Article
Multidisciplinary Sciences
Luiz Guilherme Azevedo de Freitas, David Leonardo Cruvinel Isaac, Murilo Batista Abud, Alexandre Dantas Soares Quintas Segundo, Mariana Larissa Alvino Barros, Gabriela Caroline Monteiro de Albuquerque, Bruna Dantas Aires Guimaraes, Clarice Neuenschwander Lins de Morais, Marcos Pereira de Avila
Summary: This study aimed to analyze the concentrations of various cytokines in the aqueous humor of patients with diabetic macular edema and found significant changes in IL-6 and IL-8 levels during ranibizumab treatment, with VEGF showing a significant decrease at the end of the study. TNF, IL-1, IL-10, and IL-12 levels remained practically unchanged throughout the treatment process.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Zhikun Yang, Yu Di, Junjie Ye, Weihong Yu, Zijian Guo
Summary: The purpose of this study was to evaluate the optimal timing of intravitreal conbercept (IVC) treatment before pars plana vitrectomy (PPV) in patients with severe proliferative diabetic retinopathy (PDR). The study found that IVC treatment administered 7 days prior to surgery had better effectiveness and lower vitreous VEGF concentration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Kei Takayama, Hideaki Someya, Hiroshi Yokoyama, Takeshi Kimura, Yoshihiro Takamura, Masakazu Morioka, Hiroto Terasaki, Tetsuo Ueda, Nahoko Ogata, Shigehiko Kitano, Maki Tashiro, Taiji Sakamoto, Masaru Takeuchi
Summary: In this study, younger age and the presence of neovascular glaucoma and tractional retinal detachment were identified as potential biases in using IVI before vitrectomy for PDR complications. Eyes that received preoperative IVI had a higher frequency of intraoperative retinal breaks requiring tamponade, but there were no significant differences in postoperative outcomes compared to eyes that did not receive IVI.
Article
Medicine, General & Internal
Li Chen, Jing Feng, Yanhong Shi, Fuxiao Luan, Fang Ma, Yingjie Wang, Weiqiang Yang, Yong Tao
Summary: In patients with proliferative diabetic retinopathy, intravitreal ranibizumab (IVR) injection significantly reduced EPO levels but did not reach normal levels; there was no significant difference in VEGF levels between the IVR group and the control group. The expressions of EPO and VEGF were significantly reduced in the IVR group compared to the Non-IVR group in fluorescence immunostaining.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Nada O. Taher, Abdullah A. Ghaddaf, Sarah A. Al-Ghamdi, Jumanah J. Homsi, Bandar J. Al-Harbi, Lugean K. Alomari, Hashem S. Almarzouki
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of anti-VEGF monotherapy for retinopathy of prematurity (ROP). The results showed that anti-VEGF monotherapy had fewer adverse events compared to laser therapy, with no significant differences in other outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Cho-Yi Huang, Hsin-Chung Huang, Mei-Huei Chen, Tso-Ting Lai, Hung-Chieh Chou, Chien-Yi Chen, Ting -An Yen, Wellington Cardoso, Po-Nien Tsao
Summary: This study retrospectively evaluated the respiratory outcomes of preterm infants with bronchopulmonary dysplasia who received intravitreal bevacizumab (IVB) treatment. The results showed that IVB was significantly associated with prolonged ventilatory support and a lower likelihood of being ventilator free.
Article
Multidisciplinary Sciences
Eun Hee Hong, Hoseok Yeom, Hyo Seon Yu, Jong Eun Park, Yong Un Shin, So-Young Bang, Heeyoon Cho
Summary: This study analyzed the association between the genetic profile of patients with diabetic macular edema (DME) and their response to intravitreal anti-VEGF injection. Several genes were found to be associated with treatment response, including DIRC3, SLCO3A1, and RAB2A. Pathway analysis revealed a connection between RAB2A and CREB5 with AMPK signaling related to VEGF. These genetic biomarkers can provide insights into patient response and guide therapeutic strategies.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Dean F. Loporchio, Emily K. Tam, Jane Cho, Jaeyoon Chung, Gyungah R. Jun, Weiming Xia, Marissa G. Fiorello, Nicole H. Siegel, Steven Ness, Thor D. Stein, Manju L. Subramanian
Summary: This study compared the vitreous cytokine profiles of patients with proliferative diabetic retinopathy (PDR) to those without PDR. Novel increases in IL-15 and IL-16, along with expected VEGF, were observed in the vitreous humor of patients with PDR. Additionally, elevations of ICAM-1, VCAM-1, SAA, IL-8, and CRP were confirmed in the vitreous of PDR patients, as previously described.
