Article
Multidisciplinary Sciences
Hongchang Wang, Kawal Sawhney
Summary: Researchers have successfully generated omnidirectional differential phase images using X-ray differential phase contrast imaging, providing more information for studying complex samples and enabling simultaneous extraction of omnidirectional dark-field images to study ordered scattering structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Hongchang Wang, Kawal Sawhney
Summary: This article introduces a method for generating omnidirectional differential phase images by scanning a randomly structured modulator, which provides more information than traditional imaging methods and allows the simultaneous extraction of omnidirectional dark-field images for studying strongly ordered scattering structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Computer Science, Interdisciplinary Applications
A. Aminzadeh, B. D. Arhatari, A. Maksimenko, C. J. Hall, D. Hausermann, A. G. Peele, J. Fox, B. Kumar, Z. Prodanovic, M. Dimmock, D. Lockie, K. M. Pavlov, Y. Nesterets, D. Thompson, S. C. Mayo, D. M. Paganin, S. T. Taba, S. Lewis, P. C. Brennan, H. M. Quiney, T. E. Gureyev
Summary: In this study, a method to improve the detection of microcalcifications in breast tissues using propagation-based phase-contrast X-ray computed tomography was proposed. The results showed that the visibility of microcalcifications in the dark-field images was more than two times higher compared to the bright-field images, and the dark-field images provided more accurate information about the size and shape of the microcalcifications.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Uttam Pyakurel, Weiyuan Sun, Pikting Cheung, Desiree D'Moore, Xiaoyun Zhang, Carolyn A. MacDonald, Jonathan C. Petruccelli
Summary: This study developed a practical X-ray phase and dark-field imaging system using structured illumination with a wire mesh and polycapillary optics for coherence enhancement. Mesh-shifting algorithm and deblurring technique improved resolution and accuracy in phase and DF imaging. The system demonstrated significant potential for diagnostic imaging in a clinical setting.
Article
Chemistry, Multidisciplinary
Somayeh Saghamanesh, Henning Richter, Antonia Neels, Robert Zboray
Summary: This study proposes and evaluates the potential of a multi-modal X-ray imaging technique called speckle-based imaging (SBI) to differentiate between various types of urinary stones. The results show that SBI can provide detailed information about the composition of urinary stone types and can differentiate between them.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Matteo Busi, Jiazhou Shen, Michael Bacak, Marie Christine Zdora, Jan Capek, Jacopo Valsecchi, Markus Strobl
Summary: This study introduces a novel multi-directional neutron dark-field imaging approach that utilizes a single absorption grating to simultaneously probe multiple scattering directions. The method successfully resolves the microstructural properties of materials and overcomes limitations of conventional neutron dark-field imaging in assessing complex heterogeneous anisotropic microstructures.
SCIENTIFIC REPORTS
(2023)
Article
Computer Science, Interdisciplinary Applications
Manuel Viermetz, Nikolai Gustschin, Clemens Schmid, Jakob Haeusele, Bernhard Gleich, Bernhard Renger, Thomas Koehler, Franz Pfeiffer
Summary: X-ray computed tomography (CT) is an important imaging technique in clinical diagnostics. Dark-field CT, which provides additional microstructural information, has shown potential clinical value. In this paper, the performance of a prototype dark-field CT system is discussed, including the evaluation of the interferometer components and challenges related to integration into the CT gantry. The impact of the X-ray source and vibrations on the system are analyzed, and a beam hardening correction is introduced to enable quantitative dark-field imaging. The resolution and patient dose are also analyzed, and initial patient studies using the presented dark-field CT system are suggested.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Computer Science, Interdisciplinary Applications
Manuel Viermetz, Nikolai Gustschin, Clemens Schmid, Jakob Haeusele, Peter B. Noel, Roland Proksa, Stefan Loscher, Thomas Koehler, Franz Pfeiffer
Summary: Computed tomography (CT) is an important clinical diagnostics method, but its current limit to X-rays' attenuation contrast only can be expanded with dark-field imaging. Dark-field imaging offers access to more tissue properties, such as micro-structural texture or porosity. However, up-scaling this method to clinical scale is complex due to design constraints such as limited manufacturing technology and minimal modifications to the CT gantry. In this study, the advantages of an inverse interferometer and a triangular grating profile are discussed, making a compact and sensitive interferometer implementation feasible. The evaluation of the triangular grating profile reveals a deviation in the interference pattern compared to standard grating profiles, which must be taken into consideration in subsequent data processing.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Daisuke Shimao, Naoki Sunaguchi, Tetsuya Yuasa, Masami Ando, Kensaku Mori, Rajiv Gupta, Shu Ichihara
