Human Immunodeficiency Virus-1 (HIV-1)-Mediated Apoptosis: New Therapeutic Targets

Role of Apoptosis in disease

(2016) B. Favaloro et al.   Aging-US

Tat-Induced FOXO3a Is a Key Mediator of Apoptosis in HIV-1-Infected Human CD4+ T Lymphocytes

(2014) A. Dabrowska et al.   JOURNAL OF IMMUNOLOGY

HIV cure research: Advances and prospects

(2014) Caroline P. Passaes et al.   VIROLOGY

Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein

(2014) W Abbas et al.   Cell Death & Disease

The challenge of HIV associated neurocognitive disorder

(2013) The Lancet Infectious Diseases   LANCET INFECTIOUS DISEASES

Statins, Bcl-2, and Apoptosis: Cell Death or Cell Protection?

(2013) W. Gibson Wood et al.   MOLECULAR NEUROBIOLOGY

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

(2013) Arik Cooper et al.   NATURE

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Altering cell death pathways as an approach to cure HIV infection

(2013) A D Badley et al.   Cell Death & Disease

Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway

(2012) Basant Kumar Thakur et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors

(2012) Arun K. Ghosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of diamond-FET-based RNA aptamer sensing for detection of real sample of HIV-1 Tat protein

(2012) A. Rahim Ruslinda et al.   BIOSENSORS & BIOELECTRONICS

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV

(2012) Nathan W. Cummins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Incomplete Immune Recovery in HIV Infection: Mechanisms, Relevance for Clinical Care, and Possible Solutions

(2012) Julie C. Gaardbo et al.   Clinical & Developmental Immunology

Inhibition of HIV-1 protease expression in T cells owing to DNA aptamer-mediated specific delivery of siRNA

(2012) Qinchang Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HIV-1, reactive oxygen species, and vascular complications

(2012) Kristi M. Porter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition

(2012) Guangtao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Biology of Atherosclerosis: General Paradigms and Distinct Pathogenic Mechanisms Among HIV-Infected Patients

(2012) Janet Lo et al.   JOURNAL OF INFECTIOUS DISEASES

Mechanism of Dissociative Inhibition of HIV Protease and Its Autoprocessing from a Precursor

(2012) Jane M. Sayer et al.   JOURNAL OF MOLECULAR BIOLOGY

Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells

(2012) Debjani Guha et al.   Journal of Neuroinflammation

Inhibition of HIV-1 tat-induced transactivation and apoptosis by the divalent metal chelators, fusaric acid and picolinic acid—Implications for HIV-1 dementia

(2012) Atish Ramautar et al.   NEUROSCIENCE RESEARCH

HIV-1 Promotes Renal Tubular Epithelial Cell Protein Synthesis: Role of mTOR Pathway

(2012) Shabina Rehman et al.   PLoS One

The HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling

(2012) Christelle Marchal et al.   PLoS One

Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2

(2012) Hongtao Liu et al.   PLoS One

Therapeutic potential of HIV protease-activable CASP3

(2012) Kosuke Miyauchi et al.   Scientific Reports

Effects of HIV-1 protease on cellular functions and their potential applications in antiretroviral therapy

(2012) Hailiu Yang et al.   Cell and Bioscience

HIV-1 induces NALP3-inflammasome expression and interleukin-1β secretion in dendritic cells from healthy individuals but not from HIV-positive patients

(2011) Alessandra Pontillo et al.   AIDS

Human Immunodeficiency Virus nef Signature Sequences Are Associated with Pulmonary Hypertension

(2011) Sharilyn Almodovar et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Recent Progress in HIV-Associated Nephropathy

(2011) Christina M. Wyatt et al.   Annual Review of Medicine

Aptamer beacons for visualization of endogenous protein HIV-1 reverse transcriptase in living cells

(2011) Yu Liang et al.   BIOSENSORS & BIOELECTRONICS

Inhibition of  -TrcP-dependent ubiquitination of p53 by HIV-1 Vpu promotes p53-mediated apoptosis in human T cells

