Review
Medicine, General & Internal
Sammy Badr, Thibaut Jacques, Guillaume Lefebvre, Youssef Boulil, Ralph Abou Diwan, Anne Cotten
Summary: MRI examination of the sacroiliac joints is helpful in identifying early axial spondyloarthritis, but it is important to recognize the potential differential diagnoses that can mimic inflammatory sacroiliitis in clinical practice.
Editorial Material
Rheumatology
Denis Poddubnyy, Torsten Diekhoff, Xenofon Baraliakos, Kay Geert A. Hermann, Joachim Sieper
Summary: This article discusses whether MRI can replace radiographs for diagnostic evaluation and classification of axial spondyloarthritis, and provides answers to specific questions based on current data.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Walter P. Maksymowych, Robert G. Lambert, Xenofon Baraliakos, Ulrich Weber, Pedro M. Machado, Susanne J. Pedersen, Manouk de Hooge, Joachim Sieper, Stephanie Wichuk, Denis Poddubnyy, Martin Rudwaleit, Desiree van der Heijde, Robert Landewe, Iris Eshed, Mikkel Ostergaard
Summary: This study aimed to determine quantitative cut-offs for SI joint MRI lesions typical of inflammatory and structural lesions in axSpA, which can predict clinical diagnosis. The results showed that cut-offs for MRI findings specific to axSpA had PPVs greater than or equal to 95% for clinical diagnosis. Thus, the proposed cut-offs can be used for disease classification and clinical research to improve the diagnostic accuracy for axSpA.
Article
Biology
Anca Emanuela Musetescu, Anca Bobirca, Florin Liviu Gherghina, Alesandra Florescu, Florin Bobirca, Paulina Lucia Ciurea, Cristina Criveanu, Alice Musca, Lucian Mihai Florescu, Ioana Andreea Gheonea
Summary: This study aimed to assess the performance of rheumatologists in interpreting inflammatory and structural damage to sacroiliac joints in axSpA patients, compared to radiologists. The results showed substantial agreement between senior and junior radiologists, as well as between senior radiologists and senior rheumatologists, while moderate agreement was observed with junior rheumatologists.
Article
Rheumatology
Walter P. Maksymowych, Mikkel Ostergaard, Robert Landewe, William Barchuk, Ke Liu, Chantal Tasset, Leen Gilles, Thijs Hendrikx, Robin Besuyen, Xenofon Baraliakos
Summary: The study found that filgotinib significantly reduced SI joint erosion and increased backfill scores in AS patients, suggesting potential prognostic implications for ankylosis development.
Article
Rheumatology
Alexandre Sepriano, Sofia Ramiro, Robert Landewe, Anna Molto, Pascal Claudepierre, Daniel Wendling, Maxime Dougados, Desiree van der Heijde
Summary: The study found a predictive and longitudinal association between inflammation detected on MRI and several types of structural damage detected on MRI in patients with early axial SpA, which adds to the evidence for a causal relationship.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Medicine, General & Internal
Churong Lin, Dong Liu, Budian Liu, Jieruo Gu
Summary: This study investigated the distribution pattern of acute and chronic lesions in the sacroiliac joints (SIJ) of patients with axial spondyloarthritis (axSpA). The results showed that there was no specific distribution pattern of these lesions in different SIJ sections, except for a higher occurrence rate of erosions in the iliac sections.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Immunology
Dong Liu, Churong Lin, Budian Liu, Jun Qi, Huiquan Wen, Liudan Tu, Qiujing Wei, Qingcong Kong, Ya Xie, Jieruo Gu
Summary: Chemical shift-encoded MRI (CSE-MRI) is a reliable tool to assess the fat metaplasia in the SIJs of axSpA patients. Extensive fat deposition in the SIJs adds incremental diagnostic value to bone marrow edema (BME), but at the cost of decreased specificities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gehad A. Saleh, Ali H. Elmokadem, Ahmed Abdel Razek, Ahmed El-Morsy, Omar Hamdy, Elshimaa S. Eleraky, Marwa Saleh
Summary: This study assessed the diagnostic accuracy of diffusion tensor imaging (DTI) in hepatic focal lesions (HFLs) and compared it to diffusion-weighted imaging (DWI). The results showed that MD and FA of DTI are excellent discriminators, superior to ADC measured by DWI, for differentiating malignant and benign HFLs.
