Article
Biology
Oana Belei, Diana-Georgiana Basaca, Elena Rodica Heredea, Emil Radu Iacob, Laura Olariu, Roxana Folescu, Andrei Gheorghe Marius Motoc, Anda-Maria Nanu, Otilia Marginean
Summary: VIPoma is a rare neuroendocrine tumor that produces vasoactive intestinal peptide (VIP). While rare in adults without pancreatic ailments, VIPoma originating in the pancreas is exceedingly uncommon in children. Instead, WDHA syndrome, characterized by watery diarrhea, hypokalemia, and achlorhydria, is more commonly associated with neurogenic tumors located in the retroperitoneum or mediastinum. Chronic diarrhea in infants is a prevalent issue that requires attention from pediatric gastroenterologists, and delays in diagnosis can lead to complications.
Article
Oncology
Mu-Xing Li, Alexandra G. Lopez-Aguiar, George Poultsides, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, Cliff Cho, Shishir K. Maithel, Xu-Feng Zhang, Timothy M. Pawlik
Summary: The study aimed to define surgical outcomes of patients with GEP-NEN G3. The results showed that patients with NEC had worse survival outcomes compared to patients with NET G3 among those who underwent surgical resection.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Sylvia L. Asa, Stefano La Rosa, Olca Basturk, Volkan Adsay, Marianna Minnetti, Ashley B. Grossman
Summary: Well-differentiated neuroendocrine tumors commonly occur in the gastrointestinal and pancreaticobiliary system, with molecular studies pointing to genetic mutations and involvement of epigenetic regulators. Treatment approaches focus on the neuroendocrine nature of the tumors and targeting specific alterations.
ENDOCRINE PATHOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvia Nicolini, Lisa Bodei, Alberto Bongiovanni, Maddalena Sansovini, Ilaria Grassi, Toni Ibrahim, Manuela Monti, Paola Caroli, Anna Sarnelli, Danila Diano, Valentina Di Iorio, Chiara Maria Grana, Corrado Cittanti, Federica Pieri, Stefano Severi, Giovanni Paganelli
Summary: The combination of Lu-177-DOTATATE with metronomic capecitabine shows promising efficacy and tolerability in patients with aggressive FDG-positive G1-G3 GEP-NETs, laying the groundwork for future randomized studies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Giuseppe Lamberti, Natalie Prinzi, Alberto Bongiovanni, Mariangela Torniai, Elisa Andrini, Dario de Biase, Deborah Malvi, Mirta Mosca, Rossana Berardi, Toni Ibrahim, Sara Pusceddu, Davide Campana
Summary: This study investigated the molecular features and treatment response of grade 3 gastro-entero-pancreatic neuroendocrine tumors (G3 GEP-NET). The findings showed that FOLFOX/XELOX chemotherapy is effective as a first-line treatment for G3 GEP-NET. The mutational landscape of G3 NET is more similar to well-differentiated NETs.
Review
Oncology
Akira Ooki, Hiroki Osumi, Koshiro Fukuda, Kensei Yamaguchi
Summary: Neuroendocrine neoplasms (NENs) with neuroendocrine differentiation can occur in various organs. They are divided into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs), each with distinct etiology, molecular profile, and clinicopathological features. While most NECs originate in the lungs, extrapulmonary NECs are mostly found in the gastro-entero-pancreatic (GEP) system. There is an urgent need for effective therapeutic agents as platinum-based chemotherapy has limited clinical benefits and poor prognosis. The rarity and lack of knowledge about GEP-NECs have hindered the development of molecular-targeted therapies. This review summarizes the biology, current treatments, and molecular profiles of GEP-NECs based on comprehensive molecular analyses and identifies potential therapeutic targets for future precision medicine based on recent clinical trial results.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Surgery
Andrew H. Nguyen, Michael P. O'Leary, James P. De Andrade, Philip G. Ituarte, Susanne G. Warner, Laleh G. Melstrom, Jonathan Kessler, Yuman Fong, Daneng Li, Gagandeep Singh
Summary: This population-based study examines the clinical and pathological characteristics of the youngest 5% of adult GEP-NETs patients. The findings suggest that young patients tend to have localized, well differentiated tumors and that early stage and surgical intervention are associated with lower mortality risk.
