Article
Immunology
Iris Paola Guzman-Guzman, Claudia Isabel Ramirez-Velez, Ramces Falfan-Valencia, Jose Eduardo Navarro-Zarza, Ilse Adriana Gutierrez-Perez, Oscar Zaragoza-Garcia, Monica Ramirez, Natividad Castro-Alarcon, Isela Parra-Rojas
Summary: The SNP of the PADI2 gene plays a crucial role in the pathogenesis and severity of rheumatoid arthritis (RA), with specific genotypes in women from southern Mexico being associated with early disease onset, positive autoantibodies, and radiographic joint damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Signe Moller-Bisgaard, Stylianos Georgiadis, Kim Horslev-Petersen, Bo Ejbjerg, Merete Lund Hetland, Lykke Midtboll Ornbjerg, Daniel Glinatsi, Jakob Moller, Mikael Boesen, Kristian Stengaard-Pedersen, Ole Rintek Madsen, Bente Jensen, Jan Alexander Villadsen, Ellen-Margrethe Hauge, Philip Bennett, Oliver Hendricks, Karsten Asmussen, Marcin Kowalski, Hanne Lindegaard, Henning Bliddal, Niels Steen Krogh, Torkell Ellingsen, Agnete H. Nielsen, Lone Balding, Anne Grethe Jurik, Henrik S. Thomsen, Mikkel Ostergaard
Summary: The study identified baseline MRI osteitis and tenosynovitis as independent predictors of 2-year MRI damage progression in RA patients in clinical remission. Age and gender were predictors of radiographic damage progression. Following an MRI treat-to-target strategy predicted achievement of stringent remission.
Article
Rheumatology
Doortje Krijbolder, Fenne Wouters, Elise van Mulligen, Annette H. M. Van der Helm-van Mil
Summary: In patients with clinically suspect arthralgia, morning stiffness is associated with subclinical joint inflammation, providing a better understanding of its importance for evaluating joint pain in clinical practice.
Article
Rheumatology
Xanthe M. E. Matthijssen, Ellis Niemantsverdriet, Saskia Le Cessie, Annette H. M. Van der Helm-van Mil
Summary: This study found that the decrease of inflammatory features usually occurs simultaneously in patients with RA and undifferentiated arthritis, including in ACPA subgroups, but synovitis decrease typically precedes tenosynovitis decrease. Additionally, in ACPA-positive patients, synovitis decrease occurs before osteitis decrease.
Article
Rheumatology
Sascha L. Heckert, Sytske Anne Bergstra, Xanthe M. E. Matthijssen, Yvonne P. M. Goekoop-Ruiterman, Faouzia Fodili, Saskia Ten Wolde, Cornelia F. Allaart, Tom W. J. Huizinga
Summary: In patients with rheumatoid arthritis, baseline joint swelling was significantly associated with swelling in the same joint during follow-up, and it was found to better predict local joint swelling compared to baseline swelling in other joints. This suggests that local factors play a role in the recurrence of joint swelling over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Navkiran Sidhu, Fenne Wouters, Ellis Niemantsverdriet, Annette H. M. Van der Helm-van Mil
Summary: This study investigated the clinical and serological features associated with the development of rheumatoid arthritis (RA) in patients with undifferentiated large joint arthritis. The findings revealed that autoantibody positivity and subclinical synovitis were independent predictors of RA development. Additionally, MRI detection of synovitis improved diagnostic accuracy.
Article
Rheumatology
Dominik Deppe, Kay-Geert Hermann, Fabian Proft, Denis Poddubnyy, Felix Radny, Mikhail Protopopov, Marcus R. Makowski, Torsten Diekhoff
Summary: In patients with axSpA, SWI depicts erosions and sclerosis more accurately than T1 spin echo MRI at 1.5T.
