Article
Infectious Diseases
Andrew R. Dentino, DongHwa Lee, Kelley Dentino, Arndt Guentsch, Mohammadreza Tahriri
Summary: The study showed that as the density of phosphate in polymers increased, the metabolism of biofilms decreased. Loading CPC on phosphate disks significantly reduced biofilm metabolism, while a salivary pellicle only enhanced the antimicrobial activity of CPC on uncharged PMMA surfaces.
Article
Microbiology
Pratibha Sharma, Mehak Chaudhary, Garima Khanna, Praveen Rishi, Indu Pal Kaur
Summary: Histatin 5 (Hstn 5), an antimicrobial peptide found in saliva, exhibits fungicidal activity against various fungi and shows potential as a novel approach for controlling fungal infections.
Article
Biophysics
Nicholas G. Fischer, Conrado Aparicio
Summary: This article provides an overview of salivary pellicle formation processes and its impacts on dental biomaterials, discussing measurement techniques and factors that may affect its formation. Future research may lead to rationally designed dental biomaterials to control the salivary pellicle and enhance material function and patient outcomes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Microbiology
Jian Miao, Jessica Regan, Chun Cai, Glen E. Palmer, David L. Williams, Michael D. Kruppa, Brian M. Peters
Summary: This study characterizes the glycogen metabolism pathways in Candida albicans and shows that glycogen metabolism is important for the long-term survival and virulence of the fungus.
Article
Biochemistry & Molecular Biology
Markus Reise, Stefan Kranz, Markus Heyder, Julius Beck, Christian Roth, Andre Guellmar, Ferdinand von Eggeling, Ulrich Schubert, Bettina Loeffler, Bernd Sigusch, Marek M. Kowalczuk
Summary: The study investigated the proteomic profile of salivary pellicles formed on different dental composites, revealing that pellicle formation was material- and time-dependent, with differences in proteins among the composites and controls.
Review
Infectious Diseases
Vasiliki Soulountsi, Theodoros Schizodimos, Serafeim Chrysovalantis Kotoulas
Summary: In recent decades, invasive candidiasis (IC) has become a significant cause of morbidity, mortality, and economic burden in the intensive care unit (ICU). The epidemiology of IC remains a difficult and unsolved puzzle for the literature. IC burden estimation is challenging due to various definitions and limitations in case-finding methodologies. Candidemia and intra-abdominal candidiasis (IAC) are the predominant types of IC in the ICU, with an increasing incidence of candidemia, particularly in elderly or immunosuppressed patients, and a shift towards non-albicans species worldwide.
Article
Chemistry, Analytical
Mozhgan Boroumand, Federica Iavarone, Barbara Manconi, Luisa Pieroni, Viviana Greco, Giovanni Vento, Chiara Tirone, Claudia Desiderio, Antonella Fiorita, Gavino Faa, Irene Messana, Tiziana Cabras, Alessandra Olianas, Massimo Castagnola
Summary: This study found higher activity of convertases and carboxypeptidases in the saliva of preterm newborns, suggesting their importance for fetal development. However, aminopeptidase activity was not active in preterm newborns and only became active months after normal delivery. Further studies are encouraged to characterize the specific substrates of these enzymes.
Article
Materials Science, Multidisciplinary
Xiao Yang, Feng Lou, Weihao Yuan, Wanyin Song, Yiyuan Xue, Duan Wang, Yuchen Guo, Xu Peng, Xinyuan Xu, Chuang Liu, Ruibo Zhao, Xiao Yangh, Xianlong Wang, Chunmei Ding, Liming Bian, Jianshu Li
Summary: Inhibiting bacterial growth on biomedical implants is clinically significant. This study presents a surface-immobilized multifunctional coating based on a hybrid peptide, which exhibits effective antimicrobial and antifouling properties without cytotoxicity. In vivo studies demonstrate the effectiveness of this coating in reducing subcutaneous infections.
APPLIED MATERIALS TODAY
(2022)
Review
Medicine, General & Internal
Chen-Xuan Wei, Michael Francis Burrow, Michael George Botelho, W. Keung Leung
Summary: Recent technological and analytical breakthroughs have enabled studies on small quantity, highly complex protein samples, such as salivary pellicle. Advances in mass spectrometry-based computational proteomics allow precise identification and quantification of complex protein samples, facilitating the determination of corresponding genes and cellular functions at the protein level through protein-protein interaction mapping. This has led to the breaking of barriers in research on small-quantity-complex-protein samples such as salivary pellicle.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Physical
Hannah Boyd, Juan F. Gonzalez-Martinez, Rebecca J. L. Welbourn, Philipp Gutfreund, Alexey Klechikov, Carolina Robertsson, Claes Wickstrom, Thomas Arnebrant, Robert Barker, Javier Sotres
Summary: The study found that salivary pellicles have a two-layer structure, and the change in ionic strength can affect this structure. Decreasing ionic strength leads to swelling of the outer layer and partial removal of the inner layer. The interaction between mucins and other pellicle components plays a crucial role in determining the structure of the pellicle.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Microbiology
Eunae Cho, YounJung Park, Ki-Yeol Kim, Dawool Han, Hyun Sil Kim, Jeong-Seung Kwon, Hyung-Joon Ahn
Summary: The study investigated the clinical relevance of Candida hyphae in non-pseudomembranous oral candidiasis, revealing significant differences in clinical factors among different hyphae groups. It suggested that low-grade hyphae infection might represent a subclinical state of OC, and identified a new subtype named MNSC.
