Article
Microbiology
Yvonne C. F. Su, Danielle E. Anderson, Barnaby E. Young, Martin Linster, Feng Zhu, Jayanthi Jayakumar, Yan Zhuang, Shirin Kalimuddin, Jenny G. H. Low, Chee Wah Tan, Wan Ni Chia, Tze Minn Mak, Sophie Octavia, Jean-Marc Chavatte, Raphael T. C. Lee, Surinder Pada, Seow Yen Tan, Louisa Sun, Gabriel Z. Yan, Sebastian Maurer-Stroh, Ian H. Mendenhall, Yee-Sin Leo, David Chien Lye, Lin-Fa Wang, Gavin J. D. Smith
Article
Microbiology
Laurent Dembele, Jean-Francois Franetich, Valerie Soulard, Nadia Amanzougaghene, Shahin Tajeri, Teun Bousema, Geert-Jan van Gemert, Roger Le Grand, Nathalie Dereuddre-Bosquet, J. Kevin Baird, Dominique Mazier, Georges Snounou
Summary: This study found that chloroquine can potentiate the activity of 8-aminoquinoline compound primaquine against several malarial parasites in normal primary hepatocytes, but not in a hepatocarcinoma cell line.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Mackenzie L. Kwak, Jean-Marc Chavatte, Ka Lip Chew, Benjamin P. Y. -H. Lee
Summary: Despite the significant public health risk posed by ticks, research on the diversity of ticks and tick-borne diseases in Singapore has been limited until recently. Only fourteen tick species in five genera have been recorded in Singapore so far. Dermacentor auratus, found in Singapore for the first time, has been identified on a range of hosts, including humans, with DNA sequences at 2 loci provided for further analysis and discussion on the health risk it poses in Singapore.
TICKS AND TICK-BORNE DISEASES
(2021)
Editorial Material
Medicine, General & Internal
Jean-Marc Chavatte, Georges Snounou
Article
Microbiology
Benoit Malleret, Abbas El Sahili, Matthew Zirui Tay, Guillaume Carissimo, Alice Soh Meoy Ong, Wisna Novera, Jianqing Lin, Rossarin Suwanarusk, Varakorn Kosaisavee, Trang T. T. Chu, Ameya Sinha, Shanshan Wu Howland, Yiping Fan, Jakub Gruszczyk, Wai-Hong Tham, Yves Colin, Sebastian Maurer-Stroh, Georges Snounou, Lisa F. P. Ng, Jerry Kok Yen Chan, Ann-Marie Chacko, Julien Lescar, Rajesh Chandramohanadas, Francois Nosten, Bruce Russell, Laurent Renia
Summary: This study identified CD98 heavy chain as a receptor for the PvRBP2a parasite ligand, further demonstrating its role in P. vivax reticulocyte invasion. The interaction between CD98 and PvRBP2a suggests its potential as a vaccine target against P. vivax malaria.
NATURE MICROBIOLOGY
(2021)
Article
Infectious Diseases
Po Ying Chia, Sean Wei Xiang Ong, Calvin J. Chiew, Li Wei Ang, Jean-Marc Chavatte, Tze-Minn Mak, Lin Cui, Shirin Kalimuddin, Wan Ni Chia, Chee Wah Tan, Louis Yi Ann Chai, Seow Yen Tan, Shuwei Zheng, Raymond Tzer Pin Lin, Linfa Wang, Yee-Sin Leo, Vernon J. Lee, David Chien Lye, Barnaby Edward Young
Summary: This study found that mRNA vaccines are highly effective at preventing symptomatic and severe COVID-19 associated with B.1.617.2 infection. Vaccination is associated with a faster decline in viral RNA load and a robust serological response.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Medicine, Research & Experimental
Matthew Zirui Tay, Angeline Rouers, Siew-Wai Fong, Yun Shan Goh, Yi-Hao Chan, Zi Wei Chang, Weili Xu, Chee Wah Tan, Wan Ni Chia, Anthony Torres-Ruesta, Siti Naqiah Amrun, Yuling Huang, Pei Xiang Hor, Chiew Yee Loh, Nicholas Kim-Wah Yeo, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Jean-Marc Chavatte, Alicia Jieling Lim, Sebastian Maurer-Stroh, Lin-Fa Wang, Raymond Valentine Tzer Pin Lin, Cheng- Wang, Seow-Yen Tan, Barnaby Edward Young, Yee-Sin Leo, David C. Lye, Laurent Renia, Lisa F. P. Ng
Summary: The study found that the Delta variant of the SARS-CoV-2 virus can infect vaccinated individuals. Vaccine breakthrough cases showed lower memory B cell frequencies against the SARS-CoV-2 receptor-binding domain, but antibodies secreted by memory B cells retained neutralizing properties against the Delta variant. Inflammatory cytokines were lower in vaccine breakthrough infections compared to primary infections, highlighting the importance of vaccination in preventing inflammation.
