Article
Engineering, Biomedical
Dong Qiu, Mohammed Barakat, Brenna Hopkins, Saba Ravaghi, Ali N. Azadani
Summary: Bicuspid aortic valve stenosis is a common congenital cardiac anomaly leading to aortic stenosis. Transcatheter aortic valve replacement (TAVR) has shown positive outcomes in low-risk patients, but the asymmetrical anatomy of bicuspid valves can hinder the complete expansion of TAVs, potentially leading to increased leaflet stress and impaired leaflet kinematics. Studies comparing different TAV devices in bicuspid valves revealed that elliptical and incomplete stent deployment may have negative impacts on valve durability and blood flow dynamics.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Review
Cardiac & Cardiovascular Systems
Deborah J. Henderson, Lorraine Eley, Jasmin E. Turner, Bill Chaudhry
Summary: The development of arterial valves is poorly understood in both humans and mice. This review summarizes what is known about the development of human arterial valve leaflets and compares it to mice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sameer A. Hirji, Zachary Wegermann, Sreekanth Vemulapalli, Paige Newell, Maria Grau-Sepulveda, Sean O'Brien, Vinod H. Thourani, Vinay Badhwar, Tsuyoshi Kaneko
Summary: This study analyzes the 5-year outcomes of isolated surgical aortic valve replacement (SAVR) in patients with bicuspid and tricuspid aortic valve stenosis. The results show that bicuspid patients have significantly lower 5-year mortality rates compared to tricuspid patients, especially in low-risk patients.
ANNALS OF THORACIC SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Jiaxing Jason Qin, Peyman Obeidy, Mustafa Gok, Alireza Gholipour, Stuart M. M. Grieve
Summary: The current intervention guidelines for BAV-associated AAo dilatation are not accurate predictors of clinical outcomes. This review examines the relationship between WSS and aortopathy in the BAV population, aiming to identify better biomarkers for risk stratification. The review includes 26 studies that demonstrate the elevated WSS magnitude and circumferential WSS in BAV patients, highlighting the potential of WSS as a valid biomarker for BAV aortopathy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gilles Soulat, Michael B. Scott, Ashitha Pathrose, Kelly Jarvis, Haben Berhane, Bradley Allen, Ryan Avery, Alejandro Roldan Alsate, Cynthia K. Rigsby, Michael Markl
Summary: This study investigated the relationships between hemodynamic parameters and longitudinal changes in aortic dimensions in patients with bicuspid aortic valve (BAV) and repaired coarctation using four-dimensional (4D) flow magnetic resonance imaging (MRI). The results showed that peak velocity was associated with the progression of narrowing in the repaired coarctation.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Natalie Glaser, Veronica Jackson, Per Eriksson, Ulrik Sartipy, Anders Franco-Cereceda
Summary: The study aimed to analyze long-term survival in patients with Bicuspid Aortic Valve (BAV) who underwent aortic valve surgery. Results showed that the survival of BAV patients following surgery was excellent and similar to the general population, with slightly lower survival rates for women compared to men. These findings suggest that the timing of surgery according to current guidelines is appropriate and provide valuable information about the natural history of BAV in patients post-aortic valve surgery.
Article
Cardiac & Cardiovascular Systems
Jose M. Siurana, Anna Sabate-Rotes, Ariadna Ayerza, Lorenzo Jimenez, Marc Figueras-Coll, Maria Aranzazu Gonzalez
Summary: This study aimed to find the best reference tool to define dilation of the aortic root and the ascending aorta in BAV adolescents with an adult body surface area (BSA). The results indicate that in the ascending aorta, it is advisable to switch to BSA-IV when children are older than 10 years old and have a BSA >= 1.5 m2.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Physiology
Guillaume Goudot, Charles Cheng, Alexis F. Guedon, Tristan Mirault, Olivier Pedreira, Alexandre Dahan, Louise Z. Wang, Mathieu Pernot, Emmanuel Messas
Summary: This study developed an automated method for aortic data acquisition using ultrafast ultrasound imaging (UUI) to assess the aortic maximal rate of systolic distention (MRSD). The results showed that UUI technology can accurately track the aortic diameter and calculate the MRSD value, which is important for evaluating aortic diseases associated with bicuspid aortic valve.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bo Hwa Choi, Sung Min Ko, Je Kyoun Shin, Hyun Keun Chee, Jun Seok Kim
Summary: The study found that the morphological characteristics of BAV did not determine aortic dilatation, but age, sex, and severity of aortic stenosis were predictors of bicuspid aortopathy. This suggests that treatment planning for BAV patients should focus on age, sex, and aortic stenosis severity rather than valve morphology.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juan Garrido-Oliver, Jordina Aviles, Marcos Mejia Cordova, Lydia Dux-Santoy, Aroa Ruiz-Munoz, Gisela Teixido-Tura, Gonzalo D. Maso Talou, Xabier Morales Ferez, Guillermo Jimenez, Arturo Evangelista, Ignacio Ferreira-Gonzalez, Jose Rodriguez-Palomares, Oscar Camara, Andrea Guala
Summary: This study developed a fully automatic machine learning-based pipeline for analyzing complex aortic flow dynamics from 4D flow CMR. The results showed that automatic aortic segmentation, landmark detection, and flow assessment were consistent with manual operations, indicating the feasibility of fully automatic analysis and its potential for enhancing the clinical use of 4D flow CMR.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jooae Choe, Hyun Jung Koo, Joon-Won Kang, Joon Bum Kim, Hee Jun Kang, Dong Hyun Yang
Summary: This study confirmed a significant correlation between bicuspid aortic valve annulus diameter measured on CT and surgical aortic valve size. The difference between CT-derived diameter and surgical AVR size is influenced by operator factors and types of prostheses rather than the bicuspid valve itself.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Breandan B. B. Yeats, Krishna Sivakumar, Milad Samaee, Venkateshwar Polsani, Pradeep K. K. Yadav, Vinod H. H. Thourani, Stephanie Sellers, Janarthanan Sathananthan, Lakshmi P. P. Dasi
Summary: This study investigates the impact of calcium fracture and balloon over expansion on stent deformation in balloon-expandable transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve disease. The results suggest that calcium fracture has minimal effects on expansion and circularity, while balloon over expansion brings the stent expansion closer to nominal values.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Suyog A. Mokashi, Brad F. Rosinski, Milind Y. Desai, Brian P. Griffin, Donald F. Hammer, Vidyasagar Kalahasti, Douglas R. Johnston, Jeevanantham Rajeswaran, Eric E. Roselli, Eugene H. Blackstone, Lars G. Svensson
Summary: The study compared the intermediate-term outcomes of aortic root replacement with valve-sparing reimplantation of bicuspid and tricuspid aortic valves, showing no significant differences in postoperative mortality, morbidity, aortic valve reoperation, and survival between the two groups. However, bicuspid aortic valve patients had higher mean gradients and more severe aortic regurgitation, indicating the need for continued long-term surveillance.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Charles Cheng, Yohann Bohbot, Hector Michelena, Dan Rusinaru, Floriane Fay, Frederic Elmkies, Maurice Enriquez Sarano, Christophe Tribouilloy
Summary: This study describes the clinical history of patients with BAV across different age groups and evaluates the long-term outcomes of patients referred for surgery. The results showed high survival rates in both the surveillance and surgical groups, with low incidences of complications.
MAYO CLINIC PROCEEDINGS
(2021)
