Article
Oncology
Shreya Desai, Michelle J. Zhu, Ilana Lapidos-Salaiz
Summary: Low- and middle-income countries bear a high burden of preventable cervical cancer cases and deaths, with human papillomavirus DNA-based testing increasingly being the preferred screening method. This commentary discusses next steps and key considerations for the expansion of this screening approach.
Article
Virology
Emel Yilmaz, Carina Eklund, Camilla Lagheden, Karin Dahlin Robertsson, Marina Lilja, Miriam Elfstrom, Laila Sara Arroyo Muhr, Joakim Dillner
Summary: This study provides the first global overview of the proficiency of HPV testing services for cervical cancer screening. The results indicate a high level of sensitivity and few false positives, but specificity still needs further improvement.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Obstetrics & Gynecology
K. F. Bennett, J. Waller, E. McBride, A. S. Forster, G. Di Gessa, H. Kitchener, L. A. Marlow
Summary: The study found that receiving an HPV-positive result following primary HPV testing can cause short-term psychosexual distress, especially among women with HPV-positive and normal or abnormal cytology results.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Jacquelyn Dillon, Ling Chen, Alexander Melamed, Caryn M. St Clair, June Y. Hou, Fady Khoury-Collado, Allison Gockley, Melissa Accordino, Dawn L. Hershman, Jason D. Wright
Summary: Cervical cancer screening is frequently overused among average-risk Medicaid beneficiaries, with women who do not undergo screening also unlikely to receive routine gynecological examinations.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Zeni Wu, Tingyuan Li, Yongli Han, Mingyue Jiang, Yanqin Yu, Huifang Xu, Lulu Yu, Jianfeng Cui, Bin Liu, Feng Chen, Jian Yin, Xun Zhang, Qinjing Pan, Youlin Qiao, Wen Chen
Summary: This study developed a more accurate model for cervical cancer screening, utilizing multiple predictors and conducting external validations in different cohorts. The results showed that the model had better clinical performance compared to routine screening methods, leading to reduced referral rates.
Article
Medicine, General & Internal
Yanxia Zhao, Heling Bao, Lan Ma, Bo Song, Jiangli Di, Linhong Wang, Yanqiu Gao, Wenhui Ren, Shi Wang, Hai-Jun Wang, Jiuling Wu
Summary: The study evaluated the effectiveness of HPV testing in the national cervical cancer screening programme in China. Results showed that HPV testing had higher CIN2+ detection rate and PPV compared to cytology, with colposcopy referrals differing by income status in different regions.
Article
Obstetrics & Gynecology
C. Acuti Martellucci, S. Nomura, D. Yoneoka, P. Ueda, J. M. L. Brotherton, K. Canfell, M. Palmer, L. Manzoli, P. Giorgi Rossi, A. De Togni, C. Palmonari, A. Califano, E. Saito, M. Hashizume, K. Shibuya
Summary: This retrospective cohort study in Italy assessed the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities detected during subsequent screenings. Results showed that women who received at least one dose of the HPV vaccine were significantly less likely to have abnormal cervical cytology. Overall, catch-up HPV vaccination almost halved the risk of cytological abnormalities in organized cervical screening programmes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Immunology
Howard D. Strickler, Marla J. Keller, Nancy A. Hessol, Isam-Eldin Eltoum, Mark H. Einstein, Philip E. Castle, L. Stewart Massad, Lisa Flowers, Lisa Rahangdale, Jessica M. Atrio, Catalina Ramirez, Howard Minkoff, Adaora A. Adimora, Igho Ofotokun, Christine Colie, Megan J. Huchko, Margaret Fischl, Rodney Wright, Gypsyamber D'Souza, Jason Leider, Olga Diaz, Lorraine Sanchez-Keeland, Sadeep Shrestha, Xianhong Xie, Xiaonan Xue, Kathryn Anastos, Joel M. Palefsky, Robert D. Burk
Summary: The study found that in women living with HIV, primary human papillomavirus screening (PHS) combined with reflex HPV16/18 genotyping can reduce unnecessary colposcopies, potentially serving as an alternative to co-testing.