Summary: XDFI, with the use of a thin silicon crystal, allows visualization of three-dimensional morphological alterations of human tissue with high sensitivity and excellent resolution, generating 3D virtual histological images equivalent to stained histological sections without the need for contrast medium or staining.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jana Andrejewski, Fabio De Marco, Konstantin Willer, Wolfgang Noichl, Theresa Urban, Manuela Frank, Alex Gustschin, Pascal Meyer, Thomas Koehler, Franz Pfeiffer, Julia Herzen
Summary: X-ray dark-field imaging has been successfully used to retrieve 3D information for human thorax sized objects, with a method similar to classic tomography and tomosynthesis.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Dongfu Song, Yuliang Zhao, Yiwang Jia, Runxia Li, Nan Zhou, Kaihong Zheng, Yanan Fu, Weiwen Zhang
Summary: The effect of Mn addition on the formation and properties of Fe-rich phases in Al-7Si-1.2Fe alloys was systematically studied. The results show that Mn addition changes the morphology of the Fe-rich phase and increases the three-dimensional structure of the phase with increasing Mn content. Excessive Mn addition leads to the formation of large Fe-rich phases, resulting in a reduction in the elongation properties of the alloys.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Benedicta D. Arhatari, Andrew W. Stevenson, Darren Thompson, Adam Walsh, Tom Fiala, Gary Ruben, Nader Afshar, Sinem Ozbilgen, Tingting Feng, Stephen Mudie, Prithi Tissa
Summary: The Micro-Computed Tomography (MCT) beamline, the first one in the BRIGHT project, has been constructed at the Australian Synchrotron to provide higher spatial resolution imaging for smaller samples compared to the existing Imaging and Medical Beamline (IMBL). This beamline operates with an X-ray energy range from 8 to 40 keV using a bending magnet as the source. It offers various imaging modes including phase-contrast modalities and conventional absorption contrast, leveraging the unique properties of synchrotron radiation sources. The progress and imaging results of the MCT project in delivering high-spatial-resolution imaging will be presented in the paper.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Biomedical
Naoki Sunaguchi, Daisuke Shimao, Rieko Nishimura, Akari Iwakoshi, Tetsuya Yuasa, Masami Ando, Shu Ichihara
Summary: The study evaluated the relationship between the morphology of nipple ducts and the presence of cancer using X-ray dark-field imaging. It found a strong correlation between the presence of ductal carcinoma in situ and distended ducts with heterogeneous content. 3D microscale anatomy of nipple ducts revealed by XDFI-CT is useful in assessing the risk of breast cancer involvement in nipple-sparing mastectomy.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2021)
Article
Multidisciplinary Sciences
Ilian Haeggmark, Kian Shaker, Sven Nyren, Bariq Al-Amiry, Ehsan Abadi, William P. Segars, Ehsan Samei, Hans M. Hertz
Summary: Respiratory X-ray imaging enhanced by phase contrast has shown improved airway visualization in animal models, but limitations in current technology hinder its clinical translation, making its potential impact uncertain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Manuel Viermetz, Nikolai Gustschin, Clemens Schmid, Jakob Haeusele, Maximilian von Teuffenbach, Pascal Meyer, Frank Bergner, Tobias Lasser, Roland Proksa, Thomas Koehler, Franz Pfeiffer
Summary: X-ray computed tomography (CT) is a commonly used three-dimensional medical imaging technique. Dark-field imaging offers complementary information on tissue microstructure. However, translating dark-field CT to human scale has been a challenge. In this study, the integration of a Talbot-Lau interferometer into a clinical CT gantry enables successful dark-field CT imaging of a human-sized anthropomorphic body phantom.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Critical Care Medicine
Laura Maugeri, Aleksandar Jankovski, Emil Malucelli, Fabio Mangini, Jean-Michel Vandeweerd, Jacques Gilloteaux, Kathleen De Swert, Francesco Brun, Ginevra Begani Provinciali, Mauro DiNuzzo, Alberto Mittone, Alberto Bravin, Giuseppe Gigli, Federico Giove, Alessia Cedola, Charles Nicaise, Michela Fratini
Summary: A non-invasive imaging technique capable of capturing neuronal loss, vascular damage, and tissue reorganization following spinal cord injury (SCI) is currently lacking. In this study, a multi-modal approach combining synchrotron X-ray phase-contrast tomography (SXPCT), histology, and correlative methods was developed to study neurovascular architecture in SCI. SXPCT was able to capture neuronal loss and blood-brain barrier breakdown, providing high-resolution three-dimensional imaging of cellular changes.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Mechanics
Jesbeer Kallungal, Laurent Chazeau, Jean-Marc Chenal, Jerome Adrien, Eric Maire, Claire Barres, Bernard Cantaloube, Patrick Heuillet, Fabien Wilde, Julian Moosmann, Timm Weitkamp
Summary: This paper presents a precise 3D quantification of damage evolution and crack initiation in peroxide crosslinked EPDM filled with metallic oxide particles and filler agglomerates using synchrotron radiation X-ray Tomography. Polymer debonding is observed at the poles of metallic oxide particles during stretching, while crack always originates from carbon black agglomerates. The crack initiation process involves cavity nucleation, cavity growth, and eventual fracture of the agglomerates.
