Journal
ARTHRITIS RESEARCH & THERAPY
Volume 10, Issue 5, Pages -Publisher
BMC
DOI: 10.1186/ar2481
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Funding
- Arthritis Research Campaign
- Trustees of the Kennedy Institute of Rheumatology
- National Institutes of Health
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Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the population and leading to the destruction of the joints. Evidence exists for the involvement of the innate as well as the adaptive immune systems in the pathology of the disease. The success of anti-tumour necrosis factor-alpha indicates the importance of pro-inflammatory mediators produced by innate immune cells in rheumatoid arthritis progression. Therefore, considerable efforts have been made in elucidating the signalling pathways leading to the expression of those mediators. This review will concentrate on the role of signalling pathways in innate immune cells in the context of rheumatoid arthritis.
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