Extensive intestinal glucuronidation of raloxifenein vivoin pigs and impact for oral drug delivery

BDDCS Applied to Over 900 Drugs

(2011) Leslie Z. Benet et al.   AAPS Journal

In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5 -Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

(2011) A. Lundahl et al.   DRUG METABOLISM AND DISPOSITION

Impact of Intestinal Glucuronidation on the Pharmacokinetics of Raloxifene

(2011) K. Kosaka et al.   DRUG METABOLISM AND DISPOSITION

Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry

(2011) B. Achour et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

(2011) H. E. Cubitt et al.   DRUG METABOLISM AND DISPOSITION

Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans

(2011) Helena Anna Thörn et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Determination of raloxifene and its glucuronides in human urine by liquid chromatography–tandem mass spectrometry assay

(2011) Tina Trdan et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Different Effects of Ketoconazole on the Stereoselective First-Pass Metabolism of R/S-Verapamil in the Intestine and the Liver: Important for the Mechanistic Understanding of First-Pass Drug-Drug Interactions

(2009) H. A. Thorn et al.   DRUG METABOLISM AND DISPOSITION

Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: A study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10

(2009) Takashi Mizuma   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Relative Importance of Intestinal and Hepatic Glucuronidation—Impact on the Prediction of Drug Clearance

(2009) Helen E. Cubitt et al.   PHARMACEUTICAL RESEARCH

Effect of Intestinal Glucuronidation in Limiting Hepatic Exposure and Bioactivation of Raloxifene in Humans and Rats

(2008) Deepak Dalvie et al.   CHEMICAL RESEARCH IN TOXICOLOGY