Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis

Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells

(2018) Yinan Nan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenomics

(2018) Kevin C. Wang et al.   CIRCULATION RESEARCH

The aliens inside us: HERV-W endogenous retroviruses and multiple sclerosis

(2018) Antonina Dolei   Multiple Sclerosis Journal

Human Endogenous Retroviruses in Neurological Diseases

(2018) Patrick Küry et al.   TRENDS IN MOLECULAR MEDICINE

Elevated HERV-K Expression in Soft Tissue Sarcoma Is Associated with Worsened Relapse-Free Survival

(2018) Maria Giebler et al.   Frontiers in Microbiology

The aliens inside us: HERV-W endogenous retroviruses and multiple sclerosis

(2018) Antonina Dolei   Multiple Sclerosis Journal

Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases

(2017) Geoffrey L. Rogers et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

miR-30c suppresses prostate cancer survival by targeting the ASF/SF2 splicing factor oncoprotein

(2017) Ya-Qiang Huang et al.   Molecular Medicine Reports

Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases

(2017) Thomas Kocher et al.   MOLECULAR THERAPY

Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci

(2017) Samuel Lessard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma

(2017) Tzu-Wei Lin et al.   Oncotarget

A human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion

(2017) Cécile Lemaître et al.   PLoS Pathogens

TDP-43 regulates cancer-associated microRNAs

(2017) Xiaowei Chen et al.   Protein & Cell

The Therapeutic Potential of CRISPR/Cas9 Systems in Oncogene-Addicted Cancer Types: Virally Driven Cancers as a Model System

(2017) Luqman Jubair et al.   Molecular Therapy-Nucleic Acids

Identification of TDP-43 as an oncogene in melanoma and its function during melanoma pathogenesis

(2016) Qinghai Zeng et al.   CANCER BIOLOGY & THERAPY

High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients

(2016) Patrick Y. Kim et al.   CANCER LETTERS

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

(2016) R Kaminski et al.   GENE THERAPY

JC polyomavirus expression and bell-shaped regulation of its SF2/ASF suppressor during the follow-up of multiple sclerosis patients treated with natalizumab

(2016) Elena Uleri et al.   JOURNAL OF NEUROVIROLOGY

CRISPR gene-editing tested in a person for the first time

(2016) David Cyranoski   NATURE

ALS: A bucket of genes, environment, metabolism and unknown ingredients

(2016) Mónica Zufiría et al.   PROGRESS IN NEUROBIOLOGY

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells

(2016) Fuling Zhou et al.   Oncotarget

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies

(2016) Lin Guo et al.   Cold Spring Harbor Perspectives in Medicine

Human Endogenous Retroviruses-K (HML-2) Expression Is Correlated with Prognosis and Progress of Hepatocellular Carcinoma

(2016) Weijie Ma et al.   Biomed Research International

Human endogenous retroviruses and cancer

(2016) Gonzalez-Cao María et al.   Cancer Biology & Medicine

Regulation of MALAT1 expression by TDP43 controls the migration and invasion of non-small cell lung cancer cells in vitro

(2015) Fengjie Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIV-1 splicing is controlled by local RNA structure and binding of splicing regulatory proteins at the major 5′ splice site

(2015) Nancy Mueller et al.   JOURNAL OF GENERAL VIROLOGY

Splicing factor 2/alternative splicing factor contributes to extracellular signal-regulated kinase activation in hepatocellular carcinoma cells

(2015) YAWEI ZHAO et al.   Molecular Medicine Reports

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Human endogenous retrovirus HERV-K(HML-2) activity in prostate cancer is dominated by a few loci

(2015) Wolfgang Goering et al.   PROSTATE

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

HERV-K(HML-2) rec and np9 transcripts not restricted to disease but present in many normal human tissues

(2015) Katja Schmitt et al.   Mobile DNA

HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll-like receptor 4

(2014) Elena Uleri et al.   AIDS

MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF

(2014) Junqing Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Cytotoxicity of Human Endogenous Retrovirus K-Specific T Cells toward Autologous Ovarian Cancer Cells

(2014) K. Rycaj et al.   CLINICAL CANCER RESEARCH

Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?

(2014) Ronan F. Downey et al.   INTERNATIONAL JOURNAL OF CANCER

HIV-1 Infection Leads to Increased Transcription of Human Endogenous Retrovirus HERV-K (HML-2) Proviruses In Vivo but Not to Increased Virion Production

(2014) N. Bhardwaj et al.   JOURNAL OF VIROLOGY

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The translational landscape of the splicing factor SRSF1 and its role in mitosis

(2014) Magdalena M Maslon et al.   eLife

RRM1 domain of the splicing oncoprotein SRSF1 is required for MEK1-MAPK-ERK activation and cellular transformation

(2013) Ariel Shimoni-Sebag et al.   CARCINOGENESIS

The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells

(2013) T Chen et al.   LEUKEMIA

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells

(2013) M F Kendellen et al.   ONCOGENE

Mechanisms of the androgen receptor splicing in prostate cancer cells

(2013) L L Liu et al.   ONCOGENE

HnRNP A1/A2 and SF2/ASF Regulate Alternative Splicing of Interferon Regulatory Factor-3 and Affect Immunomodulatory Functions in Human Non-Small Cell Lung Cancer Cells

(2013) Rong Guo et al.   PLoS One

Human Endogenous Retrovirus Protein Activates Innate Immunity and Promotes Experimental Allergic Encephalomyelitis in Mice

(2013) Hervé Perron et al.   PLoS One

HERV-K and LINE-1 DNA Methylation and Reexpression in Urothelial Carcinoma

(2013) Ulrike Kreimer et al.   Frontiers in Oncology

Detection of Human Endogenous Retrovirus K (HERV-K) Transcripts in Human Prostate Cancer Cell Lines

(2013) Lorenzo Agoni et al.   Frontiers in Oncology

Role of epidermal growth factor receptor in breast cancer

(2012) Hiroko Masuda et al.   BREAST CANCER RESEARCH AND TREATMENT

Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia

(2012) Limin Zou et al.   Journal of Hematology & Oncology

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

(2012) Olga Anczuków et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ENCODE Project Writes Eulogy for Junk DNA

(2012) E. Pennisi   SCIENCE

Selective changes of retroelement expression in human prostate cancer

(2011) Wolfgang Goering et al.   CARCINOGENESIS

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

(2011) Lionel M. Igaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals

(2011) R. Contreras-Galindo et al.   JOURNAL OF VIROLOGY

Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

(2011) Ravi P Subramanian et al.   Retrovirology

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

Identification of ASF/SF2 as a Critical, Allele-Specific Effector of the Cyclin D1b Oncogene

(2010) N. A. Olshavsky et al.   CANCER RESEARCH

Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor

(2010) S. Kaufmann et al.   JOURNAL OF GENERAL VIROLOGY

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control

(2010) Shuying Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Reverse Transcription Inhibitor Abacavir Shows Anticancer Activity in Prostate Cancer Cell Lines

(2010) Francesca Carlini et al.   PLoS One

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

(2010) Hans Wils et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel reliable real-time PCR for differential detection of MSRVenv and syncytin-1 in RNA and DNA from patients with multiple sclerosis

(2009) Giuseppe Mameli et al.   JOURNAL OF VIROLOGICAL METHODS

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

(2009)   MICROBIOLOGY-SGM

Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone

(2009) J.P. Michiel Sedelaar et al.   PROSTATE