Article
Microbiology
Vinicius Tatsuyuji Sakima, Yuliana Vega-Chacon, Paulo Sergio Cerri, Bhumika Shokeen, Renate Lux, Ewerton Garcia de Oliveira Mima
Summary: This study evaluated the induction of denture stomatitis (DS) using acrylic devices and Candida spp. in rats. The results showed that both Candida spp. and acrylic devices did not cause significant inflammation in immunocompetent rats, but the shift in microbiota may precede the manifestation of inflammation.
Article
Microbiology
Jessica S. Price, Melissa Fallon, Raquel Posso, Matthijs Backx, P. Lewis White
Summary: This study evaluated the performance of the commercially available OLM CandID real-time PCR in serum testing for invasive candidiasis (IC). The study found that CandID had excellent sensitivity and specificity, and when combined with (1-3)-beta-D-Glucan testing, it could accurately confirm or exclude IC.
Review
Pharmacology & Pharmacy
Gina P. Rodriguez-Castano, Frank Rosenau, Ludger Staendker, Carolina Firacative
Summary: Expanding the antifungal drug arsenal is crucial for treating Candida infections, which are increasing in prevalence and often resistant to existing treatments. This review provides a comprehensive summary of antimicrobial peptides (AMPs) with anti-Candida activity that have undergone successful preclinical or clinical trials. The source, mode of action, and animal model of infection or clinical trial for these AMPs are presented. The advantages of combination therapy using AMPs and other drugs to fight Candida infections are also discussed.
Review
Dentistry, Oral Surgery & Medicine
Romeo Patini, Gioele Gioco, Cosimo Rupe, Maria Contaldo, Rosario Serpico, Michele Giuliani, Carlo Lajolo
Summary: This study assessed the prevalence of oral colonization by Candida spp. in patients with psoriasis and the prevalence of oral lesions associated with Candida spp. It also identified the risk factors for oral lesions. The results showed that psoriatic patients had a higher risk of oral Candida colonization, especially those who received immunosuppressive therapies.
Article
Dentistry, Oral Surgery & Medicine
David Zuanazzi, Yizhi Xiao, Walter L. Siqueira
Summary: The study found that the composition of the salivary pellicle was more complex on rough surfaces (SLA and SLActive). Despite variation in protein composition between surfaces, most proteins were detected on more than one surface, indicating limited surface specificity for protein binding. The salivary pellicle formed on SLActive had a larger number of proteins associated with immune response, biological adhesion, and biomineralization.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Anatomy & Morphology
Christian Reis Lemes, Carolina Fernandes Tozzi, Saulo Gribel, Bruno Frazao Gribel, Giovana Cherubini Venezian, Caroline do Carmo Menezes, William Custodio
Summary: The study aimed to quantify mandibular ramus height and condylar distances asymmetry indexes in adult patients with different vertical facial growth patterns using Cone Beam computed tomography (CBCT). The results showed significantly lower mandibular ramus height in individuals with a hyperdivergent skeletal pattern, but no statistically significant differences in condylar and intercondylar distances among different facial groups. Asymmetry indexes for mandibular ramus height and condylar distance were similar regardless of the skeletal patterns.
SURGICAL AND RADIOLOGIC ANATOMY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Claudia Viviane Guimaraes Pellissari, Janaina Habib Jorge, Lina Maria Marin, Robinson Sabino-Silva, Walter Luiz Siqueira
Summary: The study evaluated the effect of statherin and its naturally occurring peptides on Candida albicans metabolism and biofilm development. The peptides were found to decrease the viability and proliferation of Candida albicans, with IT-32 showing the most significant reduction in cell proliferation and biomass. These results suggest that statherin peptides have potential in reducing Candida albicans colonization and biofilm proliferation.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yi Zhu, Lina M. Marin, Yizhi Xiao, Elizabeth R. Gillies, Walter L. Siqueira
Summary: Salivary proteins like histatins play important roles in tooth health. Chitosan nanoparticles show promise in protecting these proteins from enzymatic degradation in the oral environment, especially in acidic conditions. The results demonstrate their potential as carriers for oral applications.