(2011) S. Verma et al.   BLOOD

Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in bcl-2 expression in mouse neuronal cultures

(2011) Yulin Zhang et al.   BRAIN RESEARCH

Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network

(2011) V. Audrito et al.   CANCER RESEARCH

HIV ENV Glycoprotein-mediated Bystander Apoptosis Depends on Expression of the CCR5 Co-receptor at the Cell Surface and ENV Fusogenic Activity

(2011) Anjali Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

The molecular pathogenesis of HIV-1 associated nephropathy: recent advances

(2011) Natalia Papeta et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The HIV-1-Specific Protein Casp8p41 Induces Death of Infected Cells through Bax/Bak

(2011) A. M. Sainski et al.   JOURNAL OF VIROLOGY

Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 Inhibition

(2011) Jiehua Zhou et al.   METHODS

Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail

(2011) K. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Broad-Spectrum Antiviral Therapeutics

(2011) Todd H. Rider et al.   PLoS One

The HIV-1 Transactivator Factor (Tat) Induces Enterocyte Apoptosis through a Redox-Mediated Mechanism

(2011) Vittoria Buccigrossi et al.   PLoS One

Modulation of HIV-1-host interaction: role of the Vpu accessory protein

(2011) Mathieu Dubé et al.   Retrovirology

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice

(2011) Himanshu Garg et al.   Virology Journal

CD4+ T Cell Depletion in Human Immunodeficiency Virus (HIV) Infection: Role of Apoptosis

(2011) Michèle Février et al.   Viruses-Basel

HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells

(2010) Alexandra Snyder et al.   AIDS

Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART

(2010) Alberto Zalar et al.   ANTIVIRAL RESEARCH

HIV-1 protease inhibition potential of functionalized polyoxometalates

(2010) Andreas Flütsch et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The protective effect of tianeptine on Gp120-induced apoptosis in astroglial cells: role of GS and NOS, and NF-κB suppression

(2010) Elzbieta Janda et al.   BRITISH JOURNAL OF PHARMACOLOGY

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

(2010) Gilad Doitsh et al.   CELL

Systems biology of apoptosis signaling networks

(2010) Inna N Lavrik   CURRENT OPINION IN BIOTECHNOLOGY

Exogenous Nef Is an Inhibitor ofMycobacterium tuberculosis-induced Tumor Necrosis Factor-α Production and Macrophage Apoptosis

(2010) Kuldeep Kumawat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eEF1A: Thinking Outside the Ribosome

(2010) Maria K. Mateyak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Casp8p41 Content Is Inversely Associated with CD4 T Cell Count

(2010) Nathan W. Cummins et al.   JOURNAL OF INFECTIOUS DISEASES

Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes

(2010) Lihong Huo et al.   JOURNAL OF PATHOLOGY

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

HIV-1 assembly in macrophages

(2010) Philippe Benaroch et al.   Retrovirology

Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

(2010) Michael Schindler et al.   Retrovirology

An emerging role for p21-activated kinases (Paks) in viral infections

(2010) Celine Van den Broeke et al.   TRENDS IN CELL BIOLOGY

Induction of cytopathic effects and apoptosis in Spodoptera frugiperda cells by the HIV-1 Env glycoprotein signal peptide

(2010) Chad James Michalski et al.   VIRUS GENES

Mechanisms of HIV-associated lymphocyte apoptosis: 2010

(2010) N W Cummins et al.   Cell Death & Disease

Escape of HIV-1-Infected Dendritic Cells from TRAIL-Mediated NK Cell Cytotoxicity during NK-DC Cross-Talk—A Pivotal Role of HMGB1

(2010) Marie-Thérèse Melki et al.   PLoS Pathogens

Patients with Discordant Responses to Antiretroviral Therapy Have Impaired Killing of HIV-Infected T Cells