AMERICAN JOURNAL OF SURGERY
(2022)
Review
Medicine, General & Internal
Francesco Panzuto, Claudio Ricci, Maria Rinzivillo, Ludovica Magi, Matteo Marasco, Giuseppe Lamberti, Riccardo Casadei, Davide Campana
Summary: This study evaluated the antiproliferative activity of a high dose of somatostatin analogs (HD-SSA) in treating gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) through a systematic review and proportion meta-analysis. The results showed that the incidence density ratio (IDR) of new progressions was 62% per year in patients treated with HD-SSA. Furthermore, the study found that HD-SSA had a significantly better effect in studies conducted in the USA, while its efficacy was lower in studies with a high proportion of metastatic patients. Therefore, HD-SSA can be considered as a therapeutic approach in selected cases when other antiproliferative treatments are not feasible.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Georgios Z. Papadakis, Apostolos H. Karantanas, Kostas Marias, Corina Millo
Summary: GEP-NETs are rare tumors with increasing incidence, requiring accurate localization and staging for personalized treatment strategies. Hybrid PET/CT imaging techniques play a crucial role in addressing this challenge.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Oncology
Gabriela Poltorak-Szymczak, Tadeusz Budlewski, Mariusz Ireneusz Furmanek, Waldemar Wierzba, Katarzyna Sklinda, Jerzy Walecki, Bartosz Mruk
Summary: This article discusses the importance of radiologic imaging in the diagnosis of neuroendocrine neoplasms, emphasizing the strengths and limitations of different imaging modalities.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Claudio Ricci, Giuseppe Lamberti, Carlo Ingaldi, Cristina Mosconi, Nico Pagano, Laura Alberici, Valentina Ambrosini, Lisa Manuzzi, Fabio Monari, Deborah Malvi, Francesca Rosini, Francesco Minni, Davide Campana, Riccardo Casadei
Summary: SSAs alone remain the best choice for treating well-differentiated GEP-NENs, while Lu-177-Dotatate plus SSA is a valid alternative for midgut NENs.
Article
Endocrinology & Metabolism
Simon Veedfald, Jens F. Rehfeld, Gerrit van Hall, Lars B. Svendsen, Jens J. Holst
Summary: The study investigated the rapid entero-pancreatic hormone secretion after nutrient ingestion and its correlation with gastric emptying and glucose absorption. Findings showed characteristic differences in timing and amplitude of early postprandial hormone responses, emphasizing the need to consider individual variations when interpreting mean responses and designing study protocols.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Sun Young Jeong, Young Suk Park, Jeeyun Lee, Jaeyeon Jang, Youngkyung Jeon, Ye Ji Jung, Daeho Choi, Joohyun Hong, Seung Tae Kim
Summary: This study analyzed the TMB and MSI markers in 31 patients with GEP-NENs and found that despite their low incidence, some GEP-NENs have high TMB. Therefore, MSI and TMB testing is necessary for precision medicine in this tumor type.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Oncology
Sun Young Jeong, Young Suk Park, Jeeyun Lee, Jaeyeon Jang, Youngkyung Jeon, Ye Ji Jung, Daeho Choi, Joohyun Hong, Seung Tae Kim
Summary: This study analyzed 31 cases of gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). The results showed that despite the low incidence, some patients had high TMB, indicating the need for MSI and TMB testing for this type of tumor.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Roberta Elisa Rossi, Alessandra Elvevi, Camilla Gallo, Andrea Palermo, Pietro Invernizzi, Sara Massironi
Summary: Endoscopy, especially endoscopic ultrasonography, plays a key role in the diagnosis and treatment of GEP-NENs. While EUS is the gold standard for pancreatic NENs, advanced techniques like video capsule endoscopy and double-balloon enteroscopy have improved the diagnosis of small bowel NENs. Therapeutically, endoscopic removal is preferred for certain types of NENs, with EUS-guided pancreatic locoregional ablative treatments showing promising results in controlling symptoms.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Suchismita Dutta, Andrew Lai, Katherin Scholz-Romero, Muhammad J. A. Shiddiky, Yusuke Yamauchi, Jay S. Mishra, Gregory E. Rice, Jon Hyett, Sathish Kumar, Carlos Salomon
Article
Biochemistry & Molecular Biology
Laura B. James-Allan, Frederick J. Rosario, Kelsey Barner, Andrew Lai, Dominic Guanzon, H. David McIntyre, Martha Lappas, Theresa L. Powell, Carlos Salomon, Thomas Jansson
Article
Biochemistry & Molecular Biology
Pingping Han, Peter Mark Bartold, Carlos Salomon, Saso Ivanovski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Nanoscience & Nanotechnology
Mona Alharbi, Shayna Sharma, Dominic Guanzon, Andrew Lai, Felipe Zuniga, Muhammad J. A. Shiddiky, Yusuke Yamauchi, Alexis Salas-Burgos, Yaowu He, Tanja Pejovic, Carmen Winters, Terry Morgan, Lewis Perrin, John D. Hooper, Carlos Salomon
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Oncology
Narshone Soda, Muhammad Umer, Navid Kashaninejad, Surasak Kasetsirikul, Richard Kline, Carlos Salomon, Nam-Trung Nguyen, Muhammad J. A. Shiddiky
Article
Biochemistry & Molecular Biology
Olivia Ruhen, Bob Mirzai, Michael E. Clark, Bella Nguyen, Carlos Salomon, Wendy Erber, Katie Meehan
Summary: Increasing recognition of ctDNA as a non-invasive alternative for molecular characterisation and disease monitoring. Limited research on the relationship between EV DNA and ctDNA, with ctDNA showing greater sensitivity in monitoring breast cancer progression.
