Article
Gastroenterology & Hepatology
Jiazeng Sun, Guanhui Wu, Florentin Pastor, Naimur Rahman, Wen-Hung Wang, Zhengtao Zhang, Philippe Merle, Lijian Hui, Anna Salvetti, David Durantel, Danzhou Yang, Ourania Andrisani
Summary: The study demonstrates that RNA helicase DDX5 plays a crucial role in regulating STAT1 translation by resolving a G-quadruplex structure in the 5' UTR of STAT1 mRNA, and is essential for IFN response. The absence of DDX5 correlates with reduced STAT1 expression and weakened anti-viral effect of IFN-alpha in HBV-infected cells, highlighting the importance of DDX5 in controlling the dynamic range of IFN response.
Article
Materials Science, Multidisciplinary
Xu Sun, Junliang Chang, Qing Dong, Hao Wang, Xuemei Zhang, Dan Li, Haicheng Gao, Erkang Wang, Jin Wang
Summary: Polyethyleneimine (PEI)-modified magnetic nanoparticles (Fe3O4@PEI MNPs) were synthesized and used as a substitute for enzymes in the detection of interferon alpha-2b (IFN-a2b). This method offers a higher sensitivity, lower cost and increased stability compared to traditional enzyme-based assays.
SCIENCE CHINA-MATERIALS
(2023)
Article
Infectious Diseases
Ying-Zi Ye, Ya-Lan Dou, Jian-Hua Hao, Li Zhou, Ai-Wei Lin, Shao-Ning Wang, Ji-Kui Deng, Min Lei, Ru-Ping Luo, Yi-Nan Liao, Yan Chen, Yuan-Yuan Long, Bi-Quan Chen, Zhi Yang, Lu Gan, Guang-Min Nong, Wei-Li Yan, Hui Yu
Summary: The study found that interferon alpha-2b spray showed better efficacy in treating acute herpangina in children compared to Ribavirin. Additionally, it was deemed safe for use with no adverse reactions reported.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Chemistry, Analytical
Boris Nikolaev, Ludmila Yakovleva, Viacheslav Fedorov, Natalia Yudintceva, Vyacheslav Ryzhov, Yaroslav Marchenko, Alexander Ischenko, Alexander Zhakhov, Anatoliy Dobrodumov, Stephanie E. Combs, Huile Gao, Maxim Shevtsov
Summary: Type I interferons, particularly IFNa-2b, play crucial roles in immune responses and are associated with the development of various diseases. Therefore, it is essential to develop a highly sensitive platform for the analysis of IFNa-2b and anti-IFNa-2b antibodies to improve diagnosis.
Article
Oncology
Dong-Dong Jia, Yanling Niu, Honglin Zhu, Sizhen Wang, Tonghui Ma, Tao Li
Summary: This study investigated the impact of prior IFN-alpha therapy on subsequent PD-1 blockade in melanoma patients. The findings showed that prior PEG-IFN-alpha therapy enhanced the efficacy of adjuvant pembrolizumab, reducing recurrence rates and prolonging recurrence-free survival. These results suggest that prior PEG-IFN-alpha treatment could be beneficial in designing combination or sequential immunotherapy for melanoma patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Fei Xiong, Qi Wang, Guan-hua Wu, Wen-zheng Liu, Bing Wang, Yong-jun Chen
Summary: IFN-alpha 2b is a highly active cytokine that has antiviral, antitumour, antiparasitic, and immunomodulatory activities. Its antiproliferative effects are mainly mediated through the JAK-STAT pathway. Regulators of IFN-alpha 2b function may help improve its therapeutic efficacy.
BIOMARKER RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Yan Sun, Jianqun Xu, Hongya Zhou, Lina You, Yan Zhu
Summary: The combination therapy of lacidophilin vaginal capsules plus recombinant human interferon alpha-2b shows better clinical effects for HPV-infected patients compared to using rh-IFN-alpha 2b alone. It can significantly improve negative conversion ratio, overall response rate, vaginal microecology, and restoration rate without increasing adverse events.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Ophthalmology
Wathanee Sripawadkul, Daniela Reyes-Capo, Mike Zein, Adam Wylegala, Ghada Albayyat, Anat Galor, Carol L. Karp
Summary: This retrospective study assessed the efficacy of topical interferon alpha-2 beta eye drops in the treatment of ocular surface squamous neoplasia (OSSN). The results showed that 80.4% of patients achieved complete tumor resolution, with a low recurrence rate of 0%, 2.3%, and 3.1% at 1, 2, and 5 years respectively. Mild hyperemia and pain were the most common side effects. Therefore, topical interferon alpha-2 beta eye drops can be considered as a safe and effective primary treatment for OSSN.