Article
Multidisciplinary Sciences
Martin Hein, Aleksandar Vukmirovic, Ian J. Constable, Vignesh Raja, Arman Athwal, K. Bailey Freund, Chandrakumar Balaratnasingam
Summary: This study aims to identify biomarkers that predict improvement in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) in eyes with diabetic macular edema (DME) treated with intravitreal aflibercept. The study found that glycosylated hemoglobin, renal function, dyslipidemia, hypertension, cardiovascular disease and smoking were associated with treatment response. Baseline imaging, systemic and demographic variables showed associations with BCVA and CRT change post aflibercept. Predictors of BCVA improvement included macular vessel density and LDL level, while predictors of CRT reduction included peripheral non-perfusion and LDL level. These results may help better-select patients who will benefit from intravitreal aflibercept for DME treatment.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Jianqiang Lin, Kaixuan Cui, Yue Xu, Xiaoyu Tang, Yuxun Shi, Xi Lu, Boyu Yang, Qingjing He, Shanshan Yu, Xiaoling Liang
Summary: The study found that CD146 is involved in retinal neovascularization via the VEGFR2 pathway. Anti-CD146 may provide a new direction for the treatment of PDR and other ocular neovascular diseases.
ACTA OPHTHALMOLOGICA
(2022)
Review
Biotechnology & Applied Microbiology
Gunay Uludag, Muhammad Hassan, Wataru Matsumiya, Brandon Huy Pham, Sophaktra Chea, Ngoc Trong Tuong Than, Hien Luong Doan, Amir Akhavanrezayat, Muhammad Sohail Halim, Diana Do, Quan Dong Nguyen
Summary: Clinical trials have shown that intravitreal bevacizumab, ranibizumab, and aflibercept injections provide positive outcomes in terms of function and structure for patients with DME. These anti-VEGF agents also offer significant improvement in the severity of DR. New anti-VEGF agents such as brolucizumab, faricimab, and KSI-301 show promising results for the treatment of DME and potentially DR.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2022)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Medicine, General & Internal
Andreas Stahl, Emine A. Sukgen, Wei-Chi Wu, Domenico Lepore, Hidehiko Nakanishi, Jan Mazela, Darius M. Moshfeghi, Robert Vitti, Aditya Athanikar, Karen Chu, Pablo Iveli, Fei Zhao, Thomas Schmelter, Sergio Leal, Evra Kofuncu, Noriyuki Azuma
Summary: In infants with ROP, intravitreal aflibercept did not meet the criteria for noninferiority compared to laser photocoagulation in terms of treatment success at week 24. Rescue treatment was less required in the intravitreal aflibercept group, but the serious adverse event rates were higher in the laser photocoagulation group. Further data would be needed for more definitive conclusions on the comparative effects of these treatments.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Medicine, General & Internal
Yuxian Lin, Xiaowei Zheng, Qiujie Chen, Ruibin Wu
Summary: This study aims to evaluate the clinical efficacy of anti-VEGF therapy versus PRP for patients with PDR through a meta-analysis, providing a reliable theoretical basis for future research.
Article
Health Care Sciences & Services
Eugene Yu-Chuan Kang, Tzu-Yi Lin, Sunir J. Garg, Nan-Kai Wang, Lee-Jen Chen, Pei-Wei Huang, Ming-Jen Chan, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Yih-Shiou Hwang
Summary: This retrospective cohort study evaluated the systemic effects of three commonly used anti-vascular endothelial growth factor (VEGF) intravitreal injections in diabetes patients in Taiwan. The study found that different drugs (bevacizumab, ranibizumab, and aflibercept) had varying incidence rates of adverse events, such as ischemic stroke, major adverse lower-limb events, major bleeding, all-cause death, and all-cause admission. The study suggests that these differences may be attributed to drug variations and patient characteristics.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Hyun Goo Kang, Tae Young Kim, Min Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee
Summary: This study evaluated the clinical features and OCTA findings of MEWDS patients and found that some patients may develop overlapping MFC in the same or fellow eyes, with dynamic changes in choroidal thickness.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Jiwon Kim, Hyojin Seong, Kang Ju Son, Eun Jee Chung
Summary: The study investigated the age- and sex-specific annual incidence rates of patients treated for VTDR in T2DM patients in South Korea, finding a significant decrease in incidence rates over the study period. Factors such as insulin use, young age, chronic kidney disease, and male sex were associated with increased treatment rates for VTDR, while rural residents had a lower risk compared to metropolitan residents. Early diagnosis and appropriate treatment were key in reducing the incidence rate of VTDR in T2DM patients in South Korea.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biophysics
Ji Soo Choi, Dahye Yoon, Kyunghwa Han, Ja Seung Koo, Suhkmann Kim, Min Jung Kim
Summary: This study investigated the impact of tumor cell fraction on metabolic profiles assessed with HR-MAS MRS in breast cancers. The results showed that the variations in tumor cell fraction have limited effects on metabolite levels.
