Article
Pharmacology & Pharmacy
Narimane Lammari, Tanguy Demautis, Ouahida Louaer, Abdeslam Hassen Meniai, Herve Casabianca, Chawki Bensouici, Gilles Devouassoux, Hatem Fessi, Abderrazzak Bentaher, Abdelhamid Elaissari
Summary: A new polymethyl methacrylate based nanocapsules were developed as carriers of Saussurea lappa essential oil, showing promising biological functions such as anti-inflammatory, anti-Alzheimer, and antidiabetic effects. Further studies, including in vivo studies, pharmacokinetic properties, bioavailability, and metabolic pathways, are needed for a comprehensive understanding.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Food Science & Technology
Hivda Ulbegi Polat, Muge Serhatli, Arzu Tas Ekiz, Irem Abaci, Ozge Aksoy, Gamze Cakirca, Saban Tekin, Abdulmajeed Aziz Hamoud Al-Zendani, Mohammed Abdulmajeed Aziz Al-Zendani, Omer Korkmaz, Celalettin Peru
Summary: This study investigates the antiviral activity of a plant extract derived from the roots of Saussurea lappa against SARS-CoV-2 infection. Vero E6 cells are used to test the neutralizing effect of the extract, and a challenge experiment in mice is conducted. The results demonstrate that the extract protects mice against SARS-CoV-2 in 90% of the cases.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ravneet Kaur, Shivalika Pathania, Monika Kajal, Vasundhara Thakur, Jagdeep Kaur, Kashmir Singh
Summary: A study was conducted to understand the regulatory mechanism of costunolide biosynthesis in Saussurea lappa. Transcriptome, miRNA, and degradome analyses revealed the roles of miR171c.1 and sla-miR121 as key regulators in connecting different pathways involved in costunolide biosynthesis.
Review
Nutrition & Dietetics
Huiyu Luo, Junbin Chen, Chuhong Su, Longying Zha
Summary: Atherosclerosis is a chronic inflammatory disease that poses a threat to human health. Saponins, a type of phytochemicals, exhibit multiple bioactivities that are beneficial for the prevention and treatment of atherosclerosis.
Article
Plant Sciences
Sheng-Tian Lai, Ting Zhang, Hong-Qing Wang, Jun Xie, Jian-Bo Liu, Ruo-Yun Chen, Jie Kang
Summary: Two new sesquiterpene dimers, named Lappadimers A and B, were isolated from the roots of Saussurea lappa. Their structures were determined by spectroscopic methods. It was found that they exhibited potential anti-inflammatory activity and could decrease the LPS-induced NO levels in murine macrophage.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Rehab M. Elgharabawy, Ibrahim El Tantawy El Sayed, Nada Abd-Allah Rezk, Ehab Tousson
Summary: The study found that costus root had protective effects against EST-induced cardiac toxicity, improving cardiac toxicity, lipid profiles, electrolytes, and apoptosis, and providing protection against EST. This suggests the potential benefits of costus as an adjuvant in the prevention and treatment of cardiac toxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Shinya Okubo, Tomoe Ohta, Hideaki Fujita, Yukihiro Shoyama, Takuhiro Uto
Summary: The study found that CL and DCL from the root of Saussurea lappa inhibit the autophagy process in HepG2 cells, leading to the accumulation of LC3 and p62. These results suggest the potential of CL and DCL as autophagy inhibiting agents for liver cancer therapy, warranting further investigation.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Tao Wu, Xin-Jian Yan, Tian-Rong Yang, Yun-Fen Wang, Jing-Yi He, Yang Feng, Li-Hua Su, Hao Chen, Min Xu
Summary: This study presents a concept of structure-guided isolation to find candidate active molecules from herbs. The establishment of an anti-viral sesquiterpene networking led to the discovery of potential new anti-HBV sesquiterpenes. Through the analysis of an ethanol extract of Saussurea lappa, several new sesquiterpenes were isolated and evaluated for their potency against hepatitis B virus.
Article
Environmental Sciences
Ehab Tousson, Doaa M. El-Gharbawy
Summary: This study investigated the impact of costus root extract on oxidative stress, heart structure, and functions induced by copper oxide nanoparticles (CuO NPs). The results showed that CuO NPs administration increased oxidative stress and affected heart parameters, while treatment with costus root extract significantly improved these parameters and heart structure and functions.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Applied
Jaeeun Yu, Hana Lee, Huijin Heo, Heon Sang Jeong, Jeehye Sung, Junsoo Lee
Summary: This study found that exogenous sucrose treatment had a negative impact on the growth of mung bean sprouts, but increased the content of polyphenols, flavonoids, gamma-aminobutyric acid, and enhanced antioxidant capacity. Mung bean sprouts treated with 2-3% sucrose also showed improvement in insulin resistance and oxidative damage in cells.
