Article
Biochemistry & Molecular Biology
Kun Qing, Talissa A. Altes, John P. Mugler III, Jaime F. Mata, Nicholas J. Tustison, Kai Ruppert, Juliana Bueno, Lucia Flors, Yun M. Shim, Li Zhao, Joanne Cassani, William G. Teague, John S. Kim, Zhixing Wang, Iulian C. Ruset, F. William Hersman, Borna Mehrad
Summary: The use of hyperpolarized xenon-129 gas as a contrast agent in lung MRI imaging is a promising technique for assessing lung function and detecting impaired lung physiology in UIP patients.
Article
Cardiac & Cardiovascular Systems
Jongmin Lee, Kyuhwan Kim, Yong Suk Jo
Summary: This study compared the prevalence and clinical characteristics of progressive pulmonary fibrosis (PPF) in patients with connective tissue disease (CTD) related interstitial lung disease (ILD) according to different diagnostic criteria. The results showed that the prevalence of PPF varied depending on the diagnostic criteria used, but there was no difference in clinical characteristics.
RESPIRATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Qipan Zhang, Lun Guo, Xuxiang Song, Chengna Lv, Pan Tang, Yan Li, Qunli Ding, Mingcai Li
Summary: The study revealed significantly higher levels of IL-36 alpha and IL-36 gamma in CTD-ILD and IPF patients compared to healthy controls, while IL-36Ra levels did not differ significantly. Increased IL-36 levels were associated with disease severity in IPF patients, with high diagnostic value demonstrated by ROC curve analysis for IL-36 alpha in both IPF and CTD-ILD patients.
CLINICA CHIMICA ACTA
(2022)
Article
Medicine, Research & Experimental
Ju Kwang Lee, Yura Ahn, Han Na Noh, Sang Min Lee, Bin Yoo, Chang-Keun Lee, Yong-Gil Kim, Seokchan Hong, Soo Min Ahn, Ho Cheol Kim
Summary: This study reviewed 197 patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) and found that progressive pulmonary fibrosis (PPF) was significantly associated with mortality, as well as increased rates of respiratory-related hospitalizations, pneumonia, acute exacerbations, and weight loss.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Peter Braubach, Christopher Werlein, Stijn E. Verleden, Isabell Maerzke, Jens Gottlieb, Gregor Warnecke, Sabine Dettmer, Florian Laenger, Danny Jonigk
Summary: This article discusses the range of fibroelastotic changes in pulmonary tissue and proposes stringent histological criteria to distinguish clinically relevant variants. Through systematic evaluation of lung specimens, novel in-transit and activity stages of fibroelastotic remodeling were identified. This comprehensive definition provides a basis for patient stratification and prediction of outcome.
Review
Biochemistry & Molecular Biology
Giuliana Cerro Chiang, Tanyalak Parimon
Summary: CTD-ILD is a group of systemic autoimmune disorders that cause lung interstitial abnormalities or lung fibrosis. The pathogenesis of CTD-ILD is not well understood, but it shares common risk factors with idiopathic pulmonary fibrosis. The primary mechanism involves dysfunction of alveolar type II cells, triggering inflammatory cascades and leading to abnormal lung remodeling and fibrosis. Understanding these mechanisms is important for developing targeted therapies and identifying disease biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joanna G. Escalon, Alan C. Legasto, Dennis Toy, James F. Gruden
Summary: In this study, central paradiaphragmatic middle lobe (ML) involvement was found in most NSIP patients, with high interobserver agreement. Fibrosis was present in nearly all cases, while other features such as subpleural sparing, homogeneity, and bronchiectasis varied among patients.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicol Bernardinello, Elisabetta Cocconcelli, Annalisa Boscolo, Gioele Castelli, Nicolo Sella, Chiara Giraudo, Elisabetta Zanatta, Federico Rea, Marina Saetta, Paolo Navalesi, Paolo Spagnolo, Elisabetta Balestro
Summary: Diaphragm ultrasound can be used to assess diaphragm function in patients with ILD. The prevalence of diaphragmatic dysfunction was 29% in patients with ILD and it was associated with dyspnea. CTD-ILD had lower diaphragm displacement compared to IPF and a higher prevalence of diaphragmatic dysfunction compared to controls.