ENGINEERING FRACTURE MECHANICS
(2023)
Article
Optics
Hanna Dierks, Till Dreier, Robin Krueger, Martin Bech, Jesper Wallentin
Summary: Propagation-based phase contrast imaging with a laboratory x-ray source is useful for studying samples with low absorption contrast. Recent advances in X-ray lab sources allow for higher magnification and shorter source-sample distance, resulting in enhanced edge contrast. The optimal magnification for edge enhancement fringes depends on source size, sample feature steepness, and detector resolution. A stronger influence of sample feature on optimal magnification is observed in this high-magnification geometry.
Article
Radiology, Nuclear Medicine & Medical Imaging
Luca Fardin, Camilla Giaccaglia, Paolo Busca, Alberto Bravin
Summary: This study characterized the Eiger 2X CdTe 1 M-W detector for imaging applications using monochromatic synchrotron radiation. The results showed that the detector had linear response and detection efficiency higher than 60% within the specified photon flux range. The spatial resolution was found to be compatible with the pixel size of the detector, except at energies just above the K-edge of Cd and Te. The study also revealed a time-dependent response of the sensor, which was mitigated at low photon fluxes.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Multidisciplinary Sciences
Jan Stephan Bolten, Christine Tanner, Griffin Rodgers, Georg Schulz, Soledad Levano, Timm Weitkamp, Samuel Waldner, Ramya Deepthi Puligilla, Daniel Bodmer, Bert Mueller, Jorg Huwyler
Summary: Nephrotoxicity is an important factor to be assessed during drug discovery and development, and in vitro cell-based assays are commonly used for this purpose. However, translating the results of these assays to vertebrates, including humans, is challenging. In this study, we evaluated whether zebrafish larvae could serve as a screening model for detecting gentamicin-induced changes in the kidney. We compared the results of the zebrafish larvae with kidney biopsies from gentamicin-treated mice to validate the model.
Article
Engineering, Biomedical
Matthieu Chourrout, Christophe Sandt, Timm Weitkamp, Tanja Ducic, David Meyronet, Thierry Baron, Jan Klohs, Nicolas Rama, Herve Boutin, Shifali Singh, Cecile Olivier, Marlene Wiart, Emmanuel Brun, Sylvain Bohic, Fabien Chauveau
Summary: Synchrotron X-ray phase-contrast tomography (XPCT) can visualize amyloid-beta (A beta) plaques from Alzheimer's Disease (AD) in label-free brain samples. This study suggests that the contrast of A beta in XPCT may be caused by A beta fibrils and/or metals trapped in the plaques. Analysis of brain samples from different types of AD patients and AD models reveals that a hyperdense contrast formation of A beta plaques in XPCT images is associated with biometal entrapment within plaques.
ACTA BIOMATERIALIA
(2023)
Article
Agricultural Engineering
Delphine Quereilhac, Lola Pinsard, Elouan Guillou, Marina Fazzini, Emmanuel De Luycker, Alain Bourmaud, Marwa Abida, Jonathan Perrin, Timm Weitkamp, Pierre Ouagne
Summary: Flax fibres are valuable reinforcements for composites, but defects called kink-bands might affect their properties. This study investigates the pores within the kink-band using X-ray microtomography, revealing their organization and correlation with the fiber's ultrastructure. Local increase in porosity was found in severe defect zones along the fiber.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Physical
Alberta Terzi, Nunzia Gallo, Teresa Sibillano, Davide Altamura, Annalia Masi, Rocco Lassandro, Alessandro Sannino, Luca Salvatore, Oliver Bunk, Cinzia Giannini, Liberato De Caro
Summary: Type I collagen scaffold is widely used in tissue engineering and medical applications. The hierarchical structure and multiscale integrity of collagen from different animal sources were studied in relation to tissue-specific regeneration and scaffold design. The structural organization of collagen in tendons was investigated using X-ray scattering techniques and thermal and load-bearing tests.