EUROPEAN RADIOLOGY
(2023)
Article
Rheumatology
Sevtap Tugce Ulas, Fabian Proft, Torsten Diekhoff, Valeria Rios Rodriguez, Judith Rademacher, Denis Poddubnyy, Katharina Ziegeler
Summary: HLA-B27 status does not significantly influence the occurrence and extent of SIJ lesions in patients with low back pain of non-inflammatory origin, regardless of gender.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michel D. Crema, Anne Miquel, Arnaud Gouvion, Catherine Phan, Ling Li, Yves Menu, Lionel Arrive
Summary: The diagnostic performance of MRI in detecting erosions in the sacroiliac joints is significantly improved when using T1w images with fat suppression compared to images without fat suppression.
EUROPEAN RADIOLOGY
(2021)
Review
Rheumatology
Juergen Braun, Uta Kiltz, Xenofon Baraliakos
Summary: Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease primarily affecting the axial skeleton, with treatments aimed at reducing new bone formation to slow disease progression.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elke Vereecke, Lieve Morbee, Frederiek Laloo, Min Chen, Jacob L. L. Jaremko, Nele Herregods, Lennart Jans
Summary: This study analyzed the prevalence of anatomical variants of sacroiliac joints (SIJ) using sCT images in 215 patients suspected of sacroiliitis. Over 80% of the evaluated joints had SIJ variants, with the most common being iliosacral complex, bipartite iliac bony plate, and crescent iliac bony plate. The occurrence of these variants was associated with age, sex, and body weight, with iliosacral complex being more frequent in men and associated with higher BMI.
INSIGHTS INTO IMAGING
(2023)
Article
Rheumatology
Xenofon Baraliakos, Anna Kuehn, Styliani Tsiami, Uta Kiltz, Martin Fruth, Juergen Braun
Summary: Age has different influences on the MRI lesions in the sacroiliac joints of patients with and without axial spondyloarthritis (axSpA). Bone marrow edema (BME) and erosions are more frequent in axSpA patients regardless of age, while fat lesions (FL) are only significantly different in patients over 50 years old.
Article
Rheumatology
Sengul Seven, Mikkel Ostergaard, Lone Morsel-Carlsen, Inge Juul Sorensen, Birthe Bonde, Gorm Thamsborg, Jens Jorgen Lykkegaard, Susanne Juhl Pedersen
Summary: The study found that a FAT depth greater than 5 mm can almost differentiate patients with axial spondyloarthritis (axSpA) from other groups. When excluding post-partum women, a BME greater than 5 mm and erosion were highly specific for axSpA.
Letter
Rheumatology
Walter P. Maksymowych, Robert G. W. Lambert, Mikkel ostergaard, Xenofon Baraliakos
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Desiree van der Heijde, Mikkel Ostergaard, John D. Reveille, Xenofon Baraliakos, Andris Kronbergs, David M. Sandoval, Xiaoqi Li, Hilde Carlier, David H. Adams, Walter P. Maksymowych
Summary: This study evaluates the long-term effect of IXE on radiographic changes in the spine in patients with r-axSpA and identifies potential predictors of progression. The majority of patients had no radiographic progression in the spine through 2 years of treatment.
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Rheumatology
Iain B. McInnes, Zoltan Szekanecz, Dennis McGonagle, Walter P. Maksymowych, Alexander Pfeil, Ralph Lippe, In-Ho Song, Apinya Lertratanakul, Thierry Sornasse, Ana Biljan, Atul Deodhar
Summary: Spondyloarthritis (SpA) is a group of chronic inflammatory diseases characterized by overlapping clinical, genetic and pathophysiological features. Various cytokines are involved in the pathogenesis of SpA, and inhibition of the JAK signaling pathway can suppress SpA development. This article discusses the role of JAK signaling in the pathogenesis of SpA and summarizes the safety and efficacy of JAK inhibition based on relevant clinical trials.
