Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 47, Pages 9173-9181Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb01453k
Keywords
-
Categories
Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [31370960, 31100678]
- National Science and Technology Pillar Program during the Twelfth Five-years Plan Period [2012BAD32B01]
- 111 Project [B14018]
- Program of Shanghai Leading Academic Discipline Project [B502]
- National Special Fund for State Key Laboratory of Bioreactor Engineering [2060204]
Ask authors/readers for more resources
The development of injectable calcium phosphate cements (ICPC) represents a promising approach for minimally invasive surgical techniques. However, the undesirable anti-washout property and slow setting time of ICPC greatly hinder its clinical application. Xanthan gum (XG) has strong hydrophilic, shape retention and rheological properties. In this study, a fast setting and anti-washout injectable calcium-magnesium phosphate cement (fa-ICMPC) was developed by introducing XG, as an anti-washout agent, and magnesium phosphate cement (MPC) into calcium phosphate cement (CPC). The bone-regenerative capacity and the bioresorption of the fa-ICMPC were also investigated by injecting it directly into a rabbit thigh bone defect. The result showed that XG imparted anti-washout properties to the fa-ICMPC and enhanced the injectability of the fa-ICMPC. With the protection of thick viscous films formed by XG, the setting of the fa-ICMPC was not disturbed but accelerated due to the synergistic effect of MPC. The result demonstrated that fa-ICMPC was not crumbled and could fill the defects tightly. The newly-formed bone tissue grew into fa-ICMPC along with the degradation of the materials. In short, the fa-ICMPC exhibited potent anti-washout properties, fast setting, improved injectability, good biodegradability and osteoconductivity, and has the potential to repair bone defects by minimal invasive treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available