NMR IN BIOMEDICINE
(2022)
Article
Oncology
Jeea Lee, Ga Yoon Ku, Haemin Lee, Hyung Seok Park, Ja Seung Ku, Jee Ye Kim, Seho Park, Byeong-Woo Park
Summary: This study evaluated the rate of upgrade of lobular carcinoma in situ (LCIS) on preoperative biopsy to ductal carcinoma in situ (DCIS) or invasive carcinoma. The results showed a relatively high upgrade rate, and the presence of microcalcification and progesterone receptor expression may predict the upgrade. Surgical excision of LCIS during preoperative biopsy is recommended to identify any concealed malignancy.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Ophthalmology
Hyo Jin Seong, Jiwon Kim, Tae Mi Yook, Deokjong Lee, Eun Jee Chung
Summary: This study found that patients with visual impairment have an increased risk of depression from 3 years before to 5 years after registration. Significant risk factors for depression included severity of impairment, male sex, and younger age. Therefore, public mental health services that provide appropriate support and interventions for individuals before and after registration as visually impaired are necessary.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Hae Min Kang, Md Hasanuzzaman, So Won Kim, Hyoung Jun Koh, Sung Chul Lee
Summary: The aqueous endothelin-1 (ET-1) level is significantly higher in eyes with advanced diabetic retinopathy (DR) compared to those with early DR and control group. Moreover, the ET-1 level significantly reduces after intravitreal injections in patients with advanced DR.
Review
Biochemistry & Molecular Biology
Eunah Shin, Ja Seung Koo
Summary: Thyroid cancer is the most common cancer in the endocrine system. The tumor microenvironment (TME) of thyroid cancer involves cancer associated fibroblasts (CAF) and immune cells. CAF contribute to tumor progression through cell proliferation and extracellular matrix remodeling, while immune cells contribute through cell proliferation, angiogenesis, epithelial-mesenchymal transition, and immune suppression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hye Min Kim, Ja Seung Koo
Summary: Patient morbidity and mortality are significantly increased in metastatic breast cancer. The metastasis process of breast cancer is very complicated and controlled by various factors. Autophagy is an important regulatory factor affecting metastasis in breast cancer, involving cell mobility, metabolic adaptation, tumor dormancy, and cancer stem cells. In this article, we discuss the effects of autophagy on breast cancer metastasis and evaluate the potential use of autophagy modulators for metastasis treatment.
Article
Biochemistry & Molecular Biology
Yoon Jin Cha, Ja Seung Koo
Summary: The study investigates the expression of EMP 1, 2, and 3 in adrenal gland neoplasms and explores their broader implications. Immunohistochemical staining of tissue microarrays shows higher expression of EMP 3 in pheochromocytoma compared to adrenal cortical neoplasms, and higher expression of EMP 1 and EMP 3 in adrenal cortical carcinomas compared to adrenal cortical adenomas. High levels of EMP 1 and EMP 3 expression in adrenal cortical neoplasms are associated with shorter overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eun Kyung Kim, Ja Seung Koo
Summary: We investigated the expression of amine oxidase family proteins in adrenal gland neoplasm and found differences in expression between adrenal cortical neoplasm and pheochromocytoma, as well as between benign and malignant cells.
Review
Cell Biology
Eunah Shin, Ja Seung Koo
Summary: This review discusses clinicopathological factors, immunohistochemical markers, and molecular factors that have been investigated in previous studies to have an impact on the clinical prognosis of Phyllodes tumor.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Article
Oncology
Hyang Joo Ryu, Ja Seung Koo
Summary: This study investigated the expression of glucose and glutamine metabolism-related proteins in breast ductal carcinoma in situ (DCIS) and found that it is associated with molecular subtypes and stromal features.
Article
Ophthalmology
Ji Hwan Lee, Hee Suk Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee
Summary: Endogenous Klebsiella pneumoniae endophthalmitis (EKE) usually has a poor visual prognosis, and early diagnosis with fair initial visual acuity would be crucial in saving vision.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Oncology
Min Jhi Kim, Daham Kim, Ja Seung Koo, Ju Hee Lee, Kee-Hyun Nam
Summary: This study evaluated the association between vitamin D receptor and serum vitamin D levels in papillary thyroid cancer. The results showed increased expression of vitamin D receptor protein and mRNA in papillary thyroid cancer. Decreased vitamin D receptor expression was correlated with advanced stage cancer and low p21 protein expression. Lower vitamin D receptor mRNA expression was associated with low serum 25-hydroxyvitamin D level.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Cell Biology
Eun Kyung Kim, Ja Seung Koo
Summary: This study investigated the expression of epithelial membrane proteins in thyroid cancer and found that their expression varies according to the subtypes of thyroid cancer. Further research is needed to determine the role of these proteins as prognostic markers and treatment targets in thyroid cancer.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
