Predicting essential genes and synthetic lethality via influence propagation in signaling pathways of cancer cell fates

Essential Plasticity and Redundancy of