Review
Plant Sciences
Shalika Rathore, Pritam Debnath, Rakesh Kumar
Summary: Costus, also known as Saussurea costus, is an important herb endemic to the Himalayan region, traditionally used in herbal medications. However, escalating demand and unscientific collection practices have led to the decline in the wild plant population.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2021)
Article
Biochemistry & Molecular Biology
Kittiya Phinyo, Khomsan Ruangrit, Jeeraporn Pekkoh, Yingmanee Tragoolpua, Thida Kaewkod, Kritsana Duangjan, Chayakorn Pumas, Nakarin Suwannarach, Jaturong Kumla, Wasu Pathom-aree, Wenhui Gu, Guangce Wang, Sirasit Srinuanpan
Summary: This study comprehensively characterized phytochemicals and evaluated multifunctional bioactivities in the ethanolic extract of cyanobacterium Leptolyngbya sp. KC45. The extract was found to contain chlorophylls, carotenoids, phenolics, and flavonoids. It demonstrated high antioxidant activity, inhibitory effects on enzymes related to diseases, and a strong cytotoxic effect on cancer cells, confirming the apoptosis mechanisms. It has potential applications in various industries.
Article
Chemistry, Multidisciplinary
Mahmoud Moustafa, Mona G. Zaghloul, Mohamed A. Sabry, Walaa S. Aboelmaaty, Refaat B. Hamed, Sherif S. Ebada, Weaam Ebrahim
Summary: Four sesquiterpene lactones and beta-sitosterol were isolated from the methanol extract of Saussurea lappa roots. These compounds showed potential antiviral, antibacterial, and cytotoxic activities. Molecular docking studies suggested similar binding interactions as acyclovir for antiviral activity. The discovery of these compounds highlights their potential as therapeutic agents.
Article
Biochemistry & Molecular Biology
Vasundhara Thakur, Savita Bains, Ravneet Kaur, Kashmir Singh
Summary: The study identified potential transcription factor binding sites in the promoter region of the DPD gene in Saussurea lappa, providing insights into the transcriptional regulation pattern of the costunolide biosynthetic pathway. Yeast one-hybrid assays revealed three TFs from Dof, bHLH, and WRKY families that interacted positively with the DPD gene. Tissue-specific relative gene expression studies supported the linked co-expression of the gene and its interacting TFs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Hajo Idriss, Babeker Siddig, Pamela Gonzalez-Maldonado, H. M. Elkhair, Abbas I. Alakhras, Emad M. Abdallah, Amin O. Elzupir, Pablo H. Sotelo
Summary: This study demonstrates the phytochemical profile, molecular docking, anti-Candida activity, and anti-viral activity of Saussurea costus acetic acid extract. It was found to have active properties inhibiting SARS-CoV-2 and demonstrated significant antimicrobial and antiviral activity.
Article
Ecology
N. Khalid, A. M. Khan, R. Qureshi, Z. Saqib, N. Zahid, R. W. Bussmann
Summary: This study explores the interactions between the flowering phenology of vascular plants and climate variations in the western Himalayan region of Dhirkot, Pakistan. The results reveal that climate variables play a significant role in determining the timing of flowering, with temperature, precipitation, wind speed, and soil moisture being important factors. The study highlights the potential detrimental effects of future temperature increases on the delicate Himalayan ecosystem.
APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH
(2022)
Article
Anatomy & Morphology
Farheen Gul, Khafsa Malik, Rahmatullah Qureshi, Mushtaq Ahmad, Lubna Ansari, Muhammad Zafar, Sabtain Hussain, Sidra Khalid, Muhammad Imran, Neelam Rashid
Summary: The study investigated the palyno-morphological features of 13 Asteraceous species from District Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan, using light and scanning electron microscopy. Different pollen characters such as shape, size, aperture, exine thickness, and sculpturing were observed. This research highlights the importance of pollen morphology in the taxonomy and classification of Asteraceous flora at various levels.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Anatomy & Morphology
Wajiha Seerat, Abida Akram, Rahmatullah Qureshi, Ghulam Yaseen, Tariq Mukhtar, Nafeesa Qudsia Hanif
Summary: This study successfully isolated and characterized A. flavus from maize seeds, which will be beneficial for future proper identification of aflatoxin sources by farmers, researchers, and traders.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Plant Sciences
Shahid Ali, Rahmatullah Qureshi, Naveed Iqbal Raja, Muhammad Azam Khan
Summary: The vegetation analysis of District Chakwal in Pakistan revealed that altitude, moisture, and soil pH are significant factors influencing the formation of plant communities. Due to excessive utilization of vegetation by local inhabitants, proper management is urgently needed.
PAKISTAN JOURNAL OF BOTANY
(2022)
Article
Multidisciplinary Sciences
Mubashrah Munir, Sehrish Sadia, Adnan Khan, Bakht Zareen Rahim, Brian Gagosh Nayyar, Khawaja Shafique Ahmad, Arshad Mahmood Khan, Ishrat Fatima, Rahmatullah Qureshi
Summary: This study collected ethnobotanical data on plant resources in rural areas of Pakistan, revealing unique traditional knowledge among native people. The research findings suggest that traditional knowledge of medicinal plants is declining due to the popularity of allopathic medicine, highlighting the importance of conservation and documentation of this valuable heritage.
