Article
Rheumatology
W. Ci, T. Li, J. Du, W. Fang, D. Chen, L. Han, R. Dong, J. Cao, L. Pan
Summary: This study describes the characteristics of B cells and immunoglobulin (Ig) profile in patients with Takayasu's arteritis (TAK). Results showed that the proportion of CD19(+) B cells and levels of IgG were lower in TAK compared to systemic lupus erythematosus (SLE) patients, but higher than healthy controls. CD19(+) B cell counts were higher in TAK patients than in healthy controls. Immunohistochemical staining confirmed CD19(+) B cell and IgG infiltration to the aortic wall in TAK patients. Therefore, B cells may play a role in the pathogenesis of TAK and serum IgG levels could be a useful biomarker for assessing disease activity and treatment response.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Immunology
Wen Jia, Zi-Li Fu, Xia Wang, Jing Luo, Cheng-Lan Yan, Jian-Ping Cao, Jian-Fang Yan-Liu, Guang-Ying Liu, Chong Gao, Xiao-Feng Li, Jian-Fang Xie
Summary: TA patients show a significant decrease in peripheral Treg cells and an increase in Th17 cells compared to healthy controls. Higher levels of IL-6, IL-10, IL-17, and TNF-alpha are associated with disease activity. Treatment results in a noticeable increase in Treg cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Claudia Oana Cobilinschi, Elena Gradinaru, Ioana Saulescu, Nicolae Carstea, Simona Caraiola, Andra Rodica Balanescu, Daniela Opris-Belinski
Summary: This report presents the case of a female patient with Takayasu arteritis and severe coronary involvement. Despite maximal immunosuppressive treatment, she underwent multiple interventions and restenosis. The management of TA patients with coronary involvement remains challenging and requires a combination of drug and interventional techniques.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Taotao Li, Na Gao, Wei Cui, Limin Zhao, Juan Du, Xuemei Shi, Junming Zhu, Zhiyu Qiao, Shichao Guo, Lili Pan
Summary: The study found that the percentages of CD8(+) GranzymeB(+) T cells, CD8(+) Perforie(+) T cells, and CD8(+) IFN-gamma(+) T cells in CD8(+)T cells were higher in TAK patients compared to control group. After 6 months of treatment, the proportion of CD8(+)T cells in lymphocytes were significantly lower in TAK patients than the baseline assessment.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
S. Lee, Y. Eun, H. Kim, J. Lee, E-M Koh, D-K Kim, H-S Cha
Summary: The study identified higher CRP levels and younger age as risk factors for radiographic progression in patients with Takayasu's arteritis. In the high CRP group, younger patients are more likely to experience progression and may require aggressive anti-inflammatory treatment.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Cell Biology
Gao Qing, Wu Zhiyuan, Yu Jinge, Miao Yuqing, Chen Zuoguan, Diao Yongpeng, Yin Jinfeng, Jia Junnan, Guo Yijia, Li Weimin, Li Yongjun
Summary: This study explored the transcriptome of PBMCs in TA patients requiring surgical management, revealing an increase in CD14(+) monocytes and gene expressions related to oxidative stress. This finding may point towards a new treatment and research direction in this field.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Kazuya Kishimoto, Yuji Nozaki, Toshiharu Sakurai, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura
Summary: A 14-year-old male with Crohn's disease developed brachial artery occlusion while being treated for CD, later diagnosed with Takayasu's arteritis. Treatment with corticosteroids initially improved TA symptoms, but a switch to tocilizumab exacerbated CD, highlighting the challenge of managing both diseases simultaneously and the importance of carefully choosing biologics for treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qing Li, Hua Liao, Yue Ren, Dan Yang, Qingping Yun, Zhiyan Wang, Zhen Zhou, Shuang Li, Jianxiu Lian, Hui Wang, Lijun Zhang, Zhonghua Sun, Lili Pan, Lei Xu
Summary: Right ventricular dysfunction was detected in TA-PAI patients without PH, and MR-feature tracking may be an effective method for detecting early cardiac damage in these patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cell Biology
Maria Loginova, Daria Smirnova, Igor Paramonov
Summary: The specific HLA gene sequences of HLA-B*08:01:71, HLA-B*51:382, and HLA-B*55:01:30 are reported.
