Article
Rheumatology
Tammo Brunekreef, Maarten Limper, Rowena Melchers, Linda Mathsson-Alm, Jorge Dias, Imo Hoefer, Saskia Haitjema, Jacob M. van Laar, Henny Otten
Summary: This study investigated the potential of 57 new and known autoantibodies for diagnostics or risk stratification in SLE. Anti-dsDNA was found to be the most distinguishing feature between SLE patients and other patients, followed by antibodies against CpG DNA motifs. Anti-CMV antibodies were associated with lupus nephritis in patients with SLE.
LUPUS SCIENCE & MEDICINE
(2021)
Article
Immunology
Cristina Cocco, Elias Manca, Giulia Corda, Maria Maddalena Angioni, Barbara Noli, Mattia Congia, Francesco Loy, Michela Isola, Elisabetta Chessa, Alberto Floris, Lorena Lorefice, Luca Saba, Alessandro Mathieu, Gian Luca Ferri, Alberto Cauli, Matteo Piga
Summary: Brain-reactive autoantibodies are found in patients with SLE and NPSLE, with higher frequency and titers observed in NPSLE patients. The target antigens of these autoantibodies are still undetermined, but they likely include β2GPI.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Viktoryia Laurynenka, Lili Ding, Kenneth M. Kaufman, Judith A. James, John B. Harley
Summary: The association between EBV infection and SLE is reconfirmed, and the presence of anti-EBNA1 antibodies in SLE cases is more frequent than in EBV-infected controls, supporting the hypothesis that anti-EBNA1 contributes to SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
M. Constanza Baroni Pietto, Paola R. Lev, Ana C. Glembotsky, Cecilia P. Marin Oyarzun, Graciela Gomez, Victoria Collado, Cecilia Pisoni, Ramiro A. Gomez, Matias Grodzielski, Jacqueline Gonzalez, Karina Marino, Paula G. Heller, Nora P. Goette, Rosana F. Marta
Summary: The study found that systemic lupus erythematosus (SLE) patients with thrombocytopenia have abnormalities in platelet clearance and production, mainly due to apoptosis and desialylation leading to low platelet count. These abnormalities are more frequently observed in patients with thrombocytopenia and active disease.
Article
Rheumatology
May Yee Choi, Ann Elaine Clarke, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Ken Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, Karen H. Costenbader, Marvin J. Fritzler
Summary: In a longitudinal analysis of a large international incident SLE cohort, three ANA assays demonstrated high positivity rates and commutability. However, over a 5-year follow-up, there was a modest variation in ANA assay performance.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Mary K. Crow
Summary: Research has identified type I interferon (IFN-I) and autoantibodies targeting nucleic acids and nucleic acid-binding proteins as fundamental contributors to the pathogenesis of systemic lupus erythematosus (SLE). This review summarizes recent genetic analyses of SLE patients and current studies on innate and adaptive immune function, which contribute to sustained IFN-I pathway activation, immune activation, autoantibody production, inflammatory mediator generation, and tissue damage. The goal of these studies is to understand disease mechanisms, identify therapeutic targets, and develop better treatments for patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Christina Adamichou, Irini Genitsaridi, Dionysis Nikolopoulos, Myrto Nikoloudaki, Argyro Repa, Alessandra Bortoluzzi, Antonis Fanouriakis, Prodromos Sidiropoulos, Dimitrios T. Boumpas, George K. Bertsias
Summary: A machine learning algorithm was developed to assist in the diagnosis of SLE by analyzing patient data sets, leading to improved diagnostic and treatment outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Julius Lindblom, Lorenzo Beretta, Maria Orietta Borghi, Marta E. Alarcon-Riquelme, Ioannis Parodis
Summary: The study identified CCL8, CXCL13, and IL-1RA as potential serum biomarkers for activity in SLE, correlating with SLE Disease Activity Index 2000 (SLEDAI-2K) scores. Autoantibodies showed similar occurrence across organ domains in SLE patients, with weak correlations to activity in different organ domains.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Qian Wu, Yang Liu, Wei Wang, Yu Zhang, Kui Liu, Song-Hua Chen, Bin Chen
Summary: This meta-analysis investigates the incidence and prevalence of tuberculosis (TB) in patients with systemic lupus erythematosus (SLE). The results show that both the incidence and prevalence of TB are high among SLE patients. Subgroup analyses also reveal that the incidence is higher in Africa and countries with a high TB burden, while the prevalence is elevated in Asia, patients taking a high daily dose of glucocorticoids, studies with small sample sizes and those conducted before 2001.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Rheumatology
Ian Rector, Katherine A. Owen, Prathyusha Bachali, Erika Hubbard, Jinoos Yazdany, Maria Dall'era, Amrie C. Grammer, Peter E. Lipsky
Summary: This study compared the expression of interferon genes between SLE patients of European ancestry and Asian ancestry, and found that patients of Asian ancestry had higher expression, potentially contributing to disease activity.
