RNA Virus Reverse Genetics and Vaccine Design

Calling for rapid development of a safe and effective MERS vaccine

(2014) Peter J. Hotez et al.   MICROBES AND INFECTION

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

Population Structure and Evolution of Rhinoviruses

(2014) Vaishali P. Waman et al.   PLoS One

Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution

(2014) X.-C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available

(2014) Tomohiro Ishikawa et al.   VACCINE

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines

(2014) Cuiqing Ma et al.   VACCINE

The yellow fever 17D virus as a platform for new live attenuated vaccines

(2014) Myrna C Bonaldo et al.   Human Vaccines & Immunotherapeutics

Recombinant Trivalent Influenza Vaccine (Flublok®): A Review of Its Use in the Prevention of Seasonal Influenza in Adults

(2013) Lily P. H. Yang   DRUGS

Polypyrimidine Tract Binding Protein-1 (PTB1) Is a Determinant of the Tissue and Host Tropism of a Human Rhinovirus/Poliovirus Chimera PV1(RIPO)

(2013) Nusrat Jahan et al.   PLoS One

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

(2013) T. Scobey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Surprising New Dengue Virus Throws a Spanner in Disease Control Efforts

(2013) D. Normile   SCIENCE

Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics

(2013) P. R. Dormitzer et al.   Science Translational Medicine

Recombinant Hendra viruses expressing a reporter gene retain pathogenicity in ferrets

(2013) Glenn A Marsh et al.   Virology Journal

Development of a novel DNA-launched dengue virus type 2 infectious clone assembled in a bacterial artificial chromosome

(2013) Jose A. Usme-Ciro et al.   VIRUS RESEARCH

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

(2013) F. Almazan et al.   mBio

Immunogenicity and safety of an inactivated 2012/2013 trivalent influenza vaccine produced in mammalian cell culture (Optaflu®)

(2013) Christof David Vinnemeier et al.   Human Vaccines & Immunotherapeutics

Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein

(2013) Nicholas Glanville et al.   PLoS Pathogens

Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

(2013) Everett Clinton Smith et al.   PLoS Pathogens

Many ways to make an influenza virus - review of influenza virus reverse genetics methods

(2012) Othmar G. Engelhardt   Influenza and Other Respiratory Viruses

Molecular Characterization of Feline Infectious Peritonitis Virus Strain DF-2 and Studies of the Role of ORF3abc in Viral Cell Tropism

(2012) A. Balint et al.   JOURNAL OF VIROLOGY

Increased Genetic and Phenotypic Stability of a Promising Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate by Reverse Genetics

(2012) C. Luongo et al.   JOURNAL OF VIROLOGY

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

(2012) Rachel L Graham et al.   NATURE MEDICINE

Structural vaccinology starts to deliver

(2012) Philip R. Dormitzer et al.   NATURE REVIEWS MICROBIOLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis

(2012) Anne L. Hotard et al.   VIROLOGY

Nonclinical phenotypic and genotypic analyses of a Phase 1 pediatric respiratory syncytial virus vaccine candidate MEDI-559 (rA2cp248/404/1030ΔSH) at permissive and non-permissive temperatures

(2012) Jeanne H. Schickli et al.   VIRUS RESEARCH

Attenuation of Neurovirulence, Biodistribution, and Shedding of a Poliovirus:Rhinovirus Chimera after Intrathalamic Inoculation in Macaca fascicularis

(2011) E. Y. Dobrikova et al.   JOURNAL OF VIROLOGY

Coronaviruses

(2011) Mark R. Denison et al.   RNA Biology

Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these years

(2011) Peter L. Collins et al.   VIRUS RESEARCH

Antibodies induced with recombinant VP1 from human rhinovirus exhibit cross-neutralisation

(2010) J. Edlmayr et al.   EUROPEAN RESPIRATORY JOURNAL

Biological challenges and technological opportunities for respiratory syncytial virus vaccine development

(2010) Barney S. Graham   IMMUNOLOGICAL REVIEWS

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5

(2010) Kentaro Yoshii et al.   VIRUS RESEARCH

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

(2010) Lance D. Eckerle et al.   PLoS Pathogens

Trivalent MDCK cell culture-derived influenza vaccine Optaflu®(Novartis Vaccines)

(2009) Alexander Doroshenko et al.   Expert Review of Vaccines

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

The Burden of Respiratory Syncytial Virus Infection in Young Children

(2009) Caroline Breese Hall et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Motavizumab, a Humanized, Enhanced-Potency Monoclonal Antibody for the Prevention of Respiratory Syncytial Virus Infection in At-Risk Children

(2009) Katia Abarca et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution

(2009) Ann C. Palmenberg et al.   SCIENCE

Suitability of PER.C6® cells to generate epidemic and pandemic influenza vaccine strains by reverse genetics

(2009) W. Koudstaal et al.   VACCINE

Preclinical and clinical development of YFV 17D-based chimeric vaccines against dengue, West Nile and Japanese encephalitis viruses

(2009) Bruno Guy et al.   VACCINE

Generation of recombinant pestiviruses using a full-genome amplification strategy

(2009) Thomas Bruun Rasmussen et al.   VETERINARY MICROBIOLOGY

An improved reverse genetics system for generation of bovine viral diarrhea virus as a BAC cDNA

(2008) Zhen-Chuan Fan et al.   JOURNAL OF VIROLOGICAL METHODS

Systematic Assembly of a Full-Length Infectious Clone of Human Coronavirus NL63

(2008) E. F. Donaldson et al.   JOURNAL OF VIROLOGY

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

(2008) M. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA