Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?

The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes – Implications for osteoarthritis

(2011) Kei Imagawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Outcome measures in placebo-controlled trials of osteoarthritis: responsiveness to treatment effects in the REPORT database

(2011) R.H. Dworkin et al.   OSTEOARTHRITIS AND CARTILAGE

The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature

(2011) N.R. Dostrovsky et al.   OSTEOARTHRITIS AND CARTILAGE

Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine

(2011) Nina Ivanovska et al.   ARTHRITIS RESEARCH & THERAPY

Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT

(2010) A. D. Sawitzke et al.   ANNALS OF THE RHEUMATIC DISEASES

A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals

(2010) R. R. Simon et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model

(2010) Kiyohito Naito et al.   LIFE SCIENCES

Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes

(2010) Z.-H. Wen et al.   OSTEOARTHRITIS AND CARTILAGE

OARSI recommendations for the management of hip and knee osteoarthritis

(2010) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes

(2010) Valentina Calamia et al.   ARTHRITIS RESEARCH & THERAPY

Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis

(2009) Joerg Gruenwald et al.   ADVANCES IN THERAPY

Insulin Resistance Induced by Glucosamine in Fructose-fed Rats

(2009) C-S. Chien et al.   HORMONE AND METABOLIC RESEARCH

Development and validation of a HPLC–ES-MS/MS method for the determination of glucosamine in human synovial fluid

(2009) E. Pastorini et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes

(2009) A.R. Shikhman et al.   OSTEOARTHRITIS AND CARTILAGE

The effects of oral glucosamine on joint health: is a change in research approach needed?

(2009) J.A. Block et al.   OSTEOARTHRITIS AND CARTILAGE

10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin

(2009) D.R. McCulloch et al.   OSTEOARTHRITIS AND CARTILAGE

The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination

(2009) C.G. Jackson et al.   OSTEOARTHRITIS AND CARTILAGE

Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training

(2009) S.G. Petersen et al.   OSTEOARTHRITIS AND CARTILAGE

Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis

(2009) Young Ho Lee et al.   RHEUMATOLOGY INTERNATIONAL

The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: A report from the glucosamine/chondroitin arthritis intervention trial

(2008) Allen D. Sawitzke et al.   ARTHRITIS AND RHEUMATISM

Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system

(2008) Olivier Bruyère et al.   BMC MUSCULOSKELETAL DISORDERS

Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants

(2008) EJ Uitterlinden et al.   BMC MUSCULOSKELETAL DISORDERS

Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model

(2008) Francisco Saraiva Silva et al.   CLINICAL RHEUMATOLOGY

Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride

(2008) M. Meulyzer et al.   OSTEOARTHRITIS AND CARTILAGE

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride

(2008) M. Meulyzer et al.   OSTEOARTHRITIS AND CARTILAGE

Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial

(2008) R.M. Rozendaal et al.   OSTEOARTHRITIS AND CARTILAGE

Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials

(2007) O. Bruyere et al.   OSTEOARTHRITIS AND CARTILAGE