Journal
VIRUSES-BASEL
Volume 5, Issue 7, Pages 1633-1645Publisher
MDPI
DOI: 10.3390/v5071633
Keywords
HIV; non-coding RNA; chromatin remodeling; latency; reactivation
Categories
Funding
- NIAID [R56 AI096861-01, PO1 AI099783-01]
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HIV is a chronic viral infection affecting an estimated 34 million people worldwide. Current therapies employ the use of a cocktail of antiretroviral medications to reduce the spread and effects of HIV, however complete eradication from an individual currently remains unattainable. Viral latency and regulation of gene expression is a key consideration when developing effective treatments. While our understanding of these processes remains incomplete new developments suggest that non-coding RNA (ncRNA) mediated regulation may provide an avenue to controlling both viral expression and latency. Here we discuss the importance of known regulatory mechanisms and suggest directions for further study, in particular the use ncRNAs in controlling HIV expression.
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