a nanoformulation with ultra-small nanostructured lipid carriers (usNLCs). The results demonstrate that by enhancing the design and construction of the nanoformulation, the solubility and loading properties of CXB can be improved, enabling controlled drug release and high cytotoxicity. This nanoformulation holds promise for improving the treatment of GB.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Analytical
Maria Antonio, Tania Lima, Rita Ferreira, Margarida Fardilha, Jose Mesquita Bastos, Rui Vitorino, Ana. L. Daniel-da-Silva
Summary: In this study, a colorimetric and low-cost approach for detecting and quantifying Gal-3 using gold nanoparticles bioconjugated with Gal-3 antibody was developed. The method showed a linear response of the absorbance ratio to Gal-3 concentration, accompanied by a change in color intensity. It provided faster results and was more cost-effective compared to conventional detection techniques.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Multidisciplinary
Sofia F. Soares, Joao Nogueira, Tito Trindade, Ana L. Daniel-da-Silva
Summary: Efficient removal of the antibiotic ciprofloxacin from aqueous samples using magnetic nanosorbents prepared with sulfated polysaccharides was described. The nanosorbents exhibited high adsorption capacity and could be reused.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)