RESPIRATORY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Roxana-Elena Cirjaliu, Mariana Deacu, Ioana Gherghisan, Angela Stefania Marghescu, Manuela Enciu, Gabriela Izabela Baltatescu, Antonela Anca Nicolau, Doina-Ecaterina Tofolean, Oana Cristina Arghir, Ariadna-Petronela Fildan
Summary: This review provides a comprehensive analysis of the risk factors, clinical, radiologic, and histological features of both post-COVID-19 pulmonary fibrosis (PCPF) and idiopathic pulmonary fibrosis (IPF). It highlights the similarities and differences between these two diseases by gathering relevant articles published in English up until October 2022 using multiple databases. This review aims to assist clinicians, pathologists, and researchers in making accurate diagnoses and selecting patients for anti-fibrotic therapies and future therapeutic perspectives.
Article
Critical Care Medicine
Janelle Vu Pugashetti, Ayodeji Adegunsoye, Zhe Wu, Cathryn T. Lee, Anand Srikrishnan, Sahand Ghodrati, Vivian Vo, Elisabetta A. Renzoni, Athol U. Wells, Christine Kim Garcia, Felix Chua, Chad A. Newton, Philip L. Molyneaux, Justin M. Oldham
Summary: This study found that a decline in FVC of >= 10% and six additional criteria can predict transplant-free survival in patients with non-IPF ILD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Cell Biology
Shengnan Yang, Peipei Liu, Yale Jiang, Zai Wang, Huaping Dai, Chen Wang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, and currently the only medications that can slow down the progression of the disease and improve survival rate are pirfenidone and nintedanib. The use of mesenchymal stem cells (MSCs) provides a new hope for treating interstitial lung disease, but optimal treatment protocols are still lacking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Rheumatology
Natalia Mena-Vazquez, Francisco Gabriel Jimenez-Nunez, Francisco Javier Godoy-Navarrete, Sara Manrique-Arija, Maria Carmen Aguilar-Hurtado, Carmen Maria Romero-Barco, Inmaculada Urena-Garnica, F. Espildora, Maria Isabel Padin-Martin, Antonio Fernandez-Nebro
Summary: The study compared the diagnostic utility of lung ultrasound (US) with high-resolution computed tomography (HRCT) in detecting interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients, finding that lung ultrasound could be a useful tool for ILD diagnosis associated with RA, especially in analyzing specific intercostal spaces for early detection of ILD.
CLINICAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Yu-Hsiang Chiu, Maaike F. M. Koops, Mareye Voortman, H. Wouter van Es, Lucianne C. M. Langezaal, Paco M. J. Welsing, Anna Jamnitski, Anne E. Wind, Jacob M. van Laar, Jan C. Grutters, Julia Spierings
Summary: This study examines the prognostic relevance of different definitions of progressive pulmonary fibrosis (PPF) in patients with CTD-ILD. The results show that higher age, smoking, increased extent of fibrosis, and low baseline DLCO are associated with poor prognosis, while regular pulmonary function evaluation is associated with better survival. The INBUILD, ATS/ERS/JRS/ALAT 2022, and simplified PF criteria have similar prognostic implications in two cohorts.
FRONTIERS IN MEDICINE
(2023)
Article
Respiratory System
Nicholas D. Weatherley, James A. Eaden, Paul J. C. Hughes, Matthew Austin, Laurie Smith, Jody Bray, Helen Marshall, Stephen Renshaw, Stephen M. Bianchi, Jim M. Wild
Summary: The study found correlations between DCE-MRI first pass perfusion and existing physiological gas exchange metrics in IPF patients, suggesting that capillary perfusion deficit may contribute to gas exchange limitation. The FWHMmean metric showed a significant increase over a 6-month period and may serve as a quantitative biomarker for pulmonary vascular disease progression in IPF.
Article
Respiratory System
Kyuhwan Kim, Jongmin Lee, Yong Suk Jo
Summary: This study investigated factors related to the progressive pulmonary fibrosis (PPF) phenotype and found that the use of immunomodulating agents lowered the risk of developing PPF.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Article
Rheumatology
Marika Tardella, Marco Di Carlo, Marina Carotti, Andrea Giovagnoni, Fausto Salaffi
Summary: This study aimed to evaluate the effectiveness and safety of abatacept (ABA) in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The results showed that treatment with ABA was associated with stability or improvement in 88.6% of patients with RA-ILD. Current smoking habit and concomitant methotrexate treatment were modifiable factors associated with worsening of RA-ILD.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Fausto Salaffi, Rossella De Angelis, Sonia Farah, Marina Carotti, Marco Di Carlo
Summary: The study evaluated the impact of frailty on achieving comprehensive disease control (CDC) in rheumatoid arthritis (RA) patients treated with biologic drugs for 12 months. The severity of frailty was found to be related to the achievement of CDC, with higher frailty levels reducing the likelihood of CDC achievement.
CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Marika Tardella, Marco Di Carlo, Marina Carotti, Luca Ceccarelli, Andrea Giovagnoni, Fausto Salaffi
Summary: The study found that treatment with JAKis or ABA was effective in stabilizing or improving RA-ILD in a large percentage of patients, with 83.9% and 88.6% showing stability or improvement, respectively. The duration of RA was the only variable associated with worsening RA-ILD in JAKis-treated patients, while in ABA-treated patients, current smoking habit and concomitant methotrexate treatment were also related to progression of RA-ILD.
INFLAMMOPHARMACOLOGY
(2022)
Article
Immunology
Fausto Salaffi, Marina Carotti, Sonia Farah, Luca Ceccarelli, Andrea Giovagnoni, Marco Di Carlo
Summary: In patients with active rheumatoid arthritis, treatment with JAKis for 4 weeks has a positive effect on central sensitization and pain catastrophizing, leading to improvement in disease activity. There is a correlation between central sensitization, pain catastrophizing, and improvement in disease activity.
INFLAMMOPHARMACOLOGY
(2022)
Editorial Material
Rheumatology
Marco Di Carlo, Fausto Salaffi
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Anesthesiology
Fausto Salaffi, Sonia Farah, Claudia Mariani, Piercarlo Sarzi-Puttini, Marco Di Carlo
Summary: This study aimed to provide further evidence of the convergent and discriminant validity of the Central Sensitization Inventory (CSI) in a large sample of fibromyalgia (FM) patients. Results showed significant correlations between CSI and FM-specific measures, with proposed cutoffs for different disease severity states. The study successfully demonstrated the validity of CSI in FM patients.
Article
Integrative & Complementary Medicine
Marco Di Carlo, Antonio D'Addario, Fausto Salaffi
Summary: Electroacupuncture has demonstrated clinical efficacy in treating opioid-induced hyperalgesia (OIH) and could be a potential treatment option for complex and difficult-to-manage conditions such as OIH.
JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fausto Salaffi, Marina Carotti, Anna Claudia Poliseno, Luca Ceccarelli, Sonia Farah, Marco Di Carlo, Andrea Giovagnoni
Summary: This study aimed to determine the utility of CSA measurements on MRI, at the level of the thigh muscles, in discriminating RA patients with sarcopenia. The results showed that MRI-CSA-25 can differentiate RA patients with sarcopenia from those without.
Article
Allergy
Fausto Salaffi, Andrea Di Matteo, Sonia Farah, Marco Di Carlo
Summary: Frailty is a new concept in rheumatology that can help identify individuals with a higher risk of negative outcomes. It is linked to aging and an increased risk of falls, injuries, and mortality. Inflammation affects immune pathways, multimorbidity, and frailty. Frailty is more common as people age in the community, and various parameters have been validated to identify it.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fausto Salaffi, Marina Carotti, Andrea Di Matteo, Luca Ceccarelli, Sonia Farah, Catalina Villota-Eraso, Marco Di Carlo, Andrea Giovagnoni
Summary: This review summarizes the evidence for using ultrasound and MRI to assess sarcopenia and highlights the advantages of ultrasound in evaluating muscle mass, quality, structure, and biomechanical function.
Article
Radiology, Nuclear Medicine & Medical Imaging
Fausto Salaffi, Marina Carotti, Marco Di Carlo, Luca Ceccarelli, Sonia Farah, Andrea Giovagnoni
Summary: The study focuses on the relationship between joint inflammation and damage of the wrists and hands, functional disability and handgrip strength. The results show that bone edema and synovitis have an influence on the function of the upper extremities. The ultrasound assessment and the magnetic resonance imaging scoring system are useful for semiquantitative assessment of joint inflammation and damage in rheumatoid arthritis (RA).