Review
Immunology
Joel Jihwan Hwang, Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju
Summary: Mesenchymal stem cell (MSC) therapies have shown promising results in treating arthritis by improving joint function, reducing pain, and enhancing quality of life. While some clinical trials have displayed optimistic outcomes, further research is needed to explore their applicability in clinical settings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Juan He, Yu Li, Jian Chen, Qi Wu, Hongying Shan, Xiaocheng Wang, Miaomiao Zhang, Liping Nie, Qingwen Wang
Summary: Different subsets of CD8+ T cells are associated with clinical features and serological parameters in rheumatoid arthritis (RA). Naive CD8+ T cells are negatively correlated with disease activity, while CD8+ CD28-T cells and CD8+ CD27-T cells are positively correlated with disease activity. Activated CD8+ T cells and TCR gamma E+ CD8+ T cells may be involved in inflammation and lipid metabolism in RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Johan Ronnelid, Carl Turesson, Alf Kastbom
Summary: Measurement of autoantibodies like RF and ACPA is crucial in the diagnosis and treatment of RA, but lack of harmonization between different commercial tests poses a challenge. It is recommended that all RF and ACPA tests should have a diagnostic specificity of 98-99%, and the introduction of test result-specific likelihood ratios can provide more precise information for clinical decision-making. Detection of autoantibodies can also be used to predict future arthritis development and prognosis in at-risk patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Rheumatology
Judit Majnik, Gyorgy Nagy
Summary: In addition to joints, rheumatoid arthritis can affect several organs. Coexisting conditions with different pathomechanisms contribute to disease activity, treatment efficacy, mortality, and quality of life. Personalized treatment, considering established comorbidities and contraindications, can lead to better treatment outcomes. Further research can enable assessment of individual risk for future development of comorbidities, based on biomarkers. This biomarker-based person-centred therapy can improve disease control, survival, and quality of life in rheumatoid arthritis.
Article
Rheumatology
Satoshi Takanashi, Yuko Kaneko, Tsutomu Takeuchi
Summary: This study investigated the clinical characteristics of patients with difficult-to-treat RA and the effectiveness of switching to drugs with different modes of action. The results showed that 10.1% of patients were still difficult to treat, and while changing drugs was useful, the proportion of patients achieving remission or low disease activity decreased with each switch.
Review
Rheumatology
Sanggeeta Surandran, Saad Ahmed, Tom Walton, Elena Nikiphorou, Mrinalini Dey
Summary: Early identification and management of multimorbidity in patients with rheumatic and musculoskeletal diseases (RMDs) is critical for disease outcome and treatment response.
Review
Cell Biology
Anqi Zhou, Bingfeng Wu, Hui Yu, Yufei Tang, Jiayi Liu, Yinan Jia, Xiaoyu Yang, Lin Xiang
Summary: This review summarizes the interactions between the skeletal and immune systems, including their co-development and connections at the cellular and molecular levels. Research in osteoimmunology may help uncover the mechanisms of related diseases and provide innovative ideas and solutions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Multidisciplinary Sciences
Fei Dong, Leting Zheng, Weiwei An, Ting Xue, Xiaoning Zhong
Summary: Interstitial lung disease (ILD) is a group of diffuse parenchymal infiltrating diseases. Neutrophil-to-lymphocyte ratio (NLR) is a promising biological marker for ILD's existence, progression, and prognosis. This meta-analysis evaluated the predictive value of elevated NLR levels in ILD. The results showed that ILD patients have higher NLR values and patients with poor prognoses have even higher NLR values, especially in those with connective tissue disease (CTD)-associated ILD. Increased NLR levels are clinically significant for detecting ILD and predicting its poor prognosis, particularly in CTD patients.
Article
Rheumatology
Tariq Aslam, Farrouq Mahmood, Anetha Sabanathan, Robin Waxman, Philip S. Helliwell
Summary: This study compared the clinical and radiographic phenotypes of PsA patients of South Asian and North European origin, finding that South Asian patients tended to have more severe disease and worse impact on their quality of life compared to North European patients.
Article
Rheumatology
Sanjana Tarannum, Jessica Widdifield, C. Fangyun Wu, Sindhu R. Johnson, Paula Rochon, Lihi Eder
Summary: This study compared patterns of healthcare utilization between male and female patients with inflammatory arthritis (IA). The findings showed that female patients had higher healthcare utilization than male patients before and after diagnosis, possibly indicating biological differences in disease course or sociocultural differences in healthcare-seeking behavior.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Physiology
Li Long, Hongmei Guo, Xixi Chen, Yan Liu, Ruyi Wang, Xiaomei Zheng, Xiaobo Huang, Qiao Zhou, Yi Wang
Summary: Rheumatoid arthritis (RA) is a chronic disease characterized by inflammatory synovitis, and ferroptosis may play a role in the pathogenesis and progression of RA. Targeting ferroptosis could be a potential therapeutic approach for treating RA.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Mona Maddahi, Elyas Nattagh-Eshtivani, Mohammadhassan Jokar, Mehdi Barati, Hamed Tabesh, Mohammad Safarian, Maryam Khosravi
Summary: This study aimed to evaluate the effects of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis. The results of a randomized, double-blind, placebo-controlled clinical trial showed that propolis supplementation significantly reduced cardiovascular risk factors and could be a promising treatment strategy for cardiovascular complications among rheumatoid arthritis patients.
PHYTOTHERAPY RESEARCH
(2023)