Article
Radiology, Nuclear Medicine & Medical Imaging
Giovanni Donato Aquaro, Marco Di Paolo, Benedetta Guidi, Khatia Ghabisonia, Angela Pucci, Giacomo Aringheri, Nikoloz Gorgodze, Musetti Veronica, Enrica Chiti, Silvia Burchielli, Emanuela Turillazzi, Michele Emdin, Davide Caramella, Fabio A. Recchia
Summary: Post-mortem cardiac magnetic resonance (PM-CMR) is effective in detecting early signs of myocardial damage induced by ischemia within 90 minutes, based on conventional pulse sequences complemented by quantitative mapping techniques.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Andrew E. Radbill, Lucy Y. Lei, Sachin Y. Paranjape, Daniel J. Blackwell, Robert L. Abraham, Derek S. Chew, Satish R. Raj, Bjorn C. Knollmann
Summary: This study aimed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Findings show that rapid pacing trains triggered ventricular ectopy in hypertrophic cardiomyopathy patients, but not controls. However, there were no significant differences observed in surrogate measures for cardiac contractility, suggesting that altered length-dependent myofilament activation may not have significant clinical implications in these patients.
Article
Cardiac & Cardiovascular Systems
Yun-Jiu Cheng, Yu-He Jia, Feng-Juan Yao, Wei-Yi Mei, Yuan-Sheng Zhai, Ming Zhang, Su-Hua Wu
Summary: This study demonstrates that incident silent myocardial infarction (SMI) is independently associated with an increased risk of sudden cardiac death (SCD) in the general population, particularly in white individuals, men, and younger age groups. Additional research is needed to investigate screening for SMI and the role of standard post-myocardial infarction therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Curt J. Daniels, Saurabh Rajpal, Joel T. Greenshields, Geoffrey L. Rosenthal, Eugene H. Chung, Michael Terrin, Jean Jeudy, Scott E. Mattson, Ian H. Law, James Borchers, Richard Kovacs, Jeffrey Kovan, Sami F. Rifat, Jennifer Albrecht, Ana I. Bento, Lonnie Albers, David Bernhardt, Carly Day, Suzanne Hecht, Andrew Hipskind, Jeffrey Mjaanes, David Olson, Yvette L. Rooks, Emily C. Somers, Matthew S. Tong, Jeffrey Wisinski, Jason Womack, Carrie Esopenko, Christopher J. Kratochvil, Lawrence D. Rink
Summary: In this study of 1597 competitive athletes in the US who underwent CMR screening after COVID-19 infection, 37 athletes (2.3%) were diagnosed with clinical and subclinical myocarditis. There was variability in prevalence across universities, and testing protocols were closely associated with the detection of myocarditis. The unique CMR imaging data highlight the need for standardized timing and interpretation of cardiac testing for safe return to play in athletes.
Review
Chemistry, Physical
Xu Wang, Jun Pu
Summary: Cardiac magnetic resonance (CMR) imaging technology is considered the gold standard for evaluating myocardial function and viability in acute myocardial infarction (AMI). Various CMR techniques can specifically display and evaluate the pathophysiological changes in each stage of AMI. This article reviews the recent advances of CMR technology in AMI and prospects its future development directions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alberto Cipriani, Giulia Mattesi, Riccardo Bariani, Annagrazia Cecere, Nicolo Martini, Laura De Michieli, Stefano Da Pozzo, Simone Corradin, Giorgio De Conti, Alessandro Zorzi, Raffaella Motta, Manuel De Lazzari, Barbara Bauce, Sabino Iliceto, Cristina Basso, Domenico Corrado, Martina Perazzolo Marra
Summary: Arrhythmogenic cardiomyopathy (ACM) is a genetically determined heart muscle disease characterized by fibro-fatty myocardial replacement, clinically associated with malignant ventricular arrhythmias and sudden cardiac death. Cardiac magnetic resonance (CMR) has emerged as the key imaging technique for the diagnosis of ACM, providing detailed evaluation of both right ventricular (RV) and left ventricular (LV) morphology, function, and tissue characteristics, as well as supplemental value for disease variants.
EUROPEAN RADIOLOGY
(2023)
Article
Biology
Brett C. Baggett, Kevin R. Murphy, Elif Sengun, Eric Mi, Yueming Cao, Nilufer N. Turan, Yichun Lu, Lorraine Schofield, Tae Yun Kim, Anatoli Y. Kabakov, Peter Bronk, Zhilin Qu, Patrizia Camelliti, Patrycja Dubielecka, Dmitry Terentyev, Federica del Monte, Bum-Rak Choi, John Sedivy, Gideon Koren
Summary: Progressive tissue remodeling after myocardial infarction promotes cardiac arrhythmias. Little is known about pro-arrhythmic changes in aged animals. In this study, aged rabbits exhibited increased peri-procedural mortality and arrhythmogenic electrophysiological remodeling at the infarct border zone (IBZ) compared to young rabbits. Computational modeling showed that senescent myofibroblast-cardiomyocyte coupling prolongs action potential duration (APD) and facilitates conduction block permissive of arrhythmias. The findings suggest that therapeutic interventions targeting senescent cells may mitigate arrhythmias post-MI with age.
