Article
Biochemistry & Molecular Biology
Benjamin Wei Rong Tay, Daniel Q. Huang, Muthiah Mark, Neo Wee Thong, Lee Guan Huei, Lim Seng Gee, Low How Cheng, Lee Yin Mei, Prem Thurairajah, Lim Jia Chen, Cheng Han Ng, Wen Hui Lim, Darren Jun Hao Tan, Da Costa Maureen, Kow Wei Chieh Alfred, Iyer Shridar Ganpathi, Tan Poh Seng, Dan Yock Young
Summary: This study compared the clinical outcomes of TACE and RFA in early hepatocellular carcinoma (HCC) and found no significant difference in overall survival, time to progression, and number of treatment sessions in tumors less than 3 cm. However, RFA had a significantly higher chance of a complete response.
Article
Medicine, General & Internal
Elles M. F. van de Voort, Gerson M. Struik, Linetta B. Koppert, Adriaan Moelker, Reno Debets, Glenn Yo, Maura J. P. Macco, Renata H. J. A. Sinke, Martine Franckena, Erwin Birnie, Cornelis Verhoef, Taco M. A. L. Klem
Summary: Breast cancer is a common malignancy with a high survival rate. This study aims to compare the efficacy of radiofrequency, microwave, and cryoablation for potential treatment of breast cancer patients. The phase 2 trial will determine the most effective technique for further testing in a phase 3 trial, with a focus on complete ablation rates and patient outcomes.
Article
Oncology
Melanie A. Kimm, Sophia Kaestle, Matthias M. R. Stechele, Elif Oecal, Lisa Richter, Muzaffer R. Uemuetlue, Regina Schinner, Osman Oecal, Lukas Salvermoser, Marianna Alunni-Fabbroni, Max Seidensticker, S. Nahum Goldberg, Jens Ricke, Moritz Wildgruber
Summary: This study found that local ablative therapies may have systemic effects on circulating immune cells in HCC patients. The levels of mMDSCs increased in almost all patients following local ablation, and there were varying alterations in monocyte subpopulations depending on the type of ablation. Liquid biopsy of circulating monocytes may provide information on the inflammatory response and immune reaction following local ablation.
FRONTIERS IN ONCOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pankaj Gupta, Muniraju Maralakunte, Praveen Kumar-M, Karamvir Chandel, Sreedhara B. Chaluvashetty, Harish Bhujade, Naveen Kalra, Manavjit Singh Sandhu
Summary: The study compared the overall survival and local recurrence following radiofrequency ablation, microwave ablation, and cryoablation for very early and early hepatocellular carcinoma. The results showed that these three methods are equally effective for locoregional treatment of very early and early HCC, and age and tumor size did not influence the treatment effect.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Hashem, S. Sait, D. Nicholson Thomas, C. Watson, S. Moeen, P. Peddu
Summary: The study evaluated the safety and efficacy of transarterial chemoembolisation (TACE) for very early and early stage hepatocellular carcinoma (VES-HCC). The results showed that DEB-TACE is a safe and effective treatment option for VES-HCC patients who are not suitable for thermal ablation or surgery.
CLINICAL RADIOLOGY
(2023)
Article
Oncology
Hong-Tao Hu, Xiao-Hui Zhao, Chen-Yang Guo, Quan-Jun Yao, Xiang Geng, Wen-Bo Zhu, Hong-Le Li, Wei-Jun Fan, Hai-Liang Li
Summary: Local ablation treatment is effective and safe for adjacent pleural lung tumors, achieving complete tumor ablation. However, there are potential adverse events and complications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Gabriele Sorce, Benedikt Hoeh, Lukas Hohenhorst, Andrea Panunzio, Stefano Tappero, Zhe Tian, Andrea Kokorovic, Alessandro Larcher, Umberto Capitanio, Derya Tilki, Carlo Terrone, Felix K. H. Chun, Alessandro Antonelli, Fred Saad, Shahrokh F. Shariat, Francesco Montorsi, Alberto Briganti, Pierre I. Karakiewicz
Summary: This study found that local tumor destruction (LTD) treatment for T1a renal cell carcinoma (RCC) patients is associated with higher cancer-specific mortality (CSM) compared to partial nephrectomy (PN) treatment, especially for patients with tumor size between 3.1 and 4 cm.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Gastroenterology & Hepatology
Sanne N. van Munster, Esther Nieuwenhuis, Raf Bisschops, Hilde Willekens, Bas L. A. M. Weusten, Lorenza Alvarez Herrero, Auke Bogte, Alaa Alkhalaf, Ed B. E. Schenk, Erik J. Schoon, Wouter Curvers, Arjun D. Koch, Pieter Jan F. de Jonge, Tjon J. Tang, Wouter B. Nagengast, Jessie Westerhof, Martin H. M. G. Houben, Stefan Seewald, Martinus J. C. Eijkemans, Jacques J. G. H. M. Bergman, Roos E. Pouw
Summary: A prediction model for visible dysplastic recurrence after successful endoscopic eradication treatment of Barrett's esophagus has been developed and validated externally, showing good discrimination and calibration.