Article
Neurosciences
Farhana Amin, Sobia Tabassum, Sadia Sarwar, Rahmatullah Qureshi, Muhammad Sohaib Khalid, Naveeda Riaz, Wahidah H. Al-Qahtani, Iram Murtaza
Summary: This study evaluated the antioxidant, anti-inflammatory, and anticonvulsant potential of Otostegia limbata L. The methanolic extract showed significant antioxidant activity and anticonvulsant effect. It also downregulated the expression of inflammatory cytokines and protected neurons.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Veterinary Sciences
Sabith Rehman, Zafar Iqbal, Rahmatullah Qureshi, Inayat Ur Rahman, Shazia Sakhi, Imran Khan, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Khalid F. Almutairi, Elsayed Fathi Abd Allah, Niaz Ali, Muhammad Azhar Khan, Farhana Ijaz
Summary: Domestic animals play a vital role in human civilization. The tribes of North Waziristan have extensive knowledge of ethnoveterinary medicines and use local plants to treat animal diseases.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Sabith Rehman, Zafar Iqbal, Rahmatullah Qureshi, Inayat Ur Rahman, Muazzam Ali Khan, Mohamed M. A. Elshaer, Dunia A. Al Farraj, Mohamed S. Elshikh, Muhammad Younas, Shazia Sakhi, Ghazala Nawaz, Niaz Ali, Fazal Rahim, Hamid Ali, Imran Khan, Siddiq Ur Rahman, Noha Abu Bakr M. Elsaid
Summary: This quantitative study conducted in the tribal areas of North Waziristan is the first ever to focus on ethnogynaecology, highlighting the importance of traditional herbal remedies for basic medical requirements.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Chemistry, Physical
Hidayat Ullah, Ilham Khan, Ghazala Mustafa, Junaid Shehzad, Murtaza Hasan, Umair Saeed, Sunbal Khalil Chaudhari
Summary: This study investigated the role of SiO2-NPs in mitigating lead toxicity in Ocimum basilicum. The results showed that SiO2-NPs can effectively remove lead from plants by enhancing their antioxidant activity.
Article
Plant Sciences
Majid Ullah, Saeed Gulzar, Mohammad Irfan Ashraf, Rahmatullah Qureshi
Summary: The natural forests of Swat, Khyber Pakhtunkhwa, Pakistan are rapidly declining due to human pressures and mismanagement. A study was conducted to assess the natural regeneration of different tree species in relation to altitude and environmental factors. The results showed that the regeneration percentage varies with elevation and aspect, with higher percentages on the northern aspect. This study highlights the importance of forest regeneration for management and conservation.
PAKISTAN JOURNAL OF BOTANY
(2023)
Article
Green & Sustainable Science & Technology
Muhammad Danish Jamil, Muhammad Waheed, Shamim Akhtar, Nazneen Bangash, Sunbal Khalil Chaudhari, Muhammad Majeed, Mumtaz Hussain, Kishwar Ali, David Aaron Jones
Summary: This study evaluates the diversity and composition of invasive plants in different habitats in Mandi Bahuddin, Punjab, Pakistan. The research highlights the significant connection between the distribution of alien species and environmental factors, and provides a scientific foundation for the development of management strategies for ecological restoration.
Review
Food Science & Technology
Ishrat Fatima, Mubashrah Munir, Rahmatullah Qureshi, Uzma Hanif, Nabila Gulzar, Ali Ahmad Sheikh
Summary: Algae are aquatic photosynthetic organisms that can be used as a potential source of food, feed, medicine, and natural pigments. Various natural pigments, including chlorophylls and carotenes, can be extracted from algae, and they have applications in pharmaceuticals, nutraceuticals, and the food industry. Advanced extraction methods such as Supercritical fluid extraction and Microwave-assisted extraction are currently being used for pigment extraction from algae.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Retraction
Multidisciplinary Sciences
Mubashrah Munir, Sehrish Sadia, Adnan Khan, Bakht Zareen Rahim, Brian Gagosh Nayyar, Khawaja Shafique Ahmad, Arshad Mahmood Khan, Ishrat Fatima, Rahmatullah Qureshi
Article
Chemistry, Multidisciplinary
Gul Rahim, Rahmatullah Qureshi, Ali Hazrat, Bashir Ahmad, Ayaz Ali Khan, Tariq Aziz, Metab Alharbi, Abdulrahman Alshammari
Summary: This study investigated the phytochemical constituents and antimicrobial as well as radical scavenging activities of the leaf extracts from Teucrium stocksianum. The results showed that the extracts exhibited significant inhibitory effects against various human pathogens and possessed antioxidant properties. These findings support the traditional medicinal use of Teucrium stocksianum and have potential implications for the development of new antimicrobial and antioxidant agents.
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
(2023)
Article
Environmental Sciences
Rukhsana Afzal, Abida Akram, Rehmatullah Qureshi, Zahid Akram, Kishwar Sultana Nazir, Muhammad Ikram, Humayun Bashir
Summary: Wild mushroom species were collected, identified, and categorized in hilly areas of Pakistan. The study found a considerable number of oyster mushroom species and validated their diversity and polymorphism using molecular markers and ISSR analysis.
FRESENIUS ENVIRONMENTAL BULLETIN
(2022)