New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis

Combination of IL-17 and TNFα induces a pro-inflammatory, pro-coagulant and pro-thrombotic phenotype in human endothelial cells

(2012) Arnaud Hot et al.   ANNALS OF THE RHEUMATIC DISEASES

Pathogenesis of spondyloarthritis

(2012) Carmen Ambarus et al.   CURRENT OPINION IN RHEUMATOLOGY

Discovery of the “RNA continent” through a contrarian’s research strategy

(2012) Yoshihide Hayashizaki   GENES & GENETIC SYSTEMS

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

(2012) Zhijie Lin et al.   PLoS One

Identification of low frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization

(2012) Beate Bohm et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis

(2011) Troy Noordenbos et al.   ARTHRITIS AND RHEUMATISM

Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E

(2011) Seon Hee Chang et al.   IMMUNITY

IL-17-induced NF-κB Activation via CIKS/Act1

(2011) Søren Ulrik Sønder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Vertebrate Immunity: Sequence and Functional Analysis of the SEFIR Domain Family Member Act1

(2011) Grigory Ryzhakov et al.   JOURNAL OF MOLECULAR EVOLUTION

IL-17 receptor and its functional significance in psoriatic arthritis

(2011) Siba P. Raychaudhuri et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)

(2011) Dongxu Sun et al.   NATURE IMMUNOLOGY

IL-17R signaling: new players get in on the Act1

(2011) Michael J May   NATURE IMMUNOLOGY

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

(2011) Katarzyna Bulek et al.   NATURE IMMUNOLOGY

IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease

(2011) Jarod Zepp et al.   TRENDS IN IMMUNOLOGY

Role of Th17 cells in human autoimmune arthritis

(2010) Jan Leipe et al.   ARTHRITIS AND RHEUMATISM

Signaling of interleukin-17 family cytokines in immunity and inflammation

(2010) Seon Hee Chang et al.   CELLULAR SIGNALLING

An Atopic Dermatitis-Like Skin Disease with Hyper-IgE-emia Develops in Mice Carrying a Spontaneous Recessive Point Mutation in the Traf3ip2 (Act1/CIKS) Gene

(2010) Y. Matsushima et al.   JOURNAL OF IMMUNOLOGY

The genetics of multiple sclerosis: An update 2010

(2010) Sabine Hoffjan et al.   MOLECULAR AND CELLULAR PROBES

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2

(2010) Eva Ellinghaus et al.   NATURE GENETICS

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

(2010) Ulrike Hüffmeier et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

IL-17F: Regulation, signaling and function in inflammation

(2009) Seon Hee Chang et al.   CYTOKINE

Common and different genetic background for rheumatoid arthritis and coeliac disease

(2009) Marieke J.H. Coenen et al.   HUMAN MOLECULAR GENETICS

Mapping complex disease traits with global gene expression

(2009) William Cookson et al.   NATURE REVIEWS GENETICS

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

(2009) H. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling

(2009) C. Liu et al.   Science Signaling

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides

(2008) Camilla Jandus et al.   ARTHRITIS AND RHEUMATISM

An overview of IL-17 function and signaling

(2008) Sarah L. Gaffen   CYTOKINE

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

TAB4 Stimulates TAK1-TAB1 Phosphorylation and Binds Polyubiquitin to Direct Signaling to NF-κB

(2008) Todd D. Prickett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

(2008) Paul N. Moynagh   TRENDS IN IMMUNOLOGY

Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling

(2007) Xiaoxia Li   CYTOKINE