Article
Radiology, Nuclear Medicine & Medical Imaging
Maude Gondre, Mireille Conrad, Veronique Vallet, Jean Bourhis, Francois Bochud, Raphael Moeckli
Summary: A study was conducted to create and validate beam models for CyberKnife within RaySearch's treatment planning system. The models demonstrated high accuracy and reliability for clinical use, with dose differences within acceptable limits for all collimators and algorithms tested.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Damian Czarnecki, Klemens Zink, Mohamad Alissa, Veronika Flatten, Teresa Espelage, Andreas A. Schoenfeld
Summary: This study investigated the ability of the IC Profiler detector array to measure photon beam quality and developed a Monte Carlo-based model for validation. The results showed that the Monte Carlo simulations were consistent with the measurements, demonstrating the reliability of the model. Furthermore, the model can be used for further research on the effects of beam parameter variations on AR ratios and %dd(10)x$_\textrm {{\it x}}$.
Article
Nuclear Science & Technology
A. Albqoor, E. Ababneh, S. Okoor, I. Zahran
Summary: The mechanics of photon and electron interactions were verified using a developed Brachytherapy computer code for high Dose Rate (HDR). By comparing photon cross-sections from multiple physics libraries in the code, the results were benchmarked against experimental and theoretical findings. The Klein-Nishina and experimental cross-section results were in good agreement with those from the Livermore library. The range of the first scattered electron, measured within 1 mm and 2 mm for two therapeutically relevant materials, has significant implications for interpreting kernel dose spikes observed in previous research.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Chunbo Liu, Yawei Zhang, Zuofeng Li, Xiaoying Liang, Jiyeon Park, Yuntao Song, Hansheng Feng
Summary: This study developed and validated a Monte Carlo beam model for Proteus-ONE proton therapy system. The results showed good agreement between TOPAS simulation and measurement, indicating the accuracy and reliability of the obtained beam model, with potential clinical or research applications.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Chemistry, Physical
Iswan Fadhil Maulana, Sitti Yani, Tony Sumaryada, Mohamad Fahdillah Rhani, Freddy Haryanto
Summary: Commissioning of the Linac Flattening Filter-Free (FFF) Elekta InfinityTM 6 MV photon mode was performed using Monte Carlo simulation, showing that the simulated dose distribution satisfied acceptance criteria with an average local difference of 2.99% PDD. Dose and Dmax increased with higher initial electron energy, while PDD decreased at smaller field sizes. The dose profile widened and the PDD of Linac FFF decreased more significantly than Linac FF at larger field sizes, with both exhibiting differences in dose uniformity in the umbra area.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Oncology
Naonori Hu, Hiroki Tanaka, Ryo Kakino, Syuushi Yoshikawa, Mamoru Miyao, Kazuhiko Akita, Kayako Isohashi, Teruhito Aihara, Keiji Nihei, Koji Ono
Summary: Boron neutron capture therapy (BNCT) has been approved for the treatment of unresectable, locally advanced, and recurrent head and neck cancer by the Japanese government. A new treatment planning system, NeuCure (R) Dose Engine, has been developed for clinical BNCT. Comparisons between simulated and experimental results show the system's safety and efficacy, with close matches in dose distribution inside a head phantom.
RADIATION ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Masashi Yagi, Toshiro Tsubouchi, Noriaki Hamatani, Masaaki Takashina, Hiroyasu Maruo, Shinichiro Fujitaka, Hideaki Nihongi, Kazuhiko Ogawa, Tatsuaki Kanai
Summary: This study reports the experience of commissioning a commercial treatment planning system for fast-raster scanning of carbon-ion beams. The system utilized an analytical dose calculation algorithm and a beam model to consider lateral heterogeneity. The physical and biological dose models were validated and showed acceptable accuracy in clinical situations. The study concludes that the newly developed system can be used clinically, although accuracy may be limited in heterogeneous media.