Article
Biochemistry & Molecular Biology
Pingping Han, Peter Mark Bartold, Carlos Salomon, Saso Ivanovski
Summary: The study compared salivary sEVs from periodontitis patients, healthy controls, and gingivitis patients, finding that global 5mC hypermethylation in salivary sEVs can serve as a potential biomarker with high sensitivity and specificity for distinguishing periodontitis patients. Periodontitis sEVs showed significantly increased levels of LPS+ OMVs, global 5mC methylation, and periodontal pathogens, which were more pronounced in sEVs than whole saliva.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Mona Alharbi, Andrew Lai, Shayna Sharma, Priyakshi Kalita-de Croft, Nihar Godbole, America Campos, Dominic Guanzon, Alexis Salas-Burgos, Flavio Carrion, Felipe A. Zuniga, Lewis Perrin, Yaowu He, Tanja Pejovic, Carmen Winters, Terry Morgan, John D. Hooper, Gregory E. Rice, Carlos Salomon
Summary: Ovarian cancer is one of the most lethal cancers worldwide affecting women, with non-specific early symptoms. sEVs produced under low oxygen tension can induce a metabolic switch in ovarian cancer cells, promoting resistance to carboplatin. The presence of glycolysis pathway proteins in sEVs is closely associated with ovarian cancer recurrence.
Review
Oncology
America Campos, Shayna Sharma, Andreas Obermair, Carlos Salomon
Summary: The article discusses the association between miRNAs within extracellular vesicles (EVs) and chemotherapy resistance, identifying certain miRNAs in various cancers linked to chemoresistance. Studies suggest that miR-21, miR-222, and miR-155 have roles in response to chemotherapy in different types of tumors.
Article
Oncology
Narshone Soda, Zennia Jean Gonzaga, Amandeep Singh Pannu, Navid Kashaninejad, Richard Kline, Carlos Salomon, Nam-Trung Nguyen, Prashant Sonar, Bernd H. A. Rehm, Muhammad J. A. Shiddiky
Summary: Genomic profiling of cancer-derived materials in circulation is an important approach for tumor genotyping, enabling enhanced cancer screening, early diagnosis, and therapy response evaluation. The development of a multifaceted technology platform based on bioengineered polymer nanobeads allows for efficient capture and electrochemical detection of DNA methylation in ovarian cancer patient samples. This versatile diagnostic platform can be used for detecting various disease biomarkers and multiple disease diagnoses.
Review
Cell Biology
Priyakshi Kalita-de Croft, Shayna Sharma, Nihar Godbole, Gregory E. Rice, Carlos Salomon
Summary: Ovarian cancer is one of the most diagnosed gynecological cancers in women, often diagnosed at an advanced stage due to the lack of effective early screening. Extracellular vesicles play a crucial role in the tumor microenvironment of ovarian cancer, with potential applications in diagnosis, delivery of therapeutic agents, and disease monitoring.
Article
Oncology
Kekoolani S. Visan, Richard J. Lobb, Shu Wen Wen, Justin Bedo, Luize G. Lima, Sophie Krumeich, Carlos Palma, Kaltin Ferguson, Ben Green, Colleen Niland, Nicole Cloonan, Peter T. Simpson, Amy E. McCart Reed, Sarah J. Everitt, Michael P. MacManus, Gunter Hartel, Carlos Salomon, Sunil R. Lakhani, David Fielding, Andreas Moeller
Summary: Lung cancer is a leading cause of cancer-related death worldwide and has low survival rates due to lack of early detection. A study on a lung cancer biomarker based on a simple blood test shows promising advantages for diagnostic assessment. The study identifies a specific micro-RNA, miR-3182, as a potential biomarker for lung cancer diagnosis that can be detected in the blood.
Article
Biochemistry & Molecular Biology
Carlos Palma, H. David McIntyre, Carlos Salomon
Summary: Research on extracellular vesicles (EVs) has provided insights into physiological and pathophysiological conditions, particularly during pregnancy. Gestational diabetes mellitus (GDM) is a common and influential complication that affects the miRNAs and proteins within EVs, leading to metabolic changes.
Article
Biochemistry & Molecular Biology
Olivia Ruhen, Xinyu Qu, M. Fairuz B. Jamaluddin, Carlos Salomon, Aesha Gandhi, Michael Millward, Brett Nixon, Matthew D. Dun, Katie Meehan
Summary: This study aimed to quantitatively profile the proteomes of EVs isolated from blood samples of metastatic breast cancer patients to identify proteins associated with treatment response.
Article
Chemistry, Analytical
Kimberley Clack, Narshone Soda, Surasak Kasetsirikul, Richard Kline, Carlos Salomon, Muhammad J. A. Shiddiky
Summary: In this study, we developed a novel and rapid method to detect HOTAIR sequences. The method showed high specificity and sensitivity in clinical samples, making it a potential tool for ovarian cancer diagnosis.