Article
Dentistry, Oral Surgery & Medicine
Igor Salmoria, Evaldo Chaves de Souza, Alvaro Furtado, Cristina Maria Franzini, William Custodio
Summary: The MARPE therapy significantly corrected the transverse defect of the maxillary basal bone in adult patients, regardless of the ossification degree of the midpalatal suture. Patients in stage D had wider interincisal diastema and suture opening compared to stage E patients.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sigmar Miguel Schmidt, Giovana Cherubini Venezian, William Custodio, Carolina Carmo de Menezes, Silvia Amelia Scudeller Vedovello, Viviane Veroni Degan
Summary: The study found that within the university context, women and undergraduate students enrolled in night courses were more likely to present with symptoms related to temporomandibular disorder (TMD).
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2021)
Article
Biochemical Research Methods
Lina M. Marin, Jaime A. Cury, Walter L. Siqueira
Summary: In this study, an in vitro cariogenic Streptococcus mutans biofilm model was modified and validated by assessing the dose-response effect of fluoride on enamel demineralization. The model demonstrated a dose-response effect of fluoride in influencing enamel demineralization, showing the potential for assessing novel biotechnological strategies for caries prevention.
JOURNAL OF MICROBIOLOGICAL METHODS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sreenath Madathil, Walter L. Siqueira, Lina M. Marin, Farisa Banu Sanaulla, Nancy Faraj, Carlos R. Quinonez, Mary McNally, Michael Glogauer, Paul Allison
Summary: This study estimated the COVID-19 incidence rates among Canadian dentists and found a low infection rate, which should be reassuring to both dentists and the general community. It emphasizes the importance of continued disease surveillance data collection.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Review
Medicine, General & Internal
Pedro Urquiza Jayme Silva, Millena Barroso Oliveira, Walbert Vieira, Sergio Vitorino Cardoso, Cauane Blumenberg, Ademir Franco, Walter Luiz Siqueira, Luiz Renato Paranhos
Summary: The outcomes of this study suggest that the occurrence of oral pigmentation induced by chloroquine or hydroxychloroquine is associated with the dosage and treatment length, with a higher risk observed in long-term treatment with higher dosages.
Article
Microbiology
Lina Maria Marin, Yizhi Xiao, Jaime Aparecido Cury, Walter Luiz Siqueira
Summary: The engineered salivary peptide DR9-RR14 has been shown to effectively reduce enamel demineralization, but has no significant impact on biofilm biomass or the expression of cariogenic bacterial proteins. This suggests that DR9-RR14 may primarily control caries development through a physicochemical mechanism.
Article
Dentistry, Oral Surgery & Medicine
Crislaine A. L. Machado, Diego Patrik A. Carneiro, Patricia R. Dos Santos, Mario Vedovello Filho, William Custodio, Marcelo de C. Meneghim, Silvia A. S. Vedovello
Summary: This study aimed to investigate the impact of tooth wear on masticatory quality and eating habits in a Brazilian indigenous population. The results showed that 38.1% of the indigenous population had tooth wear, and 48.2% reported that their masticatory function was affected. There was a significant association between adulthood and tooth wear in this sample.
INTERNATIONAL ORTHODONTICS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Paras Ahmad, Ahmed Hussain, Alonso Carrasco-Labra, Walter L. Siqueira
Summary: Salivary proteins play an important role in the repair of damaged tissues and the maintenance of oral health. This systematic review aimed to assess the association between caries and salivary proteins by comparing caries-free (CF) and caries-active (CA) individuals. The results showed that the levels of certain salivary proteins were significantly increased in CA patients, while others were significantly increased in CF subjects. However, there were conflicting results regarding the salivary levels of immunoglobulin-A and total proteins among CA and CF subjects. Due to significant heterogeneity among the included studies, no meta-analysis could be performed. Therefore, larger prospective studies are needed to verify the diagnostic value of salivary proteins as biomarkers for caries.
Article
Dentistry, Oral Surgery & Medicine
Fabio Ferreira Aneris, Ossam El Haje, Henrique Damian Rosario, Carolina Carmo de Menezes, Cristina Maria Franzini, William Custodio
Summary: This study compared the volumetric changes of the upper airway after MARPE therapy in adult patients with maxillary deficiencies. The results showed that MARPE therapy can increase the size of the upper airway in adult patients, regardless of the degree of midpalatal suture ossification.
JOURNAL OF THE WORLD FEDERATION OF ORTHODONTISTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Julian Calegari Ayala, Celia Marisa Rizzatti-Barbosa, William Custodio
Summary: This study aimed to investigate the effects of botulinum toxin A (BoNTA) injection on pain perception (PP) and condyle-fossa relationship (CFR) in patients with painful muscular temporomandibular dysfunction (TMD). The results showed that BoNTA injection did not significantly affect PP and CFR in TMD patients, except for the frontal lateral space of CFR.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2023)
Article
Multidisciplinary Sciences
Dina G. Moussa, Walter L. Siqueira
Summary: Dental caries is a widespread chronic disease globally, and research on enamel pellicle (AEP) suggests its crucial role in protecting teeth by controlling bacterial adhesion and plaque formation. Novel hybrid constructs and the integration of functional domains of salivary proteins/peptides have shown promising multifunctional preventive effects against caries.
SCIENTIFIC REPORTS
(2021)
