Article
Oncology
Shitong Zhang, Xianhu Fu
Summary: The study explores the expression and mechanism of PCDH7 in cervical cancer and evaluates its clinical prognostic significance. PCDH7 is downregulated in cervical cancer tissues and cell lines, and its low expression is associated with a low survival rate. PCDH7 may be used as an independent prognostic factor for cervical cancer, impacting cancer cell proliferation, migration, and invasion.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Cell Biology
Xiaosheng Wu, Hao Wang, Danping Zhu, Yixia Chai, Jing Wang, Weiyu Dai, Yizhi Xiao, Weimei Tang, Jiaying Li, Linjie Hong, Miaomiao Pei, Jieming Zhang, Zhizhao Lin, Jide Wang, Aimin Li, Side Liu
Summary: This study reveals the mechanism of how deubiquitinating enzyme USP3 promotes tumor progression and metastasis in gastric cancer. The downstream targets of USP3, COL9A3 and COL6A5, are identified using isobaric tags technique. The results show that USP3 interacts with and stabilizes COL9A3 and COL6A5 through deubiquitination, playing a crucial role in the oncogenic activity of USP3 both in vitro and in vivo.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Shu-fan Ji, Sheng-Lian Wen, Yu Sun, Pi-Wei Huang, Hao Wu, Mao-lin He
Summary: STIL is closely associated with the proliferation and invasion of osteosarcoma, and may promote the progression of osteosarcoma by regulating the expression of key genes such as CDK1, CCNB2, CDC20, CCNA2, BUB1, and AURKB.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Beiwei Liang, Chunlai Li, Zhan Zhou, Yubo Xie
Summary: This study aimed to investigate the effect of hydromorphone on the growth of human gastric cancer cells. The results showed that within a certain concentration range, hydromorphone can suppress the growth of human gastric cancer cells, and the inhibitory effect is enhanced with longer incubation time and higher concentrations. Hydromorphone inhibits the growth of human gastric cancer cells through cell cycle arrest and induction of apoptosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cheng Yan, Huijie Yang, Peng Su, Xin Li, Zhongbo Li, Dehai Wang, Yifeng Zang, Tianshi Wang, Ziping Liu, Zhuocong Bao, Shuxiao Dong, Ting Zhuang, Jian Zhu, Yinlu Ding
Summary: Gastric cancer is a deadly disease and recent studies have shown that abnormality in the Hippo/YAP axis plays a critical role in its development. Inhibiting the deubiquitination of YAP protein could be a potential new therapeutic target for gastric cancer.
Review
Medicine, Research & Experimental
Xiao Liu, Yonghua Tong, Ding Xia, Ejun Peng, Xiaoqi Yang, Hailang Liu, Tao Ye, Xinguang Wang, Yu He, Zhangqun Ye, Zhiqiang Chen, Kun Tang
Summary: circRNAs play important regulatory roles in PCa, being closely associated with the biological behaviors and clinicopathological features of tumors, and may serve as potential diagnostic, prognostic, and therapeutic targets for PCa.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Atsushi Sugimoto, Tomohisa Okuno, Gen Tsujio, Tomohiro Sera, Yurie Yamamoto, Koji Maruo, Shuhei Kushiyama, Sadaaki Nishimura, Kenji Kuroda, Shingo Togano, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Masakazu Yashiro
Summary: The study found high expression of Tks5 in PMCs of advanced-stage gastric cancer patients, with positive expression being associated with greater tumor depth and increased rate of peritoneal recurrence. Tks5 might serve as a useful predictor for peritoneal recurrence in GC patients.
Article
Biochemistry & Molecular Biology
Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou
Summary: This study revealed that CST1 promotes gastric cancer metastasis and progression by regulating GPX4 and inhibiting ferroptosis. High CST1 expression is associated with poor prognosis, and it inhibits ferroptosis by stabilizing GPX4 and reducing intracellular ROS levels, enhancing migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells. CST1 may serve as a new oncological marker and therapeutic target for gastric cancer metastasis.
Article
Mathematical & Computational Biology
Li Jiang, Lie Yang, Yun Dai, Guangming Yang, Shuyin Pan
Summary: The study revealed that indicators such as POT1-AS1, TIMP-1, VEGF, and Ki-67-Li are closely related to the development and prognosis of gastric cancer, further elucidating the important roles in the growth process of tumors.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Review
Oncology
Ying Liu, Wei Ding, Wanpeng Yu, Yuan Zhang, Xiang Ao, Jianxun Wang
Summary: Gastric cancer is a prevalent malignant tumor with high morbidity and mortality due to a lack of novel therapeutic strategies. Long non-coding RNAs play crucial roles in various aspects of gastric cancer pathogenesis and may serve as potential biomarkers for diagnosis, prognosis, and therapeutic targets.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Cell Biology
Fang Liu, Yanfen Shi, Zuolong Liu, Ziyi Li, Wei Xu
Summary: Evidence has shown that miRNAs are crucial in the tumorigenesis and progression of various cancers, including gastric cancer, with miR-10a and miR-10b identified as key players in gastric carcinogenesis. Targeting the miR-10 family could be a promising approach for treating gastric cancer, as it regulates multiple aspects of cancer cell behavior and various compounds have shown antitumor activity by targeting these miRNAs.
Article
Food Science & Technology
Feng Gao, Shihai Yan, Zheng Sun, Jia Wang
Summary: This study aimed to determine the effects and mechanism of action of muscone on the biological activity of gastric cancer cell lines SGC-7901 and MGC-803, and found that muscone can suppress the biological activity of SGC-7901 and MGC-803 gastric cancer cells in vitro by regulating miRNA-145.
FOOD SCIENCE & NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Jingwen Yuan, Shahid Ullah Khan, Jiajun Luo, Yue Jiang, Yu Yang, Junfeng Yan, Qiang Tong
Summary: Biosynthetic silver nanoparticles (b-Ag) exhibit strong cytotoxic effects on gastric cancer (GC) and enhance the inhibitory effect of 5-fluorouracil (5F) on GC by promoting cell apoptosis and increasing intracellular ROS generation.
Article
Medical Laboratory Technology
Jianzhong Wu, Ling Gao, Hong Chen, Xiaojun Zhou, Xialiang Lu, Zhongqi Mao
Summary: This study revealed that in poorly differentiated gastric cancer (PDGC), the upregulation of LINC02535 expression contributes to cell proliferation, migration, invasion, and wound healing, while its inhibition facilitates cell apoptosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Yuhai Zhang, Yuling Hong, Dan Wang, Linshan Duan, Yanling Liu, Long Li, Di Liu, Kunbin Zhuang, Chaoxin Wei, Guogeng Zheng, Chunyong Huo, Guoyan Liu
Summary: Recent studies have shown that the circular RNA hsa_circ_0076305 plays a crucial role in gastric cancer development by regulating cell proliferation and migration, indicating a potential target for cancer therapy.
