Review
Medicine, General & Internal
Francesco Pelliccia, Franco Cecchi, Iacopo Olivotto, Paolo G. Camici
Summary: Myocardial ischemia is a pathophysiological feature of hypertrophic cardiomyopathy that affects heart function and sudden cardiac death. Coronary microvascular dysfunction is the main factor contributing to myocardial ischemia, and thus a multimodality approach is necessary for the detailed assessment of microvascular dysfunction and ischemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Emanuele Monda, Giuseppe Palmiero, Michele Lioncino, Marta Rubino, Annapaola Cirillo, Adelaide Fusco, Martina Caiazza, Federica Verrillo, Gaetano Diana, Alfredo Mauriello, Michele Iavarone, Maria Angela Losi, Maria Luisa De Rimini, Santo Dellegrottaglie, Antonello D'Andrea, Eduardo Bossone, Giuseppe Pacileo, Giuseppe Limongelli
Summary: Multimodality imaging plays a crucial role in the diagnosis and management of patients with HCM, and can uncover the specific causes of HCM for targeted treatments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Maja Schlittler, Peter P. Pramstaller, Alessandra Rossini, Marzia De Bortoli
Summary: Hypertrophic cardiomyopathy is the most common inherited heart disease and a leading cause of sudden cardiac death in young people. Mutations in genes that encode structural proteins of the heart can cause hypertrophic cardiomyopathy, leading to myocardial fibrosis and impaired cardiac function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Min-Chi Ku, Frank Kober, Yi-Ching Lai, Andreas Pohlmann, Fatimunnisa Qadri, Michael Bader, Lucie Carrier, Thoralf Niendorf
Summary: The study demonstrated impaired resting myocardial perfusion and microvascular dysfunction in a mouse model of HCM, characterized by increased left ventricular wall thickness, reduced myocardial blood flow, lower vessel densities, and higher levels of myocardial fibrosis and perivascular fibrosis.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Acoustics
Xin Hu, Yuwei Bao, Ying Zhu, Kangchao Zheng, Jun Zhang, Wei Zhou, Youbin Deng, Yani Liu
Summary: This study aimed to investigate the predictive value of multiple strain parameters for myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM) using speckle tracking automated functional imaging (AFI). The results showed that GLS could predict significant myocardial fibrosis.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Claire E. Raphael, Frances Mitchell, Gajen Sunthar Kanaganayagam, Alphonsus C. Liew, Elisa Di Pietro, Miguel Silva Vieira, Lina Kanapeckaite, Simon Newsome, John Gregson, Ruth Owen, Li-Yueh Hsu, Vassilis Vassiliou, Robert Cooper, Aamir Ali MRCP, Tevfik F. Ismail, Brandon Wong, Kristi Sun, Peter Gatehouse, David Firmin, Stuart Cook, Michael Frenneaux, Andrew Arai, Rory O'Hanlon, Dudley J. Pennell, Sanjay K. Prasad
Summary: HF incidence is low in HCM patients undergoing CMR. Myocardial fibrosis and LVESVI are strong predictors of future HF, while CMR visual assessment of myocardial perfusion does not predict outcomes.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Health Care Sciences & Services
Aleksandra Karabinowska-Malocha, Ewa Dziewiecka, Pawel Banys, Malgorzata Urbanczyk-Zawadzka, Maciej Krupinski, Malgorzata Mielnik, Jacek Lach, Aleksandra Budkiewicz, Piotr Podolec, Lukasz Zydzik, Sylwia Wisniowska-Smialek, Katarzyna Holcman, Magdalena Kostkiewicz, Pawel Rubis
Summary: This study aimed to evaluate the relationship between interstitial fibrosis on cardiac magnetic resonance (CMR) and non-sustained ventricular tachycardia (nsVT) in hypertrophic cardiomyopathy (HCM). The study found that the presence of late gadolinium enhancement (LGE) alone is not enough to determine the occurrence of nsVT in HCM patients, but rather the actual extent of LGE is important, while the role of interstitial fibrosis remains unclear.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Ji-won Hwang, Sang-Chol Lee, Darae Kim, Jihoon Kim, Eun Kyoung Kim, Sung-A Chang, Sung-Ji Park, Sung Mok Kim, Yeon Hyeon Choe, Joong Hyun Ahn, Seung Woo Park
Summary: The present study aimed to identify factors that may affect exercise capacity in patients with hypertrophic cardiomyopathy (HCM). The results showed that age, female sex, increased NT-proBNP level, and E/e' ratio on echocardiography were significantly associated with decreased exercise capacity. Monitoring hemodynamic changes and increased filling pressure on echocardiography is important for improved outcomes in this population.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Hyemoon Chung, Eui-Young Choi
Summary: This article reviews the role of multimodal imaging in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF), emphasizing the importance of evaluating the morphology and physiology of the atrium and ventricle for treatment and prognosis determination.