Article
Immunology
Yingxin Dai, Enling Li, Dandan Chen, Xiangyu Niu, Zhiqing Wang, Liangjing Lu, Bing Zheng
Summary: Monospecific autoantibodies to dense fine speckles 70 (DFS70) antigen are prevalent in Chinese SLE patients and are positively associated with anti-dsDNA. There is consistent dynamic variation between anti-DFS70 and anti-dsDNA during follow-up.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Gabriela Guzman-Martinez, Concepcion Maranon
Summary: Patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD), which is becoming one of the most relevant complications and a significant factor causing morbidity and mortality in SLE. Immune constituents, including specific circulating cell populations, autoantibodies, and inflammatory mediators, play a role in the pathogenesis of atherosclerosis and endothelial damage in SLE patients. This review summarizes the presentation of CVD in SLE, the role of autoimmune responses in inducing atherogenesis, endothelial impairment, and cardiac disease, and discusses the utility of immune mediators as early CVD biomarkers and targets for clinical intervention in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Luis Lucero-Morales, Juanita Romero-Diaz, Diana Yazmin Copado-Mendoza, Maria del Carmen Zamora-Medina, Sandra Acevedo-Gallegos, Juan Manuel Gallardo-Gaona, Berenice Velazquez-Torres, Jose Antonio Ramirez-Calvo, Dulce Maria Camarena-Cabrera, Maria Jose Rodriguez-Sibaja
Summary: The study conducted a diagnostic assessment of pregnant women using a screening questionnaire for SLE, which showed high sensitivity and specificity in diagnosing SLE. The findings suggest that the questionnaire can be a useful tool in determining who requires antinuclear antibody testing and rheumatologist referral for pregnant patients.
LUPUS SCIENCE & MEDICINE
(2021)
Article
Medical Laboratory Technology
Edward K. L. Chan, Carlos A. von Muhlen, Marvin J. Fritzler, Jan Damoiseaux, Maria Infantino, Werner Klotz, Minoru Satoh, Lucile Musset, Ignacio Garcia-De la Torre, Orlando Gabriel Carballo, Manfred Herold, Wilson de Melo Cruvinel, Tsuneyo Mimori, Luis E. C. Andrade
Summary: The establishment of the International Consensus on ANA Patterns (ICAP) was widely welcomed by the medical community and has led to improvements in the classification of HEp-2 IFA patterns. This article summarizes the discussions and current plans from the 6th ICAP Workshop.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Correction
Medical Laboratory Technology
Edward K. L. Chan, Carlos A. von Muhlen, Marvin J. Fritzler, Jan Damoiseaux, Maria Infantino, Werner Klotz, Minoru Satoh, Lucile Musset, Ignacio Garcia-De La Torre, Orlando Gabriel Carballo, Manfred Herold, Wilson de Melo Cruvinel, Tsuneyo Mimori, Karsten Conrad, Luis E. C. Andrade
JOURNAL OF APPLIED LABORATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Andrea Aguilar-Vazquez, Efrain Chavarria-Avila, Mario Salazar-Paramo, Juan Armendariz-Borunda, Guillermo Toriz-Gonzalez, Marcela Rodriguez-Baeza, Ana Sandoval-Rodriguez, Arisbeth Villanueva-Perez, Marisol Godinez-Rubi, Jose-David Medina-Preciado, Ingrid Lundberg, Yesenia Lozano-Torres, Cynthia-Alejandra Gomez-Rios, Oscar Pizano-Martinez, Erika-Aurora Martinez-Garcia, Beatriz-Teresita Martin-Marquez, Sergio Duran-Barragan, Brenda-Lucia Palacios-Zarate, Arcelia Llamas-Garcia, Livier Gomez-Limon, Monica Vazquez-Del Mercado
Summary: This study explored the muscle fiber ultrastructure in Idiopathic Inflammatory Myopathies (IIM), especially in Inclusion Body Myositis, using Scanning Electron Microscopy (SEM) and characterized the immunological profile. Changes in muscle fiber morphology and structure were observed in relation to muscle strength and muscle enzymes.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Esther Guadalupe Corona-Sanchez, Erika Aurora Martinez-Garcia, Andrea Veronica Lujano-Benitez, Oscar Pizano-Martinez, Ivette Alejandra Guerra-Duran, Efrain Chavarria-Avila, Andrea Aguilar-Vazquez, Beatriz Teresita Martin-Marquez, Kevin Javier Arellano-Arteaga, Juan Armendariz-Borunda, Felipe Perez-Vazquez, Ignacio Garcia-De la Torre, Arcelia Llamas-Garcia, Brenda Lucia Palacios-Zarate, Guillermo Toriz-Gonzalez, Monica Vazquez-Del Mercado