Article
Engineering, Biomedical
S. Mueller, G. Guyer, W. Volken, D. Frei, N. Torelli, D. M. Aebersold, P. Manser, M. K. Fix
Summary: The goal of this study is to improve the computational efficiency of a fully MC based treatment planning process for intensity modulated treatment plans. By implementing multiple methods and studying their parameters, the researchers were able to significantly reduce computation times without substantial degradation in final plan quality.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Mechanics
Haibing Peng
Summary: Despite the widespread use of Navier-Stokes equations in computational-fluid-dynamics (CFD), there are still unanswered questions due to the absence of considering the statistical nature of discrete air molecules. In this study, we propose a statistical mechanics-based approach called the volume-element method, which allows for the numerical evaluation of aerodynamic lift and drag. We obtained pressure and friction values as a function of the angle of attack for flat-plate airfoils, and this method can be directly applied to convex-shape airfoils and combined with Monte Carlo simulations for concave-shape airfoils. This approach not only has implications for aerodynamic applications, but also opens up possibilities for further applications in Boson or Fermi gases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cory Knill, Raminder Sandhu, Brian Loughery, Lifeng Lin, Robert Halford, Doug Drake, Michael Snyder
Summary: In this study, researchers developed a 6FFF Monte Carlo (MC) dose calculation algorithm for spine stereotactic radiosurgery (SRS) and validated it for clinical use.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jose Paredes-Pacheco, Francisco Javier Lopez-Gonzalez, Jesus Silva-Rodriguez, Nikos Efthimiou, Aida Ninerola-Baizan, Alvaro Ruibal, Nuria Roe-Vellve, Pablo Aguiar
Summary: SimPET is a free cloud-based platform for generating realistic brain PET data and has been validated by comparing simulated images with real data. The platform utilizes automatic scripts for code execution and can efficiently generate realistic PET images. Validation results show slight differences between simulated and real images, indicating a need for further investigation.
Article
Physics, Multidisciplinary
Jan Gajewski, Magdalena Garbacz, Chih-Wei Chang, Katarzyna Czerska, Marco Durante, Nils Krah, Katarzyna Krzempek, Renata Kopec, Liyong Lin, Natalia Mojzeszek, Vincenzo Patera, Monika Pawlik-Niedzwiecka, Ilaria Rinaldi, Marzena Rydygier, Elzbieta Pluta, Emanuele Scifoni, Agata Skrzypek, Francesco Tommasino, Angelo Schiavi, Antoni Rucinski
Summary: In this study, commissioning and validation of the GPU-accelerated Monte Carlo code FRED were conducted for proton beam therapy facilities with different beam line designs. The automated procedure to build a parameter library characterizing the clinical proton pencil beam was successful in achieving submillimeter agreement with conventional measurements, demonstrating the potential clinical applicability of FRED.
FRONTIERS IN PHYSICS
(2021)
Article
Chemistry, Physical
Ravindra Shende, S. J. Dhoble, Gourav Gupta
Summary: This study conducted geometrical source modeling and commissioning validation of 6MVFFF beam from TrueBeam linear accelerator using PRIMO, a Monte Carlo simulation software. The results showed high level of agreement between simulated and measured data, demonstrating the reliability of PRIMO in radiation therapy.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Zhang, Qiang Li, Xinguo Liu, Guosheng Shen, Zheng Li, Weiqiang Chen, Ruijun Niu, Zhongying Dai, Guoqing Xiao
Summary: The study validates the calculation accuracy of the newly-proposed double Gaussian-logistic (DG-L) model in both homogeneous and heterogeneous phantoms, providing useful information for its future application in clinical carbon-ion treatment planning system.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Physics, Multidisciplinary
K. L. Zhang, Z. Song
Summary: The study reveals that applying a nonlocal non-Hermitian perturbation to an Ising chain merges the topological Kramer-like degeneracy in the ferromagnetic phase, with distinct dynamic responses for different quantum phases. The phase diagram at zero temperature is completely preserved at finite temperatures.
PHYSICAL REVIEW LETTERS
(2021)
Article
Multidisciplinary Sciences
Stefan Tessarini, Michael Karl Fix, Peter Manser, Werner Volken, Daniel Frei, Lorenzo Mercolli, Marco Stampanoni
Summary: This study proposes a new semi-classical MC algorithm for modeling scattering and interference processes simultaneously. By implementing it as an extension of EGSnrc, efficient system design and dose estimation for X-ray grating interferometry can be achieved. The feasibility of simulating interference effects is confirmed through experiments and comparison with conventional MC transport.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hannes A. Loebner, Werner Volken, Silvan Mueller, Jenny Bertholet, Paul-Henry Mackeprang, Gian Guyer, Daniel M. Aebersold, Marco F. M. Stampanoni, Peter Manser, Michael K. Fix
Summary: A flexible Monte Carlo-based robustness calculation and evaluation tool was developed to assess and quantify the dosimetric robustness of radiotherapy treatment plans. The tool enables calculation and evaluation of uncertainty scenarios to understand the impact of patient and machine-specific uncertainties on dose distribution.
Article
Engineering, Biomedical
S. Mueller, G. Guyer, T. Risse, S. Tessarini, D. M. Aebersold, M. F. M. Stampanoni, M. K. Fix, P. Manser
Summary: This study developed a hybrid algorithm for optimizing treatment plans and demonstrated its effectiveness in IMRT and MBRT. By improving aperture selection and allowing aperture shape changes, the algorithm achieves faster convergence to the objective function value.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Dominik Henzen, Daniel Schmidhalter, Gian Guyer, Anna Stenger-Weisser, Ekin Ermis, Robert Poel, Moritz Caspar Deml, Michael Karl Fix, Peter Manser, Daniel Matthias Aebersold, Hossein Hemmatazad
Summary: This study evaluated the feasibility of postoperative stereotactic body radiation therapy (SBRT) using CyberKnife for patients with hybrid implants consisting of carbon fiber reinforced polyetheretherketone and titanium (CFP-T). The results showed that with CFP-T implants, target volumes could be accurately delineated and dose calculation and delivery of SBRT were feasible.