Article
Cardiac & Cardiovascular Systems
George Joy, Christopher I. Kelly, Matthew Webber, Iain Pierce, Irvin Teh, Louise Mcgrath, Paula Velazquez, Rebecca K. Hughes, Huafrin Kotwal, Arka Das, Fiona Chan, Athanasios Bakalakos, Massimiliano Lorenzini, Konstantinos Savvatis, Saidi A. Mohiddin, Peter W. Macfarlane, Michele Orini, Charlotte Manisty, Peter Kellman, Rhodri H. Davies, Pier D. Lambiase, Christopher Nguyen, Jurgen E. Schneider, Maite Tome, Gabriella Captur, Erica Dall'Armellina, James C. Moon, Luis R. Lopes
Summary: In patients with hypertrophic cardiomyopathy, alterations in myocardial microstructure and microvascular disease have been found to occur early in the disease process. These changes serve as potential early phenotype biomarkers for disease detection and management.
Article
Cardiac & Cardiovascular Systems
Rebecca K. Hughes, Claudia Camaioni, Joao B. Augusto, Kristopher Knott, Ellie Quinn, Gabriella Captur, Andreas Seraphim, George Joy, Petros Syrris, Perry M. Elliott, Saidi Mohiddin, Peter Kellman, Hui Xue, Luis R. Lopes, James C. Moon
Summary: This study revealed that regional and global impaired myocardial perfusion can occur in HCM mutation carriers, even in the absence of significant hypertrophy or scarring.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Bradley S. Lander, Yanling Zhao, Kohei Hasegawa, Mathew S. Maurer, Albree Tower-Rader, Michael A. Fifer, Muredach P. Reilly, Yuichi J. Shimada
Summary: This multicenter case-control study demonstrates that plasma proteomics profiling can effectively distinguish patients with and without late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM). By identifying patients with a high pre-test probability of having LGE, this study lays the groundwork for establishing a panel of circulating protein biomarkers to improve clinical decision-making and utilization of cardiac magnetic resonance imaging (CMR).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yun Zhao, Lu Huang, Chenhe Li, Dazhong Tang, Yi Luo, Chunlin Xiang, Xiaoyue Zhou, Jing Fang, Xiang Wei, Liming Xia
Summary: TA-BSM can improve left ventricular function and myocardial perfusion in HOCM patients, although still lower than healthy controls. Age, weight of resected myocardium, maximum wall thickness, late gadolinium enhancement, and Delta LVOT pressure gradient were significantly associated with the rate of Slope(max) change in HOCM.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Haneen Ismail, Andrew J. J. Bradley, Jannet F. F. Lewis
Summary: This review examines the role of cardiac imaging, including echocardiography, cardiac MRI, and cardiac CT, in evaluating and managing pregnant women with valvular diseases, hypertrophic cardiomyopathy, and aortic pathology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Gherardo Finocchiaro, Nabeel Sheikh, Ornella Leone, Joe Westaby, Francesco Mazzarotto, Antonis Pantazis, Cecilia Ferrantini, Leonardo Sacconi, Michael Papadakis, Sanjay Sharma, Mary N. Sheppard, Iacopo Olivotto
Summary: Myocardial disarray is characterized by disorganized spatial distribution of cardiomyocytes, without physiological fiber alignment. While initially thought to be specific to hypertrophic cardiomyopathy, recent studies suggest disarray may be present in other cardiac conditions. Further research is needed to determine the diagnostic value and clinical significance of disarray in HCM.