Article
Rheumatology
Walter P. Maksymowych, Mikkel Ostergaard, Robert Landewe, William Barchuk, Ke Liu, Leen Gilles, Thijs Hendrikx, Robin Besuyen, Xenofon Baraliakos
Summary: The study showed that filgotinib treatment was associated with significant reductions in spinal inflammation, suggesting potential therapeutic benefits for patients with active ankylosing spondylitis.
Article
Rheumatology
Xenofon Baraliakos, Mikkel Ostergaard, Robert G. W. Lambert, Iris Eshed, Pedro M. Machado, Susanne Juhl Pedersen, Ulrich Weber, Manouk de Hooge, Joachim Sieper, Denis Poddubnyy, Martin Rudwaleit, Desiree van der Heijde, Robert B. M. Landewe, Walter Maksymowych
Summary: This study updated and validated the definitions of spinal MRI lesions associated with axial spondyloarthritis (axSpA), focusing on inflammatory and structural lesions in terms of localization, extension, and extent, with new classifications based on lesion maturity. The reliability assessment confirmed VC fat lesion and VC monomorphic inflammatory lesion as the most reliably assessed lesions.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Walter P. Maksymowych, Mikkel Ostergaard
Summary: There is a renewed interest in defining the axial inflammation component of Psoriatic Arthritis (PsA), as recent studies suggest that this entity may respond differently to treatment compared to patients with axial spondyloarthritis. A workshop was conducted to review the literature on diagnosing PsA and to determine the most appropriate criteria. It was widely agreed that magnetic resonance imaging (MRI) plays an important role in defining axial inflammation in PsA, and it would be ideal to establish optimal MRI quantitative cut-offs for lesions in the sacroiliac joints and/or spine that reflect imaging typical of axial inflammation in PsA.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Walter P. Maksymowych, Robert G. W. Lambert, Liron Caplan, Filip E. van den Bosch, Mikkel ostergaard
Summary: The current RCT design does not fully utilize MRI to select nr-axSpA patients who best demonstrate differences in clinical response rates between active drug and placebo therapies. Future studies should incorporate revised patient inclusion criteria based on expanded MRI evaluation and data-driven definitions of a positive MRI to improve discrimination between therapies.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Rheumatology
Desiree van der Heijde, Lianne S. Gensler, Walter P. Maksymowych, Robert Landewe, Martin Rudwaleit, Lars Bauer, Thomas Kumke, Mindy Kim, Simone Emanuele Auteri, Bengt Hoepken, Atul Deodhar
Summary: The 52-week results from the C-axSpAnd study demonstrate the long-term safety and efficacy of Certolizumab pegol (CZP) in patients with active non-radiographic axial spondyloarthritis (nr-axSpA). CZP treatment for up to 3 years is well tolerated and leads to sustained clinical improvement.
Article
Rheumatology
Victoria Navarro-Compan, Anne Boel, Annelies Boonen, Philip J. Mease, Maxime Dougados, Uta Kiltz, Robert B. M. Landewe, Xenofon Baraliakos, Wilson Bautista-Molano, Praveena Chiowchanwisawakit, Hanne Dagfinrud, Lara Fallon, Marco Garrido-Cumbrera, Lianne Gensler, Bassel Kamal ElZorkany, Nigil Haroon, Yu Heng Kwan, Pedro M. Machado, Walter Maksymowych, Anna Molto, Natasha de Peyrecave, Denis Poddubnyy, Mikhail Protopopov, Sofia Ramiro, In-Ho Song, Salima van Weely, Desiree van der Heijde
Summary: This study aims to define the instruments for the Assessment of SpondyloArthritis international Society-Outcomes Measures in Rheumatology core domain set for axial spondyloarthritis (axSpA). The study selected core outcome instruments through a systematic literature review and assessment of the instruments' psychometric properties. Additionally, the study endorsed additional instruments to enhance the evaluation of axSpA trials.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Mikhail Protopopov, Fabian Proft, Stephanie Wichuk, Pedro M. Machado, Robert G. Lambert, Ulrich Weber, Susanne Juhl Pedersen, Mikkel Ostergaard, Joachim Sieper, Martin Rudwaleit, Xenofon Baraliakos, Walter P. Maksymowych, Denis Poddubnyy
Summary: This study compares the ability of MRI and conventional radiography to detect structural lesions indicative of axSpA.