Article
Medicine, General & Internal
Takahiro Mizuuchi, Tetsuji Sawada, Susumu Nishiyama, Koichiro Tahara, Haeru Hayashi, Hiroaki Mori, Eri Kato, Mayu Tago, Toshihiro Matsui, Shigeto Tohma
Summary: The involvement of distal interphalangeal (DIP) joints in adult-onset rheumatoid arthritis (RA) is associated with disease activity, particularly affecting small-sized and upper-extremity joints.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Automation & Control Systems
Hongyang Li, Yuanfang Guan
Summary: In this study, a method that seamlessly integrates deep learning and traditional machine learning models is presented to study multiple images and score joint damages in rheumatoid arthritis. This method allows the quantification of joining space narrowing and reveals the crossregulation map of joint damages in rheumatoid arthritis.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Article
Rheumatology
Christian Dejaco, Pedro M. Machado, Francesco Carubbi, Philipp Bosch, Lene Terslev, Giorgio Tamborrini, Luca Maria Sconfienza, Carlo Alberto Scire, Sebastian Ruetten, Jef van Rompay, Fabian Proft, Costantino Pitzalis, Marina Obradov, Rikke Helene Moe, Vasco V. Mascarenhas, Clara Malattia, Andrea Sabine Klauser, Alison Kent, Lennart Jans, Wolfgang Hartung, Hilde Berner Hammer, Christina Duftner, Peter Balint, Alessia Alunno, Xenofon Baraliakos
Summary: This study developed evidence-based Points to Consider (PtC) for the use of imaging modalities to guide interventional procedures in patients with rheumatologic and musculoskeletal diseases. Recommendations included preference for imaging over palpation to guide targeted interventions at peripheral joints, periarticular musculoskeletal structures, nerves and the spine, with ultrasound as the favored imaging technique for peripheral joints and nerves.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Margaret H. Chang, Alexandra Bocharnikov, Siobhan M. Case, Marc Todd, Jessica Laird-Gion, Maura Alvarez-Baumgartner, Peter A. Nigrovic
Summary: This study aims to identify patient-specific patterns of joint flare in inflammatory arthritides to distinguish local from systemic drivers of disease chronicity. The results showed that arthritis flares preferentially affect previously inflamed joints and carry an ongoing risk of disease extension. These findings confirm joint-specific memory and suggest that prevention of new joint accumulation should be an important target for arthritis therapy.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Pharmacology & Pharmacy
Ayda Henriques Schneider, Thaise Mayumi Taira, Gabriel Azevedo Publio, Douglas da Silva Prado, Paula Barbim Donate Yabuta, Jessica Cristina dos Santos, Caio Cavalcante Machado, Flavio Falcao Lima de Souza, Lucas Gabriel Rodrigues Venturini, Rene Donizeti Ribeiro de Oliveira, Thiago Mattar Cunha, Jose Carlos Alves-Filho, Paulo Louzada-Junior, Tarcilia Aparecida da Silva, Sandra Yasuyo Fukada, Fernando Queiroz Cunha
Summary: The study found that patients with rheumatoid arthritis had higher levels of NETs in synovial fluid, and inhibiting NETs could be a potential strategy to reduce bone erosion in arthritis patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Frank Piva, Philippe Gervois, Youness Karrout, Famara Sane, Marie-Benedicte Romond
Summary: This study investigates the protective potential of Bifidobacterium longum cell wall lipoproteins (Lpps) in rheumatoid arthritis (RA) and finds that they can modulate the gut microbiota and alleviate arthritis symptoms. The dosage of Lpps is critical for preventing arthritis progression and appropriately modulating the microbiome. The results also suggest that Lpps may trigger the immune system.
Article
Health Care Sciences & Services
Eun-Jung Park, WooSeong Jeong, Jinseok Kim
Summary: This study aimed to evaluate radiographic outcome and prognostic factors for radiographic progression in patients with seronegative rheumatoid arthritis. It found that radiographic damage and SvdH at diagnosis were predictive factors for progression of radiographic damage in these patients, highlighting the importance of early detection and management strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