(2010) Sekar Natesampillai et al.   PLoS Pathogens

Mechanisms of HIV envelope-induced T lymphocyte apoptosis

(2010) Zhi-Tao Wan et al.   VIROLOGICA SINICA

Nanotechnology-based systems for the treatment and prevention of HIV/AIDS

(2009) José das Neves et al.   ADVANCED DRUG DELIVERY REVIEWS

Altered Bystander Apoptosis Induction and Pathogenesis of Enfuvirtide-Resistant HIV Type 1 Env Mutants

(2009) Himanshu Garg et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients

(2009) G. Stary et al.   BLOOD

Synthesis and evaluation of A-seco type triterpenoids for anti-HIV-1protease activity

(2009) Ying Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

NAP protects against cytochrome c release: Inhibition of the initiation of apoptosis

(2009) Ilona Zemlyak et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies∞

(2009) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Controversies in the pathogenesis of HIV-associated renal diseases

(2009) Leslie A. Bruggeman et al.   Nature Reviews Nephrology

DNA double strand break repair enzymes function at multiple steps in retroviral infection

(2009) Yasuteru Sakurai et al.   Retrovirology

Role of the Fas/FasL pathway in HIV or SIV disease

(2009) Bhawna Poonia et al.   Retrovirology

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Humanized Rag2−/−γc−/− (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year

(2009) Bradford K. Berges et al.   VIROLOGY

GRL-02031, a Novel Nonpeptidic Protease Inhibitor (PI) Containing a Stereochemically Defined Fused Cyclopentanyltetrahydrofuran Potent against Multi-PI-Resistant Human Immunodeficiency Virus Type 1 In Vitro

(2008) Y. Koh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses

(2008) F. Groot et al.   BLOOD

Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection

(2008) X. Wang et al.   BLOOD

Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation

(2008) Hye-Sook Kwon et al.   Cell Host & Microbe

Role of HIV Gp41 mediated fusion/hemifusion in bystander apoptosis

(2008) H. Garg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Apoptosis and HIV Infection: About Molecules and Genes

(2008) Andrea Cossarizza   CURRENT PHARMACEUTICAL DESIGN

Histological variants of cutaneous Kaposi sarcoma

(2008) Wayne Grayson et al.   Diagnostic Pathology

HIV-1 Vpr: Mechanisms of G2 arrest and apoptosis

(2008) Joshua L. Andersen et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV

(2008) Erik De Clercq   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Design and Evaluation of Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

(2008) Yuxian He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

(2008) Felix Kratz   JOURNAL OF CONTROLLED RELEASE

HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells

(2008) Paul E. Rosenstiel et al.   KIDNEY INTERNATIONAL

HIV Protease Inhibitors Impact on Apoptosis

(2008) Stacey Rizza et al.   Medicinal Chemistry

Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease

(2008) Chun Tang et al.   NATURE

Design and Synthesis of Stereochemically Defined Novel Spirocyclic P2-Ligands for HIV-1 Protease Inhibitors

(2008) Arun K. Ghosh et al.   ORGANIC LETTERS

Solid Lipid Nanoparticles Enhance the Delivery of the HIV Protease Inhibitor, Atazanavir, by a Human Brain Endothelial Cell Line

(2008) Niladri Chattopadhyay et al.   PHARMACEUTICAL RESEARCH

Infected Cell Killing by HIV-1 Protease Promotes NF-κB Dependent HIV-1 Replication

(2008) Gary D. Bren et al.   PLoS One

Bcl-2 mediated modulation of vascularization in prostate cancer xenografts

(2008) Yoshihisa Sakai et al.   PROSTATE

Enantioselective synthesis of cyclopentyltetrahydrofuran (Cp-THF), an important high-affinity P2-ligand for HIV-1 protease inhibitors

(2008) Arun K. Ghosh et al.   TETRAHEDRON LETTERS

Is HIV infection a TNF receptor signalling-driven disease?

(2008) Georges Herbein et al.   TRENDS IN IMMUNOLOGY

Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-β by protein kinase C

(2007) S. Jajoo et al.   NEUROSCIENCE