Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine

First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo

(2013) Kaidi Zhou et al.   BIOCHEMICAL PHARMACOLOGY

Influence of Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) Polymorphisms on Pain Sensitivity and Clinical Response to Weak Opioid Analgesics

(2013) Zalina Zahari et al.   Drug Metabolism and Pharmacokinetics

The endogenous substrates of brain CYP2D

(2013) Xiaoshuang Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

LC–MS/MS method for the quantification of almotriptan in dialysates: Application to rat brain and blood microdialysis study

(2013) Ramakrishna Nirogi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cytochrome P450–mediated drug metabolism in the brain

(2013) Sharon Miksys et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Study of the pharmacokinetic changes of Tramadol in diabetic rats

(2013) Hoda Lavasani et al.   DARU-Journal of Pharmaceutical Sciences

Development and Validation of a New GC-MS Method for the Detection of Tramadol, O-Desmethyltramadol, 6-Acetylmorphine and Morphine in Blood, Brain, Liver and Kidney of Wistar Rats Treated with the Combination of Heroin and Tramadol

(2012) T. Mahdy et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Quantitative analysis of olanzapine in rat brain microdialysates by HPLC–MS/MS coupled with column-switching technique

(2012) Qiaoling Zheng et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration

(2011) LeeCole Legette et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cytochrome P450 enzymes in the brain: emerging evidence of biological significance

(2011) Charmaine S. Ferguson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of metamizol on morphine pharmacokinetics and pharmacodynamics after acute and subchronic administration in arthritic rats

(2010) Adriana Miriam Domínguez-Ramírez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders

(2010) Fabien Dutheil et al.   Expert Opinion on Drug Metabolism & Toxicology

Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function

(2009) F. Dutheil et al.   DRUG METABOLISM AND DISPOSITION

Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment

(2008) Amandeep Mann et al.   NEUROPHARMACOLOGY

Brain Drug-Metabolizing Cytochrome P450 Enzymes are Active In Vivo, Demonstrated by Mechanism-Based Enzyme Inhibition

(2008) Sharon Miksys et al.   NEUROPSYCHOPHARMACOLOGY