Article
Biochemistry & Molecular Biology
Kyung-Min Kwon, Myung-Jun Lee, Han-Saem Chung, Jae-Hong Pak, Chang-Jin Jeon
Summary: In this study, the organization of SST neurons in the Mongolian gerbil visual cortex was characterized using immunocytochemistry, quantitative analysis, and confocal microscopy. The results showed distinct features of SST neurons and provided some insight into their afferent circuitry in the gerbil VC. These findings may support future studies investigating the role of SST neurons in visual processing.
Article
Biochemistry & Molecular Biology
Jae-Rim Son, Xin-Yu Kuai, Chang-Jin Jeon
Summary: This study investigates the localization of calcium-binding proteins (CBPs) in the visual cortex of the Mongolian gerbil and compares them to gamma-aminobutyric acid (GABA) and nitric oxide synthase (NOS) neurons. The results show that CBPs are abundantly and distinctively distributed in specific layers of the visual cortex, with a small population of GABAergic neurons and no expression of NOS.
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
(2023)
Article
Cell Biology
Myung-Jun Lee, Won-Tae Lee, Chang-Jin Jeon
Summary: NPY-IR neurons in the gerbil visual cortex exhibit unique characteristics and play a specific role in the visual process of diurnal animals, showing notable architecture and interactions with GABAergic interneurons.
Article
Psychiatry
Samuel J. Dienel, Kenneth N. Fish, David A. Lewis
Summary: A study found that mRNA levels of somatostatin (SST) and parvalbumin (PV) are lower in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia. It is unclear whether this is due to lower transcript levels per neuron or fewer neurons. Distinguishing between these possibilities is crucial for understanding DLPFC dysfunction in schizophrenia and developing new treatments.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Cell Biology
Elizabeth S. Chan, Yang Ge, Yee Wah So, Yun-Fei Bai, Lidong Liu, Yu Tian Wang
Summary: This study identifies netrin-1 as an endogenous allosteric modulator of GABAAR, which plays an important role in maintaining the balance between neuronal excitation and inhibition.
Article
Neurosciences
Ingrid Reichenberger, Claude J. Caussidier-Dechesne, Hans Straka
Summary: Calcium-binding protein calretinin is found in auditory but not vestibular afferent fibers in frogs, with differential distribution in sensory epithelia and ganglion cells. The absence of calretinin in vestibular ganglion cells is likely related to the lack of type I hair cells in anamniote vertebrates. The presence of calretinin in hair cells may play a role in encoding self-motion versus acoustic stimuli in frogs.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Thomas Prevot, Etienne Sibille
Summary: Cognitive dysfunctions are a common occurrence in depression, other psychiatric disorders, and aging, potentially linked to altered GABA activity, specifically involving a decrease in the function of SST+ GABA neurons, leading to cognitive impairments.
MOLECULAR PSYCHIATRY
(2021)
Article
Chemistry, Applied
Zhendong He, Jing Zhao, Changqi Liu, Weiwei Li, Yaosong Wang
Summary: The study showed that adding different concentrations of GABA had significant effects on the physical properties of whey protein isolate films. Low concentrations of GABA improved hydration and thermal properties, while high concentrations of GABA caused impairment in these properties.
FOOD HYDROCOLLOIDS
(2022)
Article
Immunology
Jinxiang Jiang, Binliang Tang, Lei Wang, Qingwei Huo, Shuyi Tan, Afzal Misrani, Yuanyuan Han, Huidong Li, Haidong Hu, Jichen Wang, Tinghui Cheng, Sidra Tabassum, Ming Chen, Wenyuan Xie, Cheng Long, Li Yang
Summary: Neuroinflammation induced by LPS leads to increased inhibitory postsynaptic currents in glutamatergic neurons, associated with excessive microglial activation. Minocycline can block microglial activation, improve abnormal GABA signaling protein expression, and prevent LPS-induced behavioral abnormalities.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Eun-Jin Kim, Oh-Sang Kwon, Chang-Gi Hur, Marie Merci Nyiramana, Dong-Kun Lee, Seong-Geun Hong, Jaehee Han, Dawon Kang
Summary: This study identified the effect of GABAR agonists on K-2P channel expression and activity in neuroblastic B35 cells. Muscimol, a GABA(A)R agonist, was found to significantly increase TREK-2 expression and activity, potentially reducing cellular excitability in GABAergic neurons through activating the TREK-2 channel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Multidisciplinary
Eun Namgung, Jungyoon Kim, Hyeonseok Jeong, Jiyoung Ma, Gahae Hong, Ilhyang Kang, Jinsol Kim, Yoonji Joo, Rye Young Kim, In Kyoon Lyoo
Summary: Computerized relaxation training was found to significantly improve stress-related symptoms in women with psychological distress by reducing prefrontal GABA levels and increasing relative CBF.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kazuya Matsuo, Yasushi Yabuki, Ronald Melki, Luc Bousset, Yuji Owada, Kohji Fukunaga
Summary: The study demonstrates that injecting α-Syn fibrils into the dorsal striatum impairs cognition and leads to the accumulation of phosphorylated α-Syn and reduction of GABAergic neurons in the medial septum/diagonal band. Deletion of Fabp3 antagonizes the neurotoxicity of α-Syn and cognitive impairment, suggesting that FABP3 could be a therapeutic target for dementia in synucleinopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yinan Shen, Feng Liu, Jiazhi Duan, Wenhan Wang, Hongru Yang, Zizhao Wang, Tailin Wang, Ying Kong, Baojin Ma, Min Hao, Hang Zhao, Hong Liu
Summary: Directed differentiation can accelerate the regeneration of specific types of neurons, as demonstrated by the promotion of GABAergic neurogenesis through HAp nanorods. The mechanism involves lysosome-mediated degradation increasing intracellular calcium concentrations, leading to the suppression of specific gene expression and activation of c-Jun. This discovery provides opportunities for efficient and precise stem cell therapy for neurodegenerative diseases.
Article
Agronomy
Maryam Saeedi, Seyed Hossein Mirdehghan, Fatemeh Nazoori, Majid Esmaeilizadeh, Mahmoud Koushesh Saba
Summary: Spraying fresh in-hull pistachio fruit with GABA, CaO, and their combination can reduce weight loss and color change, maintain antioxidant activity of kernel, and lower respiration rate and microbial activity. The GABA + CaO treatment showed the best effect in maintaining the physical, biochemical, and visual characteristics of fresh pistachio for marketing purposes.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Behavioral Sciences
Karlene S. Stoby, Sara A. Rafique, Georg Oeltzschner, Jennifer K. E. Steeves
Summary: This study investigated the effects of iTBS and cTBS on the primary visual cortex. The results showed that these protocols did not significantly affect the levels of GABA+ and Glx. However, TBS did alter the relationship between GABA+ and Glx for up to 1 hour after stimulation.
BRAIN AND BEHAVIOR
(2022)