Article
Cell Biology
Fen Xiao, Chen-Yi Tang, Hao-Neng Tang, Hui-Xuan Wu, Nan Hu, Long Li, Hou-De Zhou
Summary: This study revealed that Lnc-FR332443 inhibits adipogenesis by regulating the expression of Runx1, suggesting it as a potential drug target for obesity prevention and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shohei Fukada, Kouji Ohta, Miyuki Sakuma, Misaki Akagi, Hiroki Kato, Takako Naruse, Takayuki Nakagawa, Hideo Shigeishi, Hiromi Nishi, Masaaki Takechi, Tomonao Aikawa
Summary: This study found that Sunitinib treatment can cause cell injury and apoptosis in oral keratinocytes, which is promoted by p38 activation and STAT3 downregulation. These findings suggest that oral mucosal complications may be associated with the cytotoxic effects of Sunitinib on oral keratinocytes.
Article
Endocrinology & Metabolism
Peibei Sun, Yayan Wang, Tian Gao, Kun Li, Dongwang Zheng, Ajuan Liu, Ya Ni
Summary: The study found that Hsp90 is involved in human sperm hyperactivation and acrosome reaction. Hsp90 forms a protein complex with Cdc37 to regulate the kinase activity of Erk1/2 and p38, thus controlling human sperm capacitation through these pathways.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Immunology
Yixiu Tao, Yingxin Sun, Bo Wu, Donghui Xu, Jun Yang, Liang Gu, Chunling Du
Summary: FOXA2 is underexpressed in CS-exposed mouse lungs, associated with cell senescence and inflammation. Overexpression of FOXA2 delays senescence and inflammation, potentially through regulation of the p38 and Erk1/2 MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kecheng Tang, Bin Zhong, Qingman Luo, Qiao Liu, Xin Chen, Dayan Cao, Xiaohui Li, Shengqian Yang
Summary: This study demonstrates that phillyrin effectively alleviates catecholamine-induced cardiac hypertrophy and inflammatory response by suppressing the p38 MAPK/ERK1/2 and AKT/NF-xB signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michael A. Fawzy, Sherif A. Maher, Sally M. Bakkar, Mahmoud A. El-Rehany, Moustafa Fathy
Summary: This study demonstrated the protective effect of pantoprazole on renal ischemia/reperfusion injury in rats for the first time, by suppressing apoptosis, reducing pro-inflammatory cytokines levels, and impacting intracellular signaling pathways. Moreover, multiple doses of pantoprazole showed a greater therapeutic effect than a single dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Yixuan Jiang, Na Xin, Yi Xiong, Yanjun Guo, Ying Yuan, Qin Zhang, Ping Gong
Summary: α-calcitonin gene-related peptide (αCGRP) plays a crucial role in regulating osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through the mitogen-activated protein kinase (MAPK) signaling pathway. Activation of αCGRP leads to increased phosphorylation of ERK1/2 and p38 MAPK, resulting in upregulated expression of osteogenic genes and enhanced formation of alkaline phosphatase and calcified nodules. Inhibition of this signaling pathway impairs BMSCs' osteogenic differentiation, proliferation, and apoptosis.
CELL TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Wei-Wen Sung, Yun-Yu Lin, Shen-Da Huang, Hsueh-Ling Cheng
Summary: The exopolysaccharide preparation of Bacillus amyloliquefaciens displayed anti-inflammatory activity by reducing the expression of proinflammatory factors and oxidative stress, and ameliorating ear inflammation in mice. The underlying mechanism involves inhibition of the nuclear factor-kappa B pathway, activation of the mitogen-activated protein kinase p38 and the anti-oxidative nuclear factor erythroid 2-related factor 2 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Claudia Metz, Claudia Oyanadel, Juan Jung, Claudio Retamal, Jorge Cancino, Jonathan Barra, Jaime Venegas, Guangwei Du, Andrea Soza, Alfonso Gonzalez
Summary: The PA/PDE4/PKA pathway triggers EGFR endocytosis through activation of p38 and ERK1/2, expanding the potential for EGFR transmodulation and interference in cancer.
Article
Medicine, Research & Experimental
Jingyuan Wen, Zhengsheng Bao, Lunxin Li, Yingquan Liu, Bing Wei, Xiaoang Ye, Huihui Xu, Longkang Cui, Xuefei Li, Gaobo Shen, Yuan Fang, Hanbing Zeng, Zhe Shen, Enping Guo, Hongting Jin, Lianguo Wu
Summary: Through network pharmacological analysis, this study found that Qiangguyin (QGY) can reduce fat accumulation in the chondro-osseous junction by activating the mitogen-activated protein kinase (MAPK) signaling pathway, thereby reducing decreased bone density and increased bone fragility in postmenopausal osteoporosis (PMOP) patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Dermatology
Xiaoyuan Hou, Jiaqi Shi, Li Sun, Lebin Song, Wene Zhao, Xixi Xiong, Yan Lu
Summary: Oxidative stress induces premature senescence of melanocytes and disrupts melanosome transfer by activating the ERK1/2 and p38 MAPK pathways.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Haorong He, Huadong Yin, Xueke Yu, Yao Zhang, Menggen Ma, Diyan Li, Qing Zhu
Summary: This study demonstrated that PDLIM5 can promote proliferation and differentiation of chicken skeletal muscle satellite cells through the p38-MAPK pathway. These findings suggest that PDLIM5 may play a role in the growth and development of chicken skeletal muscle.
Article
Cell Biology
Yan Deng, Ling Li, Jia-Hui Zhu, Pei-Pei Li, Yi-Xuan Deng, Hong-Hong Luo, Yuan-Yuan Yang, Bai-Cheng He, Yuxi Su
Summary: This study demonstrates that overexpression of COX-2 enhances BMP9's osteogenic ability through upregulation of TGF-beta 1, resulting in the activation of p38 signaling pathway in MSCs.
Article
Pharmacology & Pharmacy
Baocheng Xie, Zhanwei Zeng, Shiyi Liao, Chenhui Zhou, Longhuo Wu, Daohua Xu
Summary: Kaempferol exhibits beneficial effects on osteogenic differentiation and counteracts the inhibitory activity of dexamethasone by activating JNK and p38-MAPK signaling pathways, improving bone mineralization. This potential makes it a promising candidate for developing new drugs for treating glucocorticoid-induced osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Ranjan Koirala, Chanida Fongsaran, Tanisha Poston, Matthew Rogge, Bryan Rogers, Ronald Thune, Lidiya Dubytska
Summary: In this study, we demonstrated that EseN inactivates multiple signaling pathways and modulates cell death in infected head-kidney-derived macrophages. Additionally, EseN is involved in the regulation of IL-10, baxa and p53 mRNA expression.
MICROBIOLOGY SPECTRUM
(2023)