Review
Rheumatology
Ying-Ying Leung, Tatiana V. Korotaeva, Liliana Candia, Susanne Juhl Pedersen, Wilson Bautista Molano, Eric M. Ruderman, Radjesh Bisoendial, Rodolfo Perez-Alamino, Wendy Olsder, Burkhard Moeller, Simeon Grazio, Tania Gudu, Girish M. Mody, Carlos Pineda, Helena Raffayova, Sherry Rohekar, Claudia Goldenstein-Schainberg, Sergio R. Gutierrez Urena, Julio Cesar Casasola Vargas, Bhowmik Meghnathi, Roopa Prasad, Pascal Richette, Jose Roberto S. Miranda, Nikolas Malliotis, Ulla Lindqvist, David Simon, Amara Ezeonyeli, Enrique R. Soriano, Oliver FitzGerald
Summary: The objective of this study was to provide evidence for the efficacy and safety of therapeutic options for the peripheral arthritis domain of PsA for the revised 2021 GRAPPA treatment recommendations. Evidence was derived from new RCTs and recommendations were made for different patient groups based on their treatment history and response. Different classes of therapeutic options were strongly recommended for different patient groups.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Helena Port, Signe Holm Nielsen, Peder Frederiksen, Sofie Falkenlove Madsen, Anne-Christine Bay-Jensen, Inge Juul Sorensen, Bente Jensen, Anne Gitte Loft, Ole Rintek Madsen, Mikkel Ostergaard, Susanne Juhl Pedersen
Summary: This study investigated whether extracellular matrix (ECM) blood-based biomarkers reflect the pharmacodynamic effect and response to TNF-a inhibitor therapy in patients with axial spondyloarthritis (axSpA). The results showed that ECM metabolites exhibited a pharmacodynamic effect and were associated with ASDAS response.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Walter P. Maksymowych, Jacob L. Jaremko, Susanne J. Pedersen, Iris Eshed, Ulrich Weber, Andrew McReynolds, Paul Bird, Stephanie Wichuk, Robert G. Lambert
Summary: This study compared the performance of two new web-based MRI scoring systems (KIMRISS and MOAKS) in quantification of bone marrow lesions (BML) and synovitis-effusion (S-E). The results showed that KIMRISS had higher reliability and usability in evaluating BML and synovitis. Both methods should be further compared in clinical trials of new therapies for OA.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Rheumatology
Signe Holm Nielsen, Shu Sun, Anne C. Bay-Jensen, Morten Karsdal, Inge Juul Sorensen, Ulrich Weber, Anne Gitte Loft, Gina Kollerup, Gorm Thamsborg, Ole Rintek Madsen, Jakob Moller, Mikkel Ostergaard, Susanne Juhl Pedersen
Summary: This study investigated the association of extracellular matrix (ECM) metabolites with treatment response in axSpA patients receiving TNF-alpha inhibitory therapy. The results showed that certain ECM metabolites were associated with ASDAS response, MRI inflammation, and clinical treatment response.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Rheumatology
Helena Port, Signe Holm Nielsen, Sofie Falkenlove Madsen, Anne-Christine Bay-Jensen, Morten Karsdal, Sengul Seven, Inge Juul Sorensen, Lone Morsel-Carlsen, Mikkel Ostergaard, Susanne Juhl Pedersen
Summary: This study investigated circulating biomarkers of extracellular matrix (ECM) remodeling and inflammation as potential markers to identify patients with axial spondyloarthritis (axSpA). The results showed that axSpA patients had altered turnover of type I, IV, and VI collagens compared to non-axSpA control groups. The biomarker PRO-C4 was found to be the best indicator for differentiating axSpA patients from non-axSpA subjects.
ARTHRITIS RESEARCH & THERAPY
(2022)