Journal
ARTHRITIS RESEARCH & THERAPY
Volume 12, Issue 1, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar2928
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Funding
- Wellcome Trust [083650/Z/07/Z, 077092, 079895]
- NIHR Cambridge Biomedical Research Centre
- EU [MEXC-CT-2006-042742]
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The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated systemic vasculitis in genetically susceptible individuals.
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