Article
Rheumatology
P. Guha Sarkar, A. Bansal, S. Tyagi, M. D. Gupta
Summary: This study examined the factors contributing to left ventricular dysfunction in Takayasu's arteritis (TAK). The results showed that both hemodynamic and inflammatory factors play important roles in the pathophysiology of LV dysfunction in TAK patients.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Immunology
Jean Lee, Emily Cullum, Kyle Stoltz, Niklas Bachmann, Zoe Strong, Danielle D. Millick, Lisa K. Denzin, Anthony Chang, Vera Tarakanova, Alexander Chervonsky, Tatyana Golovkina
Summary: This study investigated the role of H2-O in preventing autoimmunity using mouse models predisposed to autoimmune diseases, finding no significant impact on autoimmunity but revealing its importance in controlling a specific virus, MHV68. The findings suggest that the editing function of H2-O in the MHCII peptide repertoire may have evolved as a defense mechanism against prevalent viral pathogens.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Rheumatology
Yu Wei, Cheng Zhao, Jun Liang, Ziyi Jin, Bingzhu Hua, Hong Wang, Huayong Zhang, Xuebing Feng
Summary: The study found that a significant number of Takayasu's arteritis patients experience adverse outcomes during long-term follow-up, with low-dose cyclophosphamide treatment contributing to better prognosis.
CLINICAL RHEUMATOLOGY
(2021)
Article
Peripheral Vascular Disease
E. Mazumdar, R. D. White, I. M. Williams
Summary: The use of TEVAR for acute type B aortic dissection in patients with Takayasu's arteritis may lead to complications, requiring vigilance for iatrogenic issues. Long-term surveillance is crucial post-operation to prevent further arterial complications.
Editorial Material
Cell Biology
Anastasiia Ananeva, Iuliia Sergeeva, Tatiana Ryzhkova, Raushania Gaifullina, Elena Shagimardanova
Summary: Three new HLA alleles, HLA-A*30:201, HLA-B*51:364, and HLA-C*08:241, were identified during routine next generation sequencing.
Article
Rheumatology
Debashish Danda, Ruchika Goel, George Joseph, Sathish T. Kumar, Aswin Nair, Raheesh Ravindran, L. Jeyaseelan, Peter A. Merkel, Peter C. Grayson
Summary: The clinical profile of Asian Indian patients with Takayasu's arteritis showed differences between childhood-onset and adult-onset cases, with childhood-onset patients more likely to have arterial involvement below the diaphragm and higher levels of systemic inflammation, leading to a greater likelihood of achieving remission.
Letter
Rheumatology
Emine Duran, Levent Kilic, Gamze Durhan, Ahmet Cagkan Inkaya, Gulay Sain Guven, Gul Karakaya, Orhan Macit Ariyurek, Omer Karadag
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Erdal Atalay, Berna Oguz, Seher Sener, H. Nursun Ozcan, Erdal Sag, Ummusen Kaya Akca, Muserref Kasap Cuceoglu, Zeynep Balik, Jale Karakaya, Omer Karadag, Ozge Basaran, Ezgi Deniz Batu, Yelda Bilginer, Seza Ozen
Summary: This study found that children with Behcet's disease have increased lower extremity venous wall thickness, not only when they have vascular involvement but also when they do not. Therefore, lower extremity venous wall thickness may be a new criterion for supporting the diagnosis of childhood Behcet's disease.
Article
Allergy
Ozge Can Bostan, Emine Duran, Gulseren Tuncay, Melek Cihanbeylerden, Omer Karadag, Ebru Damadoglu, Gul Karakaya, Ali F. Kalyoncu
Summary: The use of 100 mg mepolizumab in patients with eosinophilic granulomatosis with polyangiitis (EGPA) showed significant improvement in sinonasal and respiratory outcomes.
Article
Peripheral Vascular Disease
Ali Akdogan, Alper Sari, Yusuf Ziya Sener, Metin Oksul, Berkan Armagan, Levent Kilic, Omer Karadag, Sule Apras Bilgen, Ergun Baris Kaya, Sedat Kiraz, Ali Ihsan Ertenli
Summary: This study found that patients with systemic sclerosis (SSc) have lower oxygen delivery (DO2) compared to healthy controls. However, there is no significant difference in DO2 between patients with and without digital ulcers (DUs). This suggests that the contribution of DO2 to the development of DUs is negligible, with microvasculopathy playing a major role in SSc patients with DUs.