RADIATION ONCOLOGY
(2022)
Article
Engineering, Biomedical
G. Guyer, S. Mueller, C. Koechli, D. Frei, W. Volken, J. Bertholet, P-H Mackeprang, H. A. Loebner, D. M. Aebersold, P. Manser, M. K. Fix
Summary: The study aims to develop a treatment planning process for non-isocentric DTRT and validate its dosimetric accuracy. By comparing three use cases, it is found that non-isocentric DTRT offers versatile benefits such as reducing collision risk, shortening delivery time, and improving dosimetric plan quality.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Jenny Bertholet, Paul-Henry Mackeprang, Silvan Mueller, Gian Guyer, Hannes A. Loebner, Yanick Wyss, Daniel Frei, Werner Volken, Olgun Elicin, Daniel M. Aebersold, Michael K. Fix, Peter Manser
Summary: This study provides a proof of principle of DTRT for common head and neck (HN) cancer cases and compares it to state-of-the-art VMAT. The results demonstrate that DTRT can achieve substantial organ-at-risk sparing.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Robert Poel, Elias Ruefenacht, Ekin Ermis, Michael Mueller, Michael K. Fix, Daniel M. Aebersold, Peter Manser, Mauricio Reyes
Summary: This study analyzed the impact of outliers in automatically segmented target structures on dose distribution, finding that outliers can increase dose to healthy brain tissue. The size, location and distance of outliers to the main target affect the extent of dose effect, with larger outliers further from the target having a higher potential dose impact.
RADIATION ONCOLOGY
(2022)
Article
Engineering, Biomedical
S. Mueller, G. Guyer, W. Volken, D. Frei, N. Torelli, D. M. Aebersold, P. Manser, M. K. Fix
Summary: The goal of this study is to improve the computational efficiency of a fully MC based treatment planning process for intensity modulated treatment plans. By implementing multiple methods and studying their parameters, the researchers were able to significantly reduce computation times without substantial degradation in final plan quality.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
M. K. Fix, D. Frei, S. Mueller, G. Guyer, H. A. Loebner, W. Volken, P. Manser
Summary: This study developed an auto-commissioning procedure for the MC beam model above the pMLC on a TrueBeam system with electron energies ranging from 6 to 22 MeV. The procedure relies on pre-determined information from MC simulations, in-air dose profiles, and absolute dose measurements in water. The results show that the auto-commissioning can be completed in a few minutes and the calculated and measured dose distributions are generally in good agreement.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hannes A. A. Loebner, Daniel Frauchiger, Silvan Mueller, Gian Guyer, Paul-Henry Mackeprang, Marco F. M. Stampanoni, Michael K. K. Fix, Peter Manser, Jenny Bertholet
Summary: This study aimed to experimentally assess the technical feasibility and quantify the mechanical and dosimetric accuracy of respiratory gating during Dynamic Trajectory Radiotherapy (DTRT) delivery. The results showed that gating can be successfully applied during DTRT delivery on a TrueBeam system, and it substantially improved the dosimetric performance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gian Guyer, Silvan Mueller, Yanick Wyss, Jenny Bertholet, Remo Schmid, Marco F. M. Stampanoni, Peter Manser, Michael K. Fix
Summary: This study develops a freely available collision prediction tool using Blender software, which accurately predicts possible collisions between the gantry, table, and patient in non-coplanar radiotherapy treatment. The tool is validated and found to have a high true positive rate and true negative rate. It allows for the calculation of collision-free zones and checking of treatment plans, providing visualizations of gantry and table movement.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hannes A. Loebner, Silvan Mueller, Werner Volken, Philipp Wallimann, Daniel M. Aebersold, Marco F. M. Stampanoni, Michael K. Fix, Peter Manser
Summary: This study comprehensively investigates the impact of gantry-table rotation gradient on the plan quality in dynamic trajectory radiotherapy (DTRT). It is found that increasing the gradient improves dosimetric plan quality but also prolongs delivery time.
Article
Engineering, Biomedical
Gian Guyer, Silvan Mueller, Paul-Henry Mackeprang, Daniel Frei, Werner Volken, Daniel M. Aebersold, Kristina Loessl, Peter Manser, Michael K. Fix
Summary: An effective treatment planning process (TPP) for Arc-MBRT was developed and showed the potential to improve plan quality while maintaining short delivery times compared to Static-MBRT. This has significance in integrating pMLC-based MBRT into clinical practice.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)