Article
Oncology
Richard E. Fine, Richard C. Gilmore, Jill R. Dietz, Susan K. Boolbol, Michael P. Berry, Linda K. Han, Andrew S. Kenler, Michael Sabel, Kenneth R. Tomkovich, Noam A. VanderWalde, Margaret Chen, Karen S. Columbus, Lisa D. Curcio, Sheldon M. Feldman, Linsey Gold, Lydia Hernandez, Eric R. Manahan, Susan A. Seedman, Rashmi P. Vaidya, Alexander B. Sevrukov, Hussein D. Aoun, Randy D. Hicks, Rache M. Simmons
Summary: The ICE3 trial evaluated the safety and efficacy of breast cryoablation for low-risk early-stage breast cancer in women over 60 years old. The results showed a low rate of ipsilateral breast tumor recurrence and high satisfaction with cosmetic results, suggesting cryoablation as a promising alternative to surgery for selected patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peter Schullian, Edward Johnston, Gregor Laimer, Daniel Putzer, Gernot Eberle, Arno Amann, Maria Effenberger, Manuel Maglione, Martin C. Freund, Alexander Loizides, Reto Bale
Summary: The study assessed the frequency of major complications after multi-probe stereotactic radiofrequency ablation (SRFA) in a large cohort of patients over 15 years and identified risk factors for adverse events. The 30-day mortality after SRFA was 0.5% with an overall major complication rate of 7.4%. History of bile duct surgery/intervention, number of coaxial needles, and tumor location in certain segments were independent prognostic factors for major complications. Experience and adaptations over time contributed to a significant decrease in complications.
EUROPEAN RADIOLOGY
(2021)
Review
Oncology
Yuqing Dai, Ping Liang, Jie Yu
Summary: Percutaneous management of breast cancer is a promising alternative treatment for patients with tumor size <= 2 cm. There is controversy regarding whether percutaneous management can achieve similar effects as surgery for patients with tumor size <= 3 cm, especially in the long term. For patients with tumor size > 3 cm, percutaneous management is still in the early exploration stage but shows potential in treating unresectable cancer.
CURRENT ONCOLOGY REPORTS
(2022)
Review
Oncology
Peiman Habibollahi, Rahul A. Sheth, Erik N. K. Cressman
Summary: Liver cancer is a growing global concern with limited treatment options. The most common treatment methods are ablation techniques such as radiofrequency ablation and microwave ablation. However, difficulties in completely identifying residual cancer cells remain in these procedures, highlighting the need for further advancements in treatment strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martijn R. Meijerink, Alette H. Ruarus, Laurien G. P. H. Vroomen, Robbert S. Puijk, Bart Geboers, Sanne Nieuwenhuizen, Bente A. T. van den Bemd, Karin Nielsen, Jan J. J. de Vries, Krijn P. van Lienden, Birgit Lissenberg-Witte, M. Petrousjka van den Tol, Hester J. Scheffer
Summary: Irreversible electroporation is an effective and relatively safe treatment for colorectal liver metastases measuring 5.0 cm or smaller, especially when unsuitable for surgical resection or thermal ablation. The study showed a 1-year LTP-free survival rate of 68% post-IRE, with good local control and a median overall survival of 2.7 years.
Review
Gastroenterology & Hepatology
Vincenza Granata, Roberta Grassi, Roberta Fusco, Andrea Belli, Raffaele Palaia, Gianpaolo Carrafiello, Vittorio Miele, Roberto Grassi, Antonella Petrillo, Francesco Izzo
Summary: The study provides an overview and updates on ablative techniques for pancreatic cancer, with findings suggesting the safety of ablative therapies based on 1047 assessed patients. Most studies recommend chemotherapy prior to ablative therapies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Mario Ghosn, Stephen B. Solomon
Summary: Available evidence supports the use of thermal ablation in stage IV NSCLC with limited sites of metastasis, showing improved overall survival and progression-free survival. Radiofrequency ablation and microwave ablation are the most evaluated modalities, with tumor size being a key factor of technical success and efficacy. Optimal management of patients requires a multidisciplinary approach and further randomized controlled trials are needed to refine patient selection criteria for thermal ablation.