Summary: Idiopathic inflammatory myopathies (IIMs) are rare autoimmune diseases characterized by muscle weakness and immune cell invasion into non-necrotic muscle. The presence of myositis-specific antibodies and myositis-associated antibodies is associated with various IIM phenotypes and clinical prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alvaro Cruz, Luis Gerardo Gascon, Claudia Azucena Palafox-Sanchez, Christian Flores-Garcia, Noemi Espinoza-Garcia, Nefertari Sagrero-Fabela, Luciano Tavares Angelo Cintra, Rocio Mejia-Flores, Diana Celeste Salazar-Camarena
Summary: This case-control study aimed to evaluate the association between the TNFSF13B rs9514828 polymorphism and soluble BAFF in apical periodontitis patients. The results showed that the rs9514828 mutation was associated with increased susceptibility to primary AP and decreased risk of secondary AP. It suggests that the TNFSF13B rs9514828 polymorphism may play a role in primary AP susceptibility and that BAFF may be involved in acute and chronic AP.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Medicine, General & Internal
Miguel Marin-Rosales, Claudia Azucena Palafox-Sanchez, Ramon Antonio Franco-Topete, Francisco Josue Carrillo-Ballesteros, Alvaro Cruz, Diana Celeste Salazar-Camarena, Jose Francisco Munoz-Valle, Francisco Ramos-Solano
Summary: This study aimed to evaluate the tissular expression of BAFF in lupus nephritis (LN) and found that BAFF and its receptors are mainly associated with LN class IV, highlighting the role of these receptors as essential pathogenic factors in kidney involvement in SLE patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Oscar Pizano-Martinez, Edgar Mendieta-Condado, Monica Vazquez-Del Mercado, Erika Aurora Martinez-Garcia, Efrain Chavarria-Avila, Daniel Ortuno-Sahagun, Ana Laura Marquez-Aguirre
Summary: Autoimmune rheumatic diseases are a group of heterogeneous disorders characterized by clinical symptoms such as pain, tissue damage, immune deregulation, and inflammation. Biologic disease-modifying antirheumatic drugs are effective treatments, but their complexity can induce the development of anti-drug antibodies. TNF inhibitors, widely used in rheumatoid arthritis, appear to be the main contributors to immunogenicity. This review provides an overview of the immunogenicity of biological agents in autoimmune rheumatic diseases, focusing on the prevalence of anti-drug antibodies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Paula Annahi Menchaca-Tapia, Miguel Marin-Rosales, Diana Celeste Salazar-Camarena, Alvaro Cruz, Edith Oregon-Romero, Raziel Tapia-Llanos, Jose Francisco Munoz-Valle, Claudia Azucena Palafox-Sanchez
Summary: A study on Mexican mestizo subjects found that multiple single-nucleotide polymorphisms (SNPs) in the PTPN22 gene were not associated with susceptibility to primary Sjogren's syndrome (pSS). However, PTPN22 expression may serve as a useful diagnostic biomarker for pSS.
Article
Dentistry, Oral Surgery & Medicine
Claudia Azucena Palafox- Sanchez, Alvaro Cruz, Diana Celeste Salazar-Camarena, Luis Gerardo Gascon, Luciano Tavares Angelo Cintra, Jose Francisco Munoz-Vale, Samuel Garcia-Arelano, Carlos Estrela, Paula Annahi Menchaca-Tapia
Summary: This study investigated the changes in systemic cytokine levels in patients with acute apical abscesses (AAA), and found that patients with AAA had increased serum levels of TNF-a, IL-6, and IL-10. Antibiotic treatment was associated with a decrease in IL-6 and IL-10 levels, while TNF-a levels decreased after antibiotic and endodontic treatment.
