Review
Biochemistry & Molecular Biology
Haitao Yu, Yasuo Nagafuchi, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease characterized by immune dysfunction. Clinical and immunological biomarkers are crucial for diagnosing, assessing, and controlling SLE, including novel biomarkers discovered through omics research.
Review
Biochemistry & Molecular Biology
Shingo Nakayamada, Yoshiya Tanaka
Summary: The treatment of rheumatoid arthritis was revolutionized with the use of molecular-targeted drugs that target immunoregulatory molecules. The success of treatment with these drugs prompted the development of molecular-targeted drugs for systemic lupus erythematosus. However, systemic lupus erythematosus is a disease with high heterogeneous immune abnormalities, and diverse cells or molecules can be treatment targets. Thus, the identification of subpopulations based on immune abnormalities is essential for the development of effective treatment.
Article
Urology & Nephrology
Momin H. Alkhatib, Sam Kant, Steven Menez, Laila Lakhani, Christopher John Sperati, Derek M. Fine, Lois J. Arend, Mohamed G. Atta
Summary: This study compared the clinical and prognostic characteristics of thrombotic microangiopathy (TMA) with class IV lupus nephritis in SLE patients. TMA patients showed significant abnormalities in certain laboratory markers and had a worse prognosis.
JOURNAL OF NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
James Greenan-Barrett, Georgia Doolan, Devina Shah, Simrun Virdee, George A. Robinson, Varvara Choida, Nataliya Gak, Nina de Gruijter, Elizabeth Rosser, Muthana Al-Obaidi, Maria Leandro, Michael S. Zandi, Ruth J. Pepper, Alan Salama, Elizabeth C. Jury, Coziana Ciurtin
Summary: Juvenile systemic lupus erythematosus (JSLE) is a form of lupus that occurs before 18 years of age and is associated with more severe disease phenotype, increased morbidity, and mortality compared to adult-onset SLE. Identifying biomarkers specific to JSLE clinical phenotype can lead to better patient management and outcomes. Research into various traditional and novel biomarkers is important for predicting organ involvement and improving treatment strategies for JSLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Makoto Yamaguchi, Masashi Mizuno, Fumiya Kitamura, Shiho Iwagaitsu, Hironobu Nobata, Hiroshi Kinashi, Shogo Banno, Akimasa Asai, Takuji Ishimoto, Takayuki Katsuno, Yasuhiko Ito
Summary: Thrombotic microangiopathy (TMA) and macrophage activation syndrome (MAS) are rare and life-threatening complications of systemic lupus erythematosus (SLE). The association between TMA and MAS in SLE patients has been rarely studied and the diagnosis of these conditions remains challenging. This case report demonstrates the efficacy of eculizumab in treating refractory TMA concurrent with SLE-associated MAS, and suggests the importance of evaluating TMA during the course of SLE-associated MAS.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Ji-Won Kim, Ju-Yang Jung, Sang-Won Lee, Wook-Young Baek, Hyoun-Ah Kim, Chang-Hee Suh
Summary: This study demonstrates that the expression of S100A8 in serum, urine, and saliva is significantly higher in patients with SLE than in healthy controls and is correlated with disease activity markers. Therefore, S100A8 protein could be a potential biomarker for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Ping Yang, Rui Xu, Fei Chen, Shanshan Chen, Adeel Khan, Liang Li, Xiaoshan Zhang, Yanbo Wang, Zhipeng Xu, Han Shen
Summary: This study investigates the gut fungal dysbiosis and ecology in patients with SLE and demonstrates the applicability of fungal species as diagnostic tools for SLE. It suggests that the interaction between the gut fungal mycobiome and the host may contribute to the pathogenesis of the disease.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Bingxue Huang, Dan Feng, Xiaoling Niu, Wenyan Huang, Sheng Hao
Summary: It is crucial to diagnose and evaluate childhood-onset systemic lupus erythematosus (SLE) early and accurately. Serum RGC-32 has been found to be significantly elevated in children with SLE, and it is associated with disease activity and inflammation. RGC-32 may serve as a promising biomarker for the diagnosis and evaluation of SLE.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Mengmeng Xiang, Yilun Wang, Zhanyan Gao, Jie Wang, Qian Chen, Zhan Sun, Jun Liang, Jinhua Xu