Article
Cardiac & Cardiovascular Systems
S. Neil Holby, Tadarro Lee Richardson Jr, J. Lukas Laws, Thomas A. McLaren, Jonathan H. Soslow, Michael T. Baker, Jeffrey M. Dendy, Daniel E. Clark, Sean G. Hughes
Summary: Infection with SARS-CoV-2, the virus that causes COVID, can lead to various cardiovascular complications. Cardiac imaging has become crucial in differentiating pulmonary and cardiovascular complications due to the non-specific symptoms and laboratory findings of COVID patients. This review summarizes the existing literature and major societal guidelines to provide an overview of the indications and utility of different cardiac imaging modalities for diagnosing cardiovascular complications of COVID.
CIRCULATION RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Domenico Corrado, Alessandro Zorzi, Alberto Cipriani, Barbara Bauce, Riccardo Bariani, Giorgia Beffagna, Manuel De Lazzari, Federico Migliore, Kalliopi Pilichou, Alessandra Rampazzo, Ilaria Rigato, Stefania Rizzo, Gaetano Thiene, Martina Perazzolo Marra, Cristina Basso
Summary: Criteria for diagnosis of arrhythmogenic cardiomyopathy (ACM) have evolved from the original proposals in 1994 and revisions in 2010, to the modern 2020 International criteria (Padua criteria) which heavily rely on cardiac magnetic resonance for improved diagnosis of left ventricular phenotypic features. These new criteria also include assessments for left ventricular ECG abnormalities and arrhythmias.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giovanni Donato Aquaro, Carmelo De Gori, Giulia Grilli, Roberto Licordari, Andrea Barison, Giancarlo Todiere, Umberto Ianni, Matteo Parollo, Crysanthos Grigoratos, Luca Restivo, Antonio De Luca, Lorenzo Faggioni, Dania Cioni, Gianfranco Sinagra, Gianluca Di Bella, Emanuele Neri
Summary: The prognostic role of left ventricular papillary muscle abnormalities in patients with preserved LV systolic ejection fraction is unclear. This study aimed to evaluate the predictive role of LV papillary muscle abnormalities by CMR in patients with ventricular arrhythmias and preserved LVEF. The results showed that Dark-Paps is a novel prognostic marker in patients with ventricular arrhythmias and preserved ejection fraction.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Quanmei Ma, Yue Ma, Xiaonan Wang, Shanshan Li, Tongtong Yu, Weili Duan, Jiake Wu, Zongyu Wen, Yundi Jiao, Zhaoqing Sun, Yang Hou
Summary: This study established and validated a non-contrast T1 map-based radiomic nomogram for predicting major adverse cardiac events (MACEs) in acute STEMI patients undergoing PCI. The radiomic signature showed good prognostic ability in both training and test sets, while the nomogram combining radiomic scores and cardiac troponin I demonstrated good discrimination ability for predicting MACEs.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lorraine Sazgary, Christian Puelacher, Giovanna Lurati Buse, Noemi Glarner, Andreas Lampart, Daniel Bolliger, Luzius Steiner, Lorenz Guerke, Thomas Wolff, Edin Mujagic, Stefan Schaeren, Didier Lardinois, Jacqueline Espinola, Christoph Kindler, Angelika Hammerer-Lercher, Ivo Strebel, Karin Wildi, Reka Hidvegi, Johanna Gueckel, Christina Hollenstein, Tobias Breidthardt, Katharina Rentsch, Andreas Buser, Danielle M. Gualandro, Christian Mueller
Summary: MACE incidence after non-cardiac surgery is 15.2% at 30 days and 20.6% at 365 days for high-risk patients, with the risk remaining elevated for about 5 months post-surgery.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David M. Raffel, Thomas C. Crawford, Yong-Woon Jung, Robert A. Koeppe, Guie Gu, Jill Rothley, Kirk A. Frey
Summary: The study evaluated the performance of F-18-4F-MHPG and F-18-3F-PHPG in cardiomyopathy patients, demonstrating their robustness in quantifying regional cardiac sympathetic nerve density. Both tracers provided comparable metrics of nerve density and left ventricular denervation, with F-18-4F-MHPG showing advantages of faster liver clearance and more consistent plasma metabolism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Xuewen Wang, Yongsheng Qian, Yajun Yao, Youcheng Wang, Youjing Zhang, Shujuan Zhang, Qingyan Zhao
Summary: This study demonstrates that MNS can increase ventricular fibrillation threshold in a canine model with MI and the effect may be associated with the cholinergic anti-inflammatory pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yue Gao, Hua-yan Xu, Ying-kun Guo, Xiao-ling Wen, Rui Shi, Yuan Li, Zhi-gang Yang
Summary: The study found that myocardial scarring size in T2DM patients after MI is negatively correlated with LV global PS and PSSR, particularly in the circumferential direction. Different MI regions have different effects on the reduction of LV deformation, and relevant clinical evaluations should be strengthened.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fabian Muehlberg, Markus Kornfeld, Leonora Zange, Saeed Ghani, Annette Reichardt, Peter Reichardt, Jeanette Schulz-Menger
Summary: This study aims to assess the subclinical changes in functional and morphologic myocardial MR parameters early in the course of high-dose anthracycline treatment. The results suggest that an early increase in myocardial T2 times 48 hours after the first anthracycline treatment may predict the subsequent development of anthracycline-induced cardiomyopathy. Additionally, a decrease in native T1 times was observed regardless of the development of cardiomyopathy in high-dose anthracycline therapy.
