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Multidisciplinary Sciences
Yan-Peng Li, Dilare Adi, Ying-Hong Wang, Yong-Tao Wang, Xiao-Lei Li, Zhen-Yan Fu, Fen Liu, Aibibanmu Aizezi, Jialin Abuzhalihan, Mintao Gai, Xiang Ma, Xiao-mei Li, Xiang Xie, YiTong Ma
Summary: This study investigated the effects of genetic variants of the Dab2 gene on the risk of type 2 diabetes mellitus (T2DM) in the Uygur and Han populations of Xinjiang, China. The results showed that the variations in the Dab2 gene loci rs2255280 and rs2855512 were associated with the incidence of T2DM in the Uygur population, but not in the Han population. These variations were independent predictors for T2DM in the Uygur population.
Article
Multidisciplinary Sciences
Zahra Kavian, Saman Sargazi, Mahdi Majidpour, Mohammad Sarhadi, Ramin Saravani, Mansour Shahraki, Shekoufeh Mirinejad, Milad Heidari Nia, Maryam Piri
Summary: This study investigated the association between SLC11A1 gene polymorphisms and Type 2 Diabetes Mellitus (T2DM). The results showed that rs3731864 G/A and rs17235416 + TGTG/- TGTG had a negative association with T2DM and provided protection against the disease, while rs3731865 G/C was associated with an increased risk of T2DM. Additionally, SLC11A1-rs3731864 G/A was significantly associated with triglyceride levels in T2DM patients.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Minako Imamura, Atsushi Takahashi, Masatoshi Matsunami, Momoko Horikoshi, Minoru Iwata, Shin-Ichi Araki, Masao Toyoda, Gayatri Susarla, Jeeyun Ahn, Kyu Hyung Park, Jinhwa Kong, Sanghoon Moon, Lucia Sobrin, Toshimasa Yamauchi, Kazuyuki Tobe, Hiroshi Maegawa, Takashi Kadowaki, Shiro Maeda
Summary: The study identified two novel susceptibility SNP loci, STT3B and PALM2, and a novel gene, EHD3, that are associated with diabetic retinopathy in Japanese patients with type 2 diabetes. However, further replication studies are needed to validate these associations.
HUMAN MOLECULAR GENETICS
(2021)
Article
Endocrinology & Metabolism
Na Wang, Qian Liu, Hui Liu, Xiao Cong, Hui Yang, Yang Yu, Yongtong Cao, Liang Ma
Summary: The study revealed that Chinese T2DM patients with the epsilon 2/epsilon 3 genotype have an increased risk of developing IS. Additionally, high systolic blood pressure and a history of hypertension are independent risk factors for IS in T2DM patients.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Genetics & Heredity
Maria Trapali, Dimitra Houhoula, Anthimia Batrinou, Anastasia Kanellou, Irini F. Strati, Argyris Siatelis, Panagiotis Halvatsiotis
Summary: The present study found that the TNF-alpha- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms are associated with the risk of developing type 2 diabetes mellitus (T2DM).
Article
Endocrinology & Metabolism
Zaihan Zhu, Yanfen Zhang, Ruocen Bai, Ru Yang, Zhongyan Shan, Chunyan Ma, Jun Yang, Dandan Sun
Summary: This study found that miRNA polymorphisms involved in the insulin signaling pathways and the interaction effects of SNP-SNP, SNP-environmental factors were related to T2DM susceptibility in a Chinese population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Lei Wu, Yan Zhang, Hong Zhao, Guodong Rong, Peijun Huang, Fang Wang, Ting Xu
Summary: This study found that APOE gene polymorphisms are associated with CAD with or without T2DM and have an influence on lipid profiles in both T2DM and CAD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medical Laboratory Technology
Wen-Jing Zhang, Jiang-Hua Cheng, Zheng-Chao Nie, Bang-Sheng Ding, Zhong Han, Wei-Wei Zheng
Summary: The study revealed the association of E-selectin gene +A561C polymorphism with type 2 diabetes in the Chinese population, suggesting that the C allele and soluble E-selectin may be predisposing factors for individuals with type 2 diabetes in China.
CLINICAL LABORATORY
(2022)
Article
Genetics & Heredity
Ines Cilensek, Valentina Lapuh, Mojca Globocnik Petrovic, Daniel Petrovic
Summary: The study found a significant association between the T allele of rs11984041 in the HDAC9 gene and diabetic retinopathy in patients with type 2 diabetes mellitus, suggesting its potential role as a genetic risk factor for this complication.
Article
Endocrinology & Metabolism
Wei-Wei Chang, Li-Ying Wen, Liu Zhang, Xin Tong, Yue-Long Jin, Gui-Mei Chen
Summary: This study investigated the relationship between the miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in the Chinese Han population and conducted a meta-analysis. The results showed that the miR-146a rs2910164 polymorphism was associated with the risk of T2DM in certain age and BMI subgroups, but no significant association was found in the overall meta-analysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Nada Alqadri
Summary: This study investigated the genotyping levels of rs5210 polymorphism in the KCNJ11 gene in the older population with T2DM in Saudi Arabia. The results showed an association between the rs5210 polymorphism and allele frequencies. However, further large-scale studies are needed to determine whether KCNJ11 gene polymorphisms may serve as risk markers for T2DM in the Saudi population.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kamel Mohammedi, Yawa Abouleka, Charlyne Carpentier, Louis Potier, Severine Dubois, Ninon Foussard, Vincent Rigalleau, Jean-Francois Gautier, Pierre Gourdy, Guillaume Charpentier, Ronan Roussel, Andre Scheen, Bernard Bauduceau, Samy Hadjadj, Francois Alhenc-Gelas, Michel Marre, Gilberto Velho
Summary: This study identified a potential association between the ACE gene's D allele and plasma ACE concentration with increased risk of lower-limb amputation in patients with type 1 diabetes, particularly minor amputations.
Article
Endocrinology & Metabolism
Kamel Mohammedi, Yawa Abouleka, Charlyne Carpentier, Louis Potier, Severine Dubois, Ninon Foussard, Vincent Rigalleau, Jean-Francois Gautier, Pierre Gourdy, Guillaume Charpentier, Ronan Roussel, Andre Scheen, Bernard Bauduceau, Samy Hadjadj, Francois Alhenc-Gelas, Michel Marre, Gilberto Velho
Summary: This study is the first to find an independent association between the ACE D allele and increased risk of LLA, mainly minor amputations, in patients with type 1 diabetes.
Article
Endocrinology & Metabolism
Fei Luo, Mingjie Shi, Junhao Guo, Yisen Cheng, Xusan Xu, Jieqing Zeng, Si Huang, Weijun Huang, Wenfeng Wei, Yajun Wang, Riling Chen, Guoda Ma
Summary: A meta-analysis found no significant association between RETN -420C/G polymorphism and T2DM susceptibility. However, there was high heterogeneity across studies, which may be attributed to variations in age among participants.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Summary: Diabetes is a highly heterogeneous metabolic disease with different types and clinical manifestations. Distinguishing between types and defining subtypes is a major challenge in precise treatment. T2D is the main type of diabetes, and certain gene variants have been shown to increase the risk of T2D. HNF1 alpha gene mutations can cause different types of diabetes and exhibit high polymorphism.
FRONTIERS IN ENDOCRINOLOGY
(2022)