CLINICAL INFECTIOUS DISEASES
(2021)
Editorial Material
Oncology
Eduardo Franco
Summary: The American Cancer Society (ACS) believes that the time has come for primary human papillomavirus (HPV) screening in the United States, but it requires educating the public and healthcare providers and overcoming logistical barriers. ACS is taking the lead by utilizing its resources to promote primary HPV screening in the US and sharing best practices from other countries through its Primary HPV Screening Initiative.
Article
Medicine, General & Internal
Oscar Holmstrom, Nina Linder, Harrison Kaingu, Ngali Mbuuko, Jumaa Mbete, Felix Kinyua, Sara Tornquist, Martin Muinde, Leena Krogerus, Mikael Lundin, Vinod Diwan, Johan Lundin
Summary: This study aimed to determine the feasibility of implementing artificial intelligence-supported digital microscopy diagnostics in a resource-limited setting for the analysis of Pap smear samples. The findings showed that the system was highly sensitive in detecting cervical cellular atypia, especially for high-grade lesions, suggesting that advanced digital microscopy diagnostics with AI support can be effectively used in rural areas for cervical cancer screening.
Article
Public, Environmental & Occupational Health
Laura A. Marlow, Martin Nemec, Jessica Barnes, Jo Waller
Summary: This study tested the impact of different messages about extending cervical screening intervals on acceptance. The groups who received additional information were more likely to find the change acceptable. Emphasizing interval safety, test accuracy and cell changes resulted in more positive attitudes and a better understanding. However, those who were up-to-date with screening or had previous abnormal results were less accepting of longer intervals.
PATIENT EDUCATION AND COUNSELING
(2022)
Review
Oncology
Nikoletta Daponte, George Valasoulis, Georgios Michail, Ioulia Magaliou, Athina-Ioanna Daponte, Antonios Garas, Ioanna Grivea, Dimitrios P. Bogdanos, Alexandros Daponte
Summary: Dynamic adaptations in global health during the SARS-CoV-2 pandemic have led to the increased use of self-sampling for cervical screening, which plays a crucial role in improving screening uptake and coverage. Self-sampling is an important component of the WHO's global strategy to eliminate cervical cancer and has the potential to reduce health disparities. However, there is a need for effective strategies to ensure follow-up testing and management for individuals with positive self-sampling results.
Review
Oncology
Biyuan Xing, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao
Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jennifer Margaret Roberts, Dorothy A. Machalek, Bethan C. Butler, Joanne Crescini, Suzanne M. Garland, Annabelle Farnsworth
Summary: In Australia's HPV-based cervical screening program, the risk of histological high-grade abnormality decreased with age in women with oncogenic HPV. This study followed HPV16/18 positive women aged 55 years and over for up to 3 years to determine the proportion with histological high-grade abnormality and its correlation with liquid-based cytology result and prior screening history. The results showed that age, screening history, and cytology result are important factors to consider in managing screen-detected abnormalities in HPV-based cervical screening programs.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Veronique Bouvard, Nicolas Wentzensen, Anne Mackie, Johannes Berkhof, Julia Brotherton, Paolo Giorgi-Rossi, Rachel Kupets, Robert Smith, Silvina Arrossi, Karima Bendahhou, Karen Canfell, Z. Mike Chirenje, Michael H. Chung, Marta del Pino, Silvia de Sanjose, Miriam Elfstrom, Eduardo L. Franco, Chisato Hamashima, Francoise F. Hamers, C. Simon Herrington, Raul Murillo, Suleeporn Sangrajrang, Rengaswamy Sankaranarayanan, Mona Saraiya, Mark Schiffman, Fanghui Zhao, Marc Arbyn, Walter Prendiville, Blanca I. Indave Ruiz, Isabel Mosquera-Metcalfe, Beatrice Lauby-Secretan
Summary: This article reviews the best methods of screening for cervical cancer, with HPV nucleic acid testing being superior whether used alone or in combination with other methods.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