Article
Physics, Applied
Ian Buchanan, Silvia Cipiccia, Carlo Peiffer, Carlos Navarrete-Leon, Alberto Astolfo, Tom Partridge, Michela Esposito, Luca Fardin, Alberto Bravin, Charlotte K. Hagen, Marco Endrizzi, Peter R. T. Munro, David Bate, Alessandro Olivo
Summary: X-ray dark-field or ultra-small angle scatter imaging is important in fields such as in vivo lung imaging and explosives detection, providing direct measurement of the scattering function. A new contrast mechanism, the variance of refraction, is introduced and is directly linked to the size of the scattering centers.
APPLIED PHYSICS REVIEWS
(2023)
Letter
Oncology
Carlo Morasso, Renzo Vanna, Francesca Piccotti, Lidia Frizzi, Marta Truffi, Sara Albasini, Camelia Borca, Thomas Huthwelker, Laura Villani, Oliver Bunk, Cinzia Giannini, Fabio Corsi
CANCER COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Oscar van der Have, Timothy J. Mead, Christian Westoo, Niccolo Peruzzi, Ayse C. Mutgan, Christian Norvik, Martin Bech, Andre Struglics, Konrad Hoetzenecker, Hans Brunnstrom, Gunilla Westergren-Thorsson, Grazyna Kwapiszewska, Suneel S. Apte, Karin Tran-Lundmark
Summary: Expansion of extracellular matrix, specifically aggrecan, occurs in all stages of pulmonary angiopathy associated with pulmonary arterial hypertension (PAH). Aggrecan accumulates in the pulmonary arteries of PAH patients and is localized to cellular lesions rather than fibrotic or collagenous lesions. The upregulation of the potential aggrecanase ADAMTS15 in PAH suggests dysregulation of aggrecan turnover is a response to altered hemodynamics. These findings support the potential therapeutic targeting of aggrecan and aggrecanase regulation in PAH.
PULMONARY CIRCULATION
(2023)
Article
Agricultural Engineering
Loren Morgillo, Lena Brionne, Alessia Melelli, Pierre Ouagne, Mario Scheel, Timm Weitkamp, Darshil U. Shah, Marwa Abida, Johnny Beaugrand, Alain Bourmaud
Summary: This study conducted an extensive multi-scale statistical analysis on flax fibres extracted from different batches processed with varying scutching and combing conditions. It found that the occurrence of kink-bands in the fibres is related to their mechanical properties, with uncombed fibres having more cortical residues and larger surface kink-bands. The results show that changes in kink-bands structure are responsible for the evolutions in mechanical behavior.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Xiaowen Liang, Icha Ben Zemzem, Sebastien Almagro, Jean-Charles Boisson, Luiz-Angelo Steffenel, Timm Weitkamp, Laurent Debelle, Nicolas Passat
Summary: This article presents a dedicated pipeline for the segmentation of micro CT images of mice aorta, combining conventional image processing paradigms and deep learning approaches to address the issue of multiscale analysis of large-sized, high-resolution data. The promising results of this method are evaluated by comparison with manually annotated data.
2022 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, ICIP
(2022)
Proceedings Paper
Optics
Griffin Rodgers, Christine Tanner, Georg Schulz, Timm Weitkamp, Mario Scheel, Marta Girona Alarcon, Vartan Kurtcuoglu, Bert Mueller
Summary: This article introduces the use of mosaic tiling to extend the imaged volume for mapping the three-dimensional cytoarchitecture of the entire mouse brain. The author also discusses the challenges in processing these large-scale datasets.
DEVELOPMENTS IN X-RAY TOMOGRAPHY XIV
(2022)
Proceedings Paper
Optics
Martin Bech
Summary: Multiple binary structures in the phase grating can be simulated to utilize Moire effects and achieve phase-contrast imaging without the use of attenuating grating structures.
DEVELOPMENTS IN X-RAY TOMOGRAPHY XIV
(2022)