MICROVASCULAR RESEARCH
(2023)
Article
Rheumatology
M. Kiraci, E. Bilgin, E. Duran, B. Farisogullari, E. C. Bolek, G. K. Yardimci, Z. Ozsoy, G. Ayan, G. S. Uzun, T. H. Akbaba, B. Balci-Peynircioglu, O. Karadag, A. Akdogan, S. A. Bilgen, S. Kiraz, A. Ertenli, U. Kalyoncu, L. Kilic
Summary: Comparing the features of patients with familial Mediterranean fever (FMF) accompanying axial spondyloarthritis (axSpA) to patients with each condition alone, it was found that patients with FMF + axSpA had earlier onset of axSpA, more severe hip involvement, and higher prevalence of amyloidosis.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Bernhard Hellmich, Beatriz Sanchez-Alamo, Jan H. Schirmer, Alvise Berti, Daniel Blockmans, Maria C. Cid, Julia U. Holle, Nicole Hollinger, Omer Karadag, Andreas Kronbichler, Mark A. Little, Raashid A. Luqmani, Alfred Mahr, Peter A. Merkel, Aladdin J. Mohammad, Sara Monti, Chetan B. Mukhtyar, Jacek Musial, Fiona Price-Kuehne, Marten Segelmark, Y. K. Onno Teng, Benjamin Terrier, Gunnar Tomasson, Augusto Vaglio, Dimitrios Vassilopoulos, Peter Verhoeven, David Jayne
Summary: Since the publication of the EULAR recommendations for the management of AAV in 2016, several clinical trials have been conducted that have the potential to change clinical care. A systematic literature review and expert opinions were used to modify existing recommendations and create new ones. The recommendations provide updated guidance on AAV management.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Obstetrics & Gynecology
Arzu Taghiyeva, Levent Kilic, Murat Cagan, Ertugrul Cagri Bolek, Gozde Kubra Yardimci, Ozgur Ozyuncu, Sule Apras Bilgen, Omer Karadag
Summary: This study aimed to evaluate fertility, early menopause, and pregnancy outcomes of patients with Takayasu's arteritis (TA) before and after diagnosis. The results showed that TA patients had a higher infertility rate compared to the general population in Turkey (12.5% vs 8.6%) and a lower rate of early menopause (16.7% vs 36.1%). Pregnancy following a TA diagnosis had more maternal complications, and fetal complications were common both before and after diagnosis. Chronic inflammation may contribute to increased infertility and fetal complications.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Medicine, General & Internal
Melda Bahap-Kara, Emine Duran, Aygin Bayraktar-Ekincioglu, Omer Karadag
Summary: CT-P10 is the first biosimilar of rituximab approved in Europe for all indications of originator rituximab. This study provides real-life data on treatment changes and adverse events in patients who received oRTX or CT-P10. The results show that CT-P10 is a safe alternative for rituximab therapy.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Rheumatology
Mohamed-Yacine Khitri, Alessandra Bartoli, Georgina Maalouf, Alban Deroux, Carlo Salvarani, Giacomo Emmi, Omer Karadag, Gerard Espinosa, Mathilde Leclercq, Gabriele Simonini, Mathieu Vautier, Patrice Cacoub, David Saadoun
Summary: This study evaluated the efficacy of tocilizumab in patients with refractory Behcet disease. The results showed that 83% of patients responded to tocilizumab, with 60% achieving complete response and 23% achieving partial response. Tocilizumab also significantly reduced steroid dosage and the need for concomitant disease-modifying antirheumatic drugs. However, a small number of patients experienced mild to moderate side effects and serious adverse events.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Julien Culerrier, Yann Nguyen, Omer Karadag, Sule Yasar Bilge, Tuba Demirci Yildrim, Tahir Saygin Ogut, Veli Yazisiz, Cemal Bes, Ayse Celfe, Ayten Yazici, Oznur Sadioglu Cagdas, Andreas Kronbichler, David Jayne, Philipp Gauckler, Alexis Regent, Vitor Teixeira, Sylvain Marchand-Adam, Pierre Duffau, Saskia Ingen- Housz-Oro, Celine Droumaguet, Baptiste Andre, Luminita Luca, Sarah Lechtman, Achille Aouba, Celine Lebas, Amelie Servettaz, Amandine Dernoncourt, Marc Ruivard, Anne-Marie Milesi, Vincent Poindron, Patrick Jego, Roberto Padoan, Paolo Delvino, Frederic Vandergheynst, Christian Pagnoux, Elaine Yacyshyn, Peter Lamprecht, Oliver Flossmann, Xavier Puechal, Benjamin Terrier
Summary: This retrospective multicentre study aimed to investigate the characteristics and outcome of ANCA-associated vasculitis (AAV) induced by anti-thyroid drugs (ATD) compared to primary AAV. The results showed that ATD-induced AAV mainly presented as microscopic polyangiitis (MPA), with the most common manifestations being skin involvement, arthralgia, and glomerulonephritis. However, ATD-induced MPA was less severe and had a lower risk of relapse compared to primary MPA.