JOURNAL OF ENDODONTICS
(2023)
Article
Rheumatology
Nefertari Sagrero-Fabela, Pablo C. Ortiz-Lazareno, Diana C. Salazar-Camarena, Alvaro Cruz, Sergio Cerpa-Cruz, Jose F. Munoz-Valle, Miguel Marin-Rosales, Jhonatan A. Alvarez-Gomez, Claudia A. Palafox-Sanchez
Summary: This study aimed to evaluate the association of cTfh and Tph subpopulations with the BAFF system expression and clinical activity in SLE patients. The results showed that SLE patients had higher percentages of cTfh and Tph cells, which were positively correlated with disease activity. These findings highlight the importance of cTfh and Tph cells in the pathogenesis of SLE.
Article
Rheumatology
Ryan Malcolm Hum, James B. Lilleker, Janine A. Lamb, Alexander G. S. Oldroyd, Guochun Wang, Lucy R. Wedderburn, Louise P. Diederichsen, Jens Schmidt, Maria Giovanna Danieli, Paula Oakley, Zoltan Griger, Thuy Nguyen Thi Phuong, Chanakya Kodishala, Monica Vazquez-Del Mercado, Helena Andersson, Boel De Paepe, Jan L. De Bleecker, Britta Maurer, Liza McCann, Nicolo Pipitone, Neil McHugh, Robert Paul New, William E. Ollier, Niels Steen Krogh, Jiri Vencovsky, Ingrid E. Lundberg, Hector Chinoy
Summary: This study compared the clinical characteristics of adult patients with anti-synthetase syndrome (ASyS) and dermatomyositis (DM), including cutaneous and extramuscular manifestations and malignancy. The results showed that DM-type rashes were frequent in ASyS patients, but there were distinct clinical differences between the two groups. Skin involvement in ASyS did not require increased surveillance for malignancy.
Article
Biochemistry & Molecular Biology
Chairmandurai Aravindraja, Syam Jeepipalli, William Duncan, Krishna Mukesh Vekariya, Sakshee Bahadekar, Edward K. L. Chan, Lakshmyya Kesavalu
Summary: T. forsythia infection results in significant downregulation of miRNA expression in mouse mandibles, which is associated with periodontitis. Some of these downregulated miRNAs have also been detected in gingival tissue and saliva of periodontitis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Luz M. Sanchez-Sanchez, Valentina Martinez-Montoya, Roberto Sandoval-Pacheco, Benjamin Torres-Octavo, Diana M. Anaya-Castro, Ofelia Padilla-de la Torre, Carmen A. Arellano-Valdez, Carmen A. Avila-Rejon, Pedro A. Aguilar-Juarez, Martin Espino-Pluma, Antonio Gonzalez-Santillanes Cruz, Ekaterina Kazakova, Rosa Martinez-Segovia, Dorian Olmos-Morfin, Pablo F. Radillo-Diaz, Ishar Solis-Sanchez, Monica Vazquez Del Mercado-Espinosa, Camilo E. Villarroel-Cortes, Jesus S. Velarde-Felix
Summary: This study describes the genotype and clinical characteristics of Mexican patients with late onset Pompe disease (LOPD). The disease progression is slow, leading to delayed diagnosis. The most common symptoms are axial and proximal muscle weakness, and evaluation of the paraspinal muscles is necessary. The pathogenic mutations found in our patients have been previously reported in genetic databases.
REVISTA DE NEUROLOGIA
(2022)
Article
Biochemistry & Molecular Biology
Jose Antonio Garcia-Espinoza, Jose Francisco Munoz-Valle, Mariel Garcia-Chagollan, Jorge Hernandez-Bello, Claudia Azucena Palafox-Sanchez, Erika Fabiola Lopez-Villalobos, Gabriela Athziri Sanchez-Zuno, Gloria Esther Martinez-Bonilla, Sergio Cerpa-Cruz, Francisco Josue Carrillo-Ballesteros, Edith Oregon-Romero
Summary: This study found that the IVS1 + 173 polymorphism of the ICOS gene is not a genetic marker for the development of pSS, while the c.1624 C>T polymorphism is associated with a reduced risk. Additionally, increased membranal-ICOS expression was observed in pSS patients with high lymphocytic infiltration. These findings suggest that ICOS may play an important role in the pathogenesis of pSS and should be further studied as a possible disease marker in T cell subsets of pSS patients.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Rheumatology
B. -t. Martin-Marquez, F. Sandoval-Garcia, F. -i. Corona-Meraz, M. -h. Petri, Y. -k. Gutierrez-Mercado, M. Vazquez-Del Mercado
Summary: This review highlights the role of osteopontin in systemic lupus erythematosus and neuropsychiatric SLE and discusses the associated immunopathology mechanisms.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)