EMBO MOLECULAR MEDICINE
(2022)
Review
Parasitology
Richard Culleton, Arnab Pain, Georges Snounou
Summary: Plasmodium malariae is a neglected malaria parasite, with less research conducted compared to its more notorious cousins, P. falciparum and P. vivax. However, there has been increasing interest in this parasite due to improved detection techniques revealing a wider prevalence and high numbers of chronic, asymptomatic infections, particularly in Africa.
TRENDS IN PARASITOLOGY
(2023)
Article
Health Care Sciences & Services
Bei Wang, Yun Shan Goh, Siew-Wai Fong, Barnaby Edward Young, Eve Zi Xian Ngoh, Jean-Marc Chavatte, Siti Nazihah Mohd Salleh, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Pei Xiang Hor, Chiew Yee Loh, Chia Yin Lee, Yi-Hao Chan, Zi Wei Chang, Matthew Zirui Tay, Angeline Rouers, Anthony Torres-Ruesta, Guillaume Carissimo, Mun Kuen Soh, Raphael Tze Chuen Lee, Yani Xu, Surinder Pada, Raymond Tzer Pin Lin, Yee-Sin Leo, David C. Lye, Sebastian Maurer-Stroh, Lisa F. P. Ng, Laurent Renia, Cheng- Wang
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Parasitology
Milan Thorel, Jean-Marc Chavatte, Irene Landau, Karin Lemberger, Antoine Leclerc
Summary: This is the first reported case of P. relictum lineage pGRW11 infection in a common Eider. Despite oral doxycycline treatment, the bird died rapidly due to severe internal hemorrhages and amyloidosis.
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
(2021)
Article
Cell Biology
Yun Shan Goh, Jean-Marc Chavatte, Alicia Lim Jieling, Bernett Lee, Pei Xiang Hor, Siti Naqiah Amrun, Cheryl Yi-Pin Lee, Rhonda Sin-Ling Chee, Bei Wang, Chia Yin Lee, Eve Zhi Xian Ngoh, Cheng- Wang, Barnaby Edward Young, Paul A. Tambyah, Shirin Kalimuddin, Surinder Pada, Seow-Yen Tan, Louisa Jin Sun, Mark I-Cheng Chen, Yee-Sin Leo, David C. Lye, Lisa F. P. Ng, Raymond Tzer Pin Lin, Laurent Renia
Summary: Early detection of infection is crucial in limiting the spread of COVID-19, and a flow cytometry-based assay has been developed to detect SARS-CoV-2 spike protein antibodies in COVID-19 patients. The antibody response is significantly higher in later stages of infection, and the assay can also detect antibodies in asymptomatic individuals with high sensitivity, demonstrating its potential for serological analysis of both symptomatic and asymptomatic infections.
CELL REPORTS MEDICINE
(2021)
Article
Parasitology
Jean-Marc Chavatte, Sophie Octavia
Summary: The complete mitochondrial genome of Dermacentor auratus was sequenced using long-range PCR and assembled into a circularized genome, confirming its phylogenetic position within the Dermacentor clade.
Article
Infectious Diseases
Sean Wei Xiang Ong, Jean-Marc Chavatte, Jonathan Wei Zhong Chia, Ramez Wadie Kirollos, Yih Yian Sitoh, Cristine Ding, Monica Chan
CASE REPORTS IN INFECTIOUS DISEASES
(2020)
Letter
Immunology
Poh-Lian Lim, Jean-Marc Chavatte, Shawn Vasoo, Jonathan Yang
EMERGING INFECTIOUS DISEASES
(2020)