Article
Oncology
Yingxin Sun, Yifeng Cai, Jiannong Cen, Mingqing Zhu, Jinlan Pan, Qian Wang, Depei Wu, Suning Chen
Summary: Peg-IFN demonstrates promising hematologic and molecular responses in patients with PV and ET, and is safe, effective, and well tolerated in most patients. However, a small percentage of patients had to discontinue treatment due to drug-related toxicity. Further exploration of Peg-IFN alone or in combination with other drugs is needed to minimize treatment-related toxicity and improve tolerability.
FRONTIERS IN ONCOLOGY
(2021)
Review
Ophthalmology
Pau Cid-Bertomeu, Valentin Huerva
Summary: Primary acquired melanosis (PAM) is a conjunctival pigmentation that can lead to conjunctival melanoma (CM). Surgical excision is the preferred treatment, but topical chemotherapy with interferon alpha 2b (IFN-a2b) is also an important option. IFN-a2b has shown efficacy in treating PAM and CM, with low toxicity.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Oncology
Kazuki Sakatoku, Yasuhiro Nakashima, Joji Nagasaki, Mitsutaka Nishimoto, Asao Hirose, Mika Nakamae, Hideo Koh, Masayuki Hino, Hirohisa Nakamae
Summary: This study evaluated the direct cytotoxic effects and indirect effects induced by ropeginterferon alfa-2b in tumor cells using a leukemia model developed in immunocompetent mice. The results showed that the host adoptive immunostimulatory effect of ropeginterferon alfa-2b is the dominant mechanism through which tumor cells are suppressed. Furthermore, T cells function independently in immunological memory.
Article
Oncology
Shijie Lan, Zhihua Cui, Qiliang Yin, Zhigang Liu, Lingling Liang, Hua He, Hesong Liu, Zhen Guo, Yingying Yu, Di Wu
Summary: This study investigated the clinical characteristics of Chinese melanoma patients who developed retinopathy following high-dose interferon alpha-2b therapy. The majority of patients developed retinopathy shortly after treatment, with common manifestations including cotton-wool spots and retinal hemorrhage. No significant differences were found in clinical characteristics and laboratory examinations between patients with and without HD-IFN-induced retinopathy.
Article
Chemistry, Physical
Konstantin A. Prosolov, Ekaterina G. Komarova, Ekaterina A. Kazantseva, Aleksandr S. Lozhkomoev, Sergei O. Kazantsev, Olga Bakina, Marina Mishina, Anastasia P. Zima, Sergei Krivoshchekov, Igor A. Khlusov, Yurii P. Sharkeev
Summary: Drug delivery systems based on calcium phosphate coatings have been recognized as potential treatments for bone diseases. This study introduces a new method, hybrid ultrasound-assisted micro-arc oxidation, for depositing calcium phosphate coatings for drug delivery. The resulting coatings exhibit suitable internal and surface porosity for drug delivery and demonstrate good cytotoxicity and antimicrobial activity.
Article
Dermatology
Jingjing Li, Jiuhong Wang, Dandan Li, Xizhi Wen, Ya Ding, Xing Liu, Hang Jiang, Fuxue Huang, Xiaoshi Zhang
Summary: This retrospective study found that adjuvant PD-1 inhibitors provided significantly longer RFS and DMFS in Chinese patients with stage IIIB/C cutaneous melanoma compared to high-dose interferon alpha-2b (HDI), but there was no significant advantage observed in patients with acral melanoma.
DERMATOLOGIC THERAPY
(2021)
Editorial Material
Hematology
Isabelle Plo, William Vainchenker
Summary: In this study, it was reported that interferon lambda 4 (IFNL4) plays a significant role as a genetic determinant of interferon-alpha (IFN-alpha)-induced molecular response (MR) in myeloproliferative neoplasms (MPNs), leading to better patient stratification.