Review
Immunology
Xiaoqing Liu, Caixia Zhu, Yuyan Wang, Fang Wei, Qiliang Cai
Summary: This review summarizes recent studies on how KSHV manipulates host cell metabolism to promote viral pathogenesis, providing potential therapeutic targets and strategies for KSHV-associated cancers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Virology
Jungang Chen, Jiao Song, Karlie Plaisance-Bonstaff, Shengyu Mu, Steven R. Post, Lu Dai, Zhiqiang Qin
Summary: Although KSHV has been found to cause various human cancers, including KS and PEL, the mechanisms of KSHV-induced tumorigenesis and virus-host interaction network are still not fully understood. Histamine, and its receptors, have been shown to play a role in allergic diseases. Previous data showed that histamine receptor antagonists can effectively inhibit KSHV replication. In this study, histamine treatment was found to promote cell proliferation and growth abilities of KSHV-infected cells, and affect the expression of inflammatory factors.
Review
Virology
Siyu Chen, Yue Deng, Dongli Pan
Summary: Herpesviruses are commonly found human pathogens that have the ability to establish latent infection and reactivate. Both viral and cellular microRNAs play a critical role in regulating the latency process. These findings are significant for understanding the mechanisms of viral replication and latency switch, as well as for developing novel therapeutics.
Article
Biology
Hiroki Kitai, Noritoshi Kato, Koichi Ogami, Shintaro Komatsu, Yu Watanabe, Seiko Yoshino, Eri Koshi, Shoma Tsubota, Yoshio Funahashi, Takahiro Maeda, Kazuhiro Furuhashi, Takuji Ishimoto, Tomoki Kosugi, Shoichi Maruyama, Kenji Kadomatsu, Hiroshi Suzuki
Summary: This study reveals the pathogenic impacts of miRNA regulation on inflammation in systemic lupus erythematosus (SLE) and identifies miR-128 and miR-148a as regulators of KLF4 through seed overlap miRNA cotargeting. The extensive seed overlap is a prevalent feature of broadly conserved miRNAs.
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elham Badrlou, Atefe Abak, Mohammad Taheri
Summary: miRNAs play a significant role in CRC by influencing the expression and activity of CRC-related pathways and interacting with long non-coding RNAs. Levels of miRNAs can be used to distinguish CRC patients from healthy controls. Despite evaluation of therapeutic application of miRNAs in CRC in animal models, it has not been verified in clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Cen Chang, Lingxia Xu, Runrun Zhang, Yehua Jin, Ping Jiang, Kai Wei, Linshuai Xu, Yiming Shi, Jianan Zhao, Momiao Xiong, Shicheng Guo, Dongyi He
Summary: MicroRNAs (miRNAs) play crucial roles in the pathogenesis, diagnosis, and therapeutic intervention of rheumatoid arthritis (RA). They regulate gene expression, immune system differentiation, and serve as potential biomarkers and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Lin Li, Suliman Khan, Song Li, Shengchun Wang, Fang Wang
Summary: Skin malignancies, the most frequent cancers in the world, are classified as melanoma or nonmelanoma cancers, including basal cell carcinoma and squamous cell carcinoma. Noncoding RNA transcripts play critical roles in these cancers, affecting human health significantly.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Soudeh Ghafouri-Fard, Ali Khanbabapour Sasi, Atefe Abak, Hamed Shoorei, Ali Khoshkar, Mohammad Taheri
Summary: miRNAs play a significant role in breast carcinogenesis by modulating key processes and potentially affecting treatment outcomes. Their presence in the peripheral blood of patients also offers a new avenue for non-invasive diagnosis of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Jingyu Song, Jiaxin Wang, Kang Liu, Wenchao Xu, Taotao Sun, Jihong Liu
Summary: Erectile dysfunction, a common male sexual dysfunction disease, is predicted to affect 322 million individuals worldwide by 2025. The pathogenesis of ED is complex and current treatments options are limited. Recent studies have highlighted the significant role of miRNAs in ED, suggesting their potential as therapeutic targets for the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Benjamin Y. F. So, Desmond Y. H. Yap, Tak Mao Chan
Summary: MicroRNAs (miRs) are non-coding small RNAs that play a crucial role in the pathogenesis of lupus nephritis (LN). They are involved in regulating immune cells and inflammatory pathways, and their dysregulation can lead to abnormal immune responses and kidney abnormalities in LN patients. While miRs show promise for various clinical applications in LN, further research is needed to fully understand their clinical utility and address potential safety concerns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: Hepatocellular carcinoma (HCC) is a common and deadly cancer, with a poor prognosis in late stages. Understanding the role of microRNAs (miRNAs) in HCC pathogenesis may lead to improved outcomes. MiRNAs have potential as valuable biomarkers and therapeutic targets in HCC diagnosis and treatment.
Review
Biochemistry & Molecular Biology
Stephen M. Niemiec, Amanda E. Louiselle, Kenneth W. Liechty, Carlos Zgheib
Summary: Pressure ulcers, like other chronic wounds, are preventable yet common conditions that cause significant patient morbidity and high healthcare costs. Impaired wound healing is mainly due to dysregulated immune processes. This review focuses on describing key biochemical pathways in the pathogenesis of pressure ulcers and miRNA regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Zhipan Luo, Fan Yang, Shaocheng Hong, Jianpeng Wang, Bangjie Chen, Liangyun Li, Junfa Yang, Yan Yao, Chenchen Yang, Ying Hu, Shuxian Wang, Tao Xu, Jun Wu
Summary: This article reviewed the roles of miRNAs in the pathogenesis of gouty arthritis and discussed their potential as diagnostic and prognostic relevant biomarkers and as possible therapeutic targets.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pathology
Safoora Pordel, Motahare Khorrami, Fatemeh Saadatpour, Delsuz Rezaee, William C. Cho, Saleheh Jahani, Seyed Mohsen Aghaei-Zarch, Elham Hashemi, Sajad Najafi
Summary: MicroRNA-185 (miR-185) is a short non-coding RNA that has been extensively studied. Its precise functions are not well understood, but increasing evidence suggests its involvement in various physiological processes and pathological conditions. miR-185 has been found to play potential roles in metabolic disorders, asthma, frailty, schizophrenia, and hepatitis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Cell & Tissue Engineering
Lukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Pawel Legosz, Edyta Brzoska
Summary: Heterotopic ossification is the formation of bone in non-osseous tissues, and it can be caused by genetic or non-genetic factors. TGF beta 1, BMPs, activin A, and other factors are known to induce HO. Dysregulation of noncoding RNAs may also play a role in the development of HO.
STEM CELL RESEARCH & THERAPY
(2022)