Summary: This study used Mendelian randomization to assess the causal correlations between 41 inflammatory cytokines and systemic lupus erythematosus (SLE). The results suggested that CTACK and IL-17 may be associated with the risk of SLE, while several other inflammatory cytokines may be consequences of SLE development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yanming Cui, Jianbo Wei, Xiang Peng
Summary: Vaccination in patients with autoimmune diseases is controversial due to the possibility of thrombotic thrombocytopenic purpura. This case report describes a patient with systemic lupus erythematosus who developed thrombotic thrombocytopenic purpura after rabies vaccination. Prompt identification and treatment saved the patient from danger. This highlights the potential unexpected adverse effects of attenuated vaccines in patients on long-term immunosuppressive drugs and with autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dong-Jin Park, Chang-Seok Yoon, Sung-Eun Choi, Haimuzi Xu, Ji-Hyoun Kang, Shin-Seok Lee
Summary: This study identified hypertension, APS, higher mean daily dose of prednisolone, and higher SDI score as risk factors for TE in SLE patients, while the use of ACEi or ARB was associated with a reduced risk of TE development in these patients.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Mingxuan Chi, Kuai Ma, Yunlong Li, Min Quan, Zhongyu Han, Zhaolun Ding, Xin Liang, Qinxiu Zhang, Linjiang Song, Chi Liu
Summary: Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by multiple immunoregulatory abnormalities that lead to damage to various tissues and organs. Researchers have identified aberrant expression of miRNAs in SLE patients, which may be associated with abnormal immune responses and disease progression in SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Konstantinos Parperis, Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Pulmonary hypertension is commonly seen in patients with systemic lupus erythematosus, presenting with non-specific symptoms and negatively affecting survival. It can result from immune system dysregulation, as well as various other conditions. Early diagnosis and identification of underlying pathogenetic mechanisms are crucial for introducing targeted therapy and preventing irreversible pulmonary vascular damage. The management of pulmonary hypertension in SLE patients is similar to that of idiopathic PAH, but specific diagnostic tools for early diagnosis seem to be unavailable yet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Helena Idborg, Vilija Oke
Summary: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by activation and dysregulation of the immune system. Disturbances in immune pathways and genetic susceptibility are key factors in the development of SLE. Dysregulation of cytokines, particularly interferons, has been extensively studied as potential biomarkers and treatment targets in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Shan Song, Jing-Yuan Zhang, Fang-Yue Liu, He-Yi Zhang, Xiao-Feng Li, Sheng-Xiao Zhang
Summary: This study identified hub genes and key pathways associated with naive and memory B cells, providing novel insights into the behavior of B cells and the pathogenesis of SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Rheumatology
Srijana Davuluri, Bhargavi Duvvuri, Christian Lood, Sara Faghihi-Kashani, Lorinda Chung
Summary: This article discusses the pathogenic mechanisms and available treatments for calcinosis. There are currently no widely effective treatments, but various formulations of sodium thiosulfate show potential efficacy in calcinosis treatment. Early aggressive immunosuppression may prevent calcinosis in juvenile dermatomyositis, but the improvement of established calcinosis is limited. Surgical removal is a viable treatment option.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Ting Wang, Andrew Vasconcellos, John Marken, Sladjana Skopelja-Gardner, Christian Lood, Natalia Giltiay
Summary: This study explores the link between immune complex-driven neutrophil activation and B cell responses in systemic lupus erythematosus (SLE). The results show that immune complexes induce the release of B cell pro-survival factor BAFF by neutrophils, and neutrophils directly promote B cell activation and differentiation. The findings suggest that targeting neutrophil-B cell interactions could be a potential approach for inhibiting pathogenic B cell responses in SLE.
LUPUS SCIENCE & MEDICINE
(2022)
Review
Rheumatology
Srijana Davuluri, Christian Lood, Lorinda Chung
Summary: This study aims to provide updated information on the prevalence, pathogenesis, diagnostics, and therapeutics of calcinosis cutis associated with systemic sclerosis. Recent findings show ethnic and geographical differences in the prevalence of calcinosis, and long-term use of proton pump inhibitors may increase the risk. Few observational studies have shown mild benefit with minocycline and topical sodium thiosulfate. Surgical treatment remains the most effective therapy.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Review
Rheumatology
Yann L. C. Becker, Bhargavi Duvvuri, Paul R. Fortin, Christian Lood, Eric Boilard
Summary: Mitochondria play crucial roles in rheumatic diseases, and understanding their functions and dysfunctions can lead to novel therapeutic strategies.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Rheumatology
Despina Michailidou, Linda Johansson, Runa Kuley, Ting Wang, Payton Hermanson, Solbritt Rantapaa-Dahlqvist, Christian Lood
Summary: The study aimed to evaluate the increased levels of neutrophil activation markers in PMR patients. The results showed that calprotectin and neutrophil extracellular traps (NETs) were elevated in PMR patients, and neutrophil activation was associated with immune complexes and Fc gamma RIIA. The levels of immune complexes correlated with the expression of CD66b and CD11b, and decreased after glucocorticoid therapy. Calprotectin can be used as a biomarker for treatment response in PMR patients.
Article
Rheumatology
Richard E. Moore, Ting Wang, Bhargavi Duvvuri, Marie L. Feser, Kevin D. Deane, Joshua J. Solomon, J. Lee Nelson, M. Kristen Demoruelle, Christian Lood
Summary: This study investigated the presence and significance of antimitochondrial antibodies (AMAs) in patients with rheumatoid arthritis (RA). The results showed that AMA levels were elevated in RA patients and associated with disease severity and progression.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Lesley Ann Saketkoo, Antonia Valenzuela, Susan Kim, Liza J. McCann, Christian Lood, Dawn M. Wahezi, Victoria P. Werth, Belina Yi, Helene Alexanderson, Susan Maillard, Clarissa Pilkington, Kim Fligelstone, Barbara Limbach, Amir B. Orandi, Malin Regardt, Anne-Marie Russell, Srijana Davuluri, Ingrid deGroot, Floranne Ernste, Julie J. Paik, Carlos A. von Muhlen, Mazen M. Dimachkie, Pedro M. Machado, Elie Naddaf, Barbara M. Shafranski, Latika Gupta, Francesco Zulian, Lorinda Chung
Letter
Rheumatology
Richard Moore, Ting Wang, Marina Barguil Macedo, Christian Lood
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
A. I. Khadjinova, X. Wang, A. Laine, K. Ukadike, M. Eckert, A. Stevens, A. A. Bengtsson, C. Lood, T. Mustelin
Summary: This study found that patients with systemic lupus erythematosus (SLE) express HERV-K proviruses and that the encoded Env protein of this virus can elicit an immune response in patients, particularly during active disease.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Bhargavi Duvvuri, Lauren Pachman, Gabrielle Morgan, Payton Hermanson, Ting Wang, Christian Lood
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Despina Michailidou, Bhargavi Duvvuri, Runa Kuley, David Cuthbertson, Peter Grayson, Nader Khalidi, Curry Koening, Carol Langford, Carol McAlear, Larry Moreland, Christian Pagnoux, Philip Seo, Ulrich Specks, Antoine Sreih, Kenneth J. Warrington, Tomas Mustelin, Paul Monach, Peter Merkel, Christian Lood
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Despina Michailidou, Linda Johansson, Runa Kuley, Ting Wang, Payton Hermanson, Solbritt Rantapaa-Dahlqvist, Christian Lood
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Yann Becker, Eric Boilard, Emmanuelle Rollet-Labelle, Christian Lood, Anne-Sophie Julien, Joannie Leclerc, Tania Levesque, Murray Urowitz, John Hanly, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Ann E. Clarke, Sasha Bernatsky, Daniel Wallace, David Isenberg, Anisur Rahman, Joan Merrill, Dafna Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela Alarcon, Ronald Van Vollenhoven, Cynthia Aranow, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane Kamen, Anca Askanase, Jill Buyon, Paul R. Fortin
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Srijana Davuluri, Urvashi Kaundal, Christian Lood, Puneet Kapoor, Yumeko Kawano, Stefania Dell'Orso, Zuoming Deng, Zsuzsanna McMahan, Ami Shah, Laura Hummers, Daniel Kastner, Fredrick Wigley, David Fiorentino, Pravitt Gourh, Lorinda Chung
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Ting Wang, Natalia V. Giltiay, Christian Lood, Bobby Kwanghoon Han
ARTHRITIS & RHEUMATOLOGY
(2022)