Review
Cardiac & Cardiovascular Systems
Lilia M. M. Sierra-Galan, Niti R. R. Aggarwal, Jadranka Stojanovska, Subha V. V. Raman, Yuchi Han, Vanessa M. M. Ferreira, Katharine Thomas, Nicole Seiberlich, Purvi Parwani, Chiara Bucciarelli-Ducci, Lauren A. A. Baldassarre, Sophie Mavrogeni, Karen Ordovas, Jeanette Schulz-Menger, W. Patricia Bandettini
Summary: Women's participation in medicine, particularly in cardiovascular imaging and cardiovascular MRI (CMR), has gradually increased over the past few decades. More and more women have joined the cardiovascular imaging community to contribute their expertise. This collaborative work summarizes the challenges women in cardiovascular imaging have overcome, the positive interventions implemented to support women in CMR, and the remaining obstacles, with a specific focus on women physicians.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kirsten Miriam Kerkering, Jeanette Schulz-Menger, Tobias Schaeffter, Christoph Kolbitsch
Summary: In this study, a method was proposed to achieve T1 mapping of the myocardium within 2.3 s by utilizing both cardiac motion correction and model-based T1 reconstruction. The accuracy of cardiac motion estimation and T1 estimation was demonstrated through numerical simulations, phantom experiments, and in vivo scans in healthy volunteers. The proposed approach provided faster T1 mapping with improved precision.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bobak Heydari, Yin Ge, Panagiotis Antiochos, Sabeeh Islam, Kevin Steel, Scott Bingham, Shuaib Abdullah, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Sujata M. Shanbhag, Afshin Farzaneh-Far, John F. Heitner, Chetan Shenoy, Steve W. Leung, Jorge A. Gonzalez, Subha V. Raman, Victor A. Ferrari, Dipan J. Shah, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
Summary: This study investigated the impact of sex on the prognostic utility, invasive revascularization, and costs of stress perfusion CMR for suspected CVD. The findings showed that women with normal CMR had a lower rate of cardiovascular events compared to men, while women with abnormal CMR had a higher risk of cardiovascular events. Additionally, women had lower rates of invasive coronary angiography and associated costs following CMR.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Leili Riazy, Sascha Daeuber, Steffen Lange, Darian Steven Viezzer, Steffen Ott, Stephanie Wiesemann, Edyta Blaszczyk, Fabian Muehlberg, Leonora Zange, Jeanette Schulz-Menger
Summary: Standardization is crucial for reproducible results in cardiac magnetic resonance (CMR) examinations. Therefore, quality control, such as statistical detection of long-term drifts, is of great importance. In this study, quantitative parameters of the left ventricle were analyzed over time using moving averages, and potential causes for quality relevant changes were investigated. The results showed 50 potential quality relevant changes in SV, EDV, and LVM, with no identified causal factors such as staff changes, scanner relocation, or software changes. Statistical quality assurance systems based on moving average control charts could contribute to the reliability of quantitative CMR.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Stephanie Wiesemann, Ralf Felix Trauzeddel, Ahmed Musa, Richard Hickstein, Thomas Mayr, Florian von Knobelsdorff-Brenkenhoff, Emilie Bollache, Michael Markl, Jeanette Schulz-Menger
Summary: Non-invasive assessment of aortic hemodynamics using 4D flow MRI provides new information on blood flow patterns and wall shear stress. This study investigates changes in aortic hemodynamics in patients with aortic valve stenosis and/or bicuspid aortic valves after aortic valve replacement.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian Fenski, Leo Dyke Krueger, Jeanette Schulz-Menger
Summary: Cardiovascular magnetic resonance (CMR) is not only valuable for diagnosis, but also increasingly important for therapeutic decision making and prevention of sudden cardiac death. This review discusses the role of CMR in ventricular arrhythmias, focusing on dilated, hypertrophic, and arrhythmogenic cardiomyopathy, as well as post-myocardial infarction patients in the chronic stage. It also presents relevant MRI techniques, protocols, expected study results, and knowledge gaps.