Article
Medicine, General & Internal
Onur Keskin, Bayram Farisogullari, Gozde Kubra Yardimci, Burcu Gurbuz, Melike Kole, Erkan Parlak, Omer Karadag, Taylan Kav, Umut Kalyoncu
Summary: This study aimed to determine the effectiveness of adding a simple questionnaire related to the musculoskeletal system to routine outpatient examination to detect undiagnosed axial and peripheral arthropathy in patients with inflammatory bowel disease (IBD). The study found that the DETAIL questionnaire is an effective tool for identifying missed cases of enteropathic arthritis in patients with IBD.
FRONTIERS IN MEDICINE
(2023)
Article
Rheumatology
Emine Duran, Zeynep Ozge Ozturk, Emre Bilgin, Yahya Buyukasik, Omer Dizdar, Gozde Kubra Yardimci, Bayram Farisogullari, Zehra Ozsoy, Gizem Ayan, Gullu Sandal Uzun, Mustafa Ekici, Erdinc Unaldi, Levent Kilic, Ali Akdogan, Omer Karadag, Sule Apras Bilgen, Sedat Kiraz, Umut Kalyoncu, Ali Ihsan Ertenli
Summary: This study aimed to assess the incidence of hematologic malignancy (HM) among inflammatory arthritis (IA) patients receiving tumor necrosis factor inhibitors (TNFi) compared with the general Turkish population. The risk of HMs in inflammatory arthritis patients receiving TNFi was four times higher than in the general Turkish population.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Gozde Kubra Yardimci, Doruk Arslan, Berrin Babaoglu, Ertugrul Cagri Bolek, Levent Kilic, Arzu Saglam, Asli Tuncer, Figen Soylemezoglu, Rahsan Gocmen, Kader K. Oguz, Ersin Tan, Omer Karadag
Summary: In this study, the HUVAC database was used to evaluate cases of pachymeningitis in patients with IgG4-related disease. It was found that most of these patients had normal serum IgG4 levels, therefore not useful for diagnosis. Typical radiology and tentorial thickening should raise suspicion of IgG4-related disease and prompt early biopsy. With steroids+ rituximab treatment, there was no long-term relapse related to meningeal involvement.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Tuba Demirci Yildirim, Asli Kahraman, Aydan Koken Avsar, Fatos Onen, Servet Akar, Ismail Sari
Summary: This study investigated the involvement of the JAK/STAT signaling pathway in the pathogenesis of inflammatory skin diseases (ISDs). The results showed that multiple components of the JAK/STAT pathway were overexpressed in the skin of ISDs patients. These findings suggest that targeting the JAK/STAT pathway could be a potential therapeutic strategy for treating ISDs.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Zehra Ozsoy, Adem Ozdemir, Mustafa Ekici, Emre Bilgin, Levent Kilic, Sedat Kiraz, Zeynep Saribas, Burcin Sener, Omer Karadag
Summary: This study aimed to investigate the effects of immunosuppressive doses on the results of the QuantiFERON-TB Gold Plus (QFT-Plus) test in patients with Rheumatoid Arthritis (RA), as well as the impact of the TB2 tube in the QFT-Plus test. The results showed that higher doses of immunosuppressive drugs in RA patients led to a lower positive rate in the QFT-Plus test, and the addition of the TB2 tube improved the test sensitivity.
RHEUMATOLOGY INTERNATIONAL
(2023)