☆ 4.5 Article

Psoriatic arthritis and sacroiliitis are associated with increased vascular inflammation by 18-fluorodeoxyglucose positron emission tomography computed tomography: baseline report from the Psoriasis Atherosclerosis and Cardiometabolic Disease Initiative

ARTHRITIS RESEARCH & THERAPY (2014)

Journal

ARTHRITIS RESEARCH & THERAPY

Volume 16, Issue 4, Pages -

Publisher

BMC

DOI: 10.1186/ar4676

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Funding

National Institutes of Health Center
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

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Abstract

Introduction: Psoriasis and psoriatic arthritis (PsA) increase cardiovascular disease (CVD) risk, but surrogate markers for CVD in these disorders are inadequate. Because the presence of sacroiliitis may portend more severe PsA, we hypothesized that sacroiliitis defined by computed tomography (CT) would be associated with increased vascular inflammation defined by 18-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT), which is an established measure of CVD. Methods: Participants (n = 65) underwent whole-body FDG-PET/CT. Metabolic activity of the aorta was measured using the maximal standardized uptake value (SUVmax), a measure of atherosclerotic plaque activity. The primary outcome was aortic vascular inflammation. Linear regression (with beta-coefficients (beta) and P-values reported for PsA and sacroiliitis) was used to adjust for CVD risk factors to determine associations of PsA or sacroiliitis with vascular inflammation. Likelihood ratio testing was performed to evaluate the contribution of sacroiliitis to vascular disease estimation compared to the effects of PsA and traditional CVD risk factors. Results: Vascular inflammation (measured as SUVmax) was greater (P < 0.001) in patients with sacroiliitis (mean +/- SD = 7.33 +/- 2.09) defined by CT compared to those without sacroiliitis (6.39 +/- 1.49, P = 0.038). There were associations between PsA and aortic inflammation (beta = 0.124, P < 0.001) and between sacroiliitis and aortic inflammation (beta = 0.270, P < 0.001) after adjusting for CVD risk factors. Sacroiliitis predicted vascular inflammation beyond PsA and CVD risk factors (chi(2) = 124.6, P < 0.001). Conclusions: Sacroiliitis is associated with increased vascular inflammation detected by FDG-PET/CT, suggesting that sacroiliac joint disease may identify patients at greater risk for CVD. Large, ongoing prospective studies are required to confirm these findings.

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[F-18]-FDG PET in anal canal cancer: a systematic review and meta-analysis

Seyed Ali Mirshahvalad, Aruz Mesci, Vanessa Murad, Andres Kohan, Claudia Ortega, Patrick Veit-Haibach, Ur Metser

Summary: This study conducted a meta-analysis to evaluate the diagnostic and prognostic value of PET in anal canal cancer patients. The results showed that PET had high sensitivity and specificity in distinguishing T3/T4 stages and detecting metastatic disease. PET also showed good sensitivity and specificity in therapy response assessment. Furthermore, pre-treatment total metabolic tumour volume was found to be predictive of survival, and complete metabolic response was associated with better prognosis. Overall, PET may be a valuable tool in therapy planning and prognostic assessment for anal canal cancer.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)