AKTUELLE KARDIOLOGIE
(2023)
Article
Computer Science, Interdisciplinary Applications
Thomas Hadler, Clemens Ammann, Jens Wetzl, Darian Viezzer, Jan Groeschel, Maximilian Fenski, Endri Abazi, Steffen Lange, Anja Hennemuth, Jeanette Schulz-Menger
Summary: This study developed software called Lazy Luna for the quantitative evaluation of cardiovascular magnetic resonance imaging. The software allows for comparing annotated images from artificial intelligence and clinicians, ensuring accurate metric calculations. It provides a graphical user interface for non-programmers and enables the tracing of differences in segmentation results among readers to identify the origins of these differences. The software can be extended to new application cases.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Blaszczyk, S. Hellwig, H. Saad, R. Ganeshan, H. Stengl, C. H. Nolte, J. B. Fiebach, M. Endres, J. Kuhnt, J. Groeschel, J. Schulz-Menger, J. F. Scheitz
Summary: More than one-third of patients with acute ischemic stroke show evidence of focal myocardial fibrosis on CMR, accompanied by diffuse myocardial changes and reduced myocardial deformation. Further studies are needed to establish the impact of these findings on long-term prognosis after acute ischemic stroke.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Rolf, Ingo Eitel, Mirja Neizel-Wittke, Ulf K. Radunski, Peter Bernhardt, Florian von Knobelsdorff, Florian Andre, Eike Nagel, Jeanette Schulz-Menger, Sebastian Kelle
Summary: The aim of this curriculum is to provide further education for cardiologists in the field of cardiac magnetic resonance imaging (C-MRI) in order to achieve expert certification. It covers the necessary knowledge and skills for cardiologists to accurately assess, perform, and interpret C-MRI examinations in a wide range of cardiovascular diseases. The curriculum also includes the management of C-MRI laboratories and the ability to conduct scientific C-MRI examinations at a high level. The certification process follows the recommendations of reputable European societies for harmonizing education and facilitating exchange in Europe.
Review
Cardiac & Cardiovascular Systems
Florian von Knobelsdorff-Brenkenhoff, Jeanette Schulz-Menger
Summary: This study summarizes the current evidence and role of cardiovascular magnetic resonance (CMR) in the guidelines of the European Society of Cardiology (ESC). It found that 70.4% of the guidelines contain relevant text passages regarding CMR, with 92 specific recommendations regarding its use. Most of the recommendations have level C evidence and cover various aspects of CMR applications.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Bobby Heydari, Yin Ge, Panagiotis Antiochos, Sabeeh Islam, Kevin E. Steel, Scott E. Bingham, Shuaib Abdullah, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Sujata Madhukar Shanbhag, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steven Leung, Jorge A. Gonzalez, Subha V. Raman, Victor A. Ferrari, Dipan J. Shah, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sabeeh Islam, Bobby Heydari, Yin Ge, Panagiotis Antiochos, Kevin E. Steel, Scott E. Bingham, Shuaib Abdullah, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Sujata Madhukar Shanbhag, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steve Leung, Jorge A. Gonzalez, Subha V. Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Orlando P. Simonetti, Matthias Stuber, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Saadia Qazi, Yin Ge, Krishna Patel, Panagiotis Antiochos, Sabeeh Islam, Ryan B. Longmore, Bobby Heydari, Scott E. Bingham, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Sujata Madhukar Shanbhag, Amit R. Patel, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steve Leung, Jorge A. Gonzalez, Dipan J. Shah, Subha V. Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Vanessa M. Ferreira, Sven Plein, Timothy C. Wong, Qian Tao, Zahra Raisi-Estabragh, Supriya S. Jain, Yuchi Han, Vineeta Ojha, David A. Bluemke, Kate Hanneman, Jonathan Weinsaft, Mahesh K. Vidula, Ntobeko A. B. Ntusi, Jeanette Schulz-Menger, Jiwon Kim
Summary: Coronavirus disease 2019 (COVID-19) is a global pandemic that has affected nearly 600 million people worldwide. While primarily a respiratory illness, COVID-19 can also cause cardiac injury. Cardiovascular magnetic resonance (CMR) imaging can provide insights into the pattern and degree of cardiac injury. The reported prevalence of myocardial involvement among COVID-19 patients evaluated with CMR ranges from 26% to 60%. Standardized methodologies in imaging and reporting would likely improve consistency between studies. The Society for Cardiovascular Magnetic Resonance (SCMR) provides recommendations for standardized CMR imaging and reporting in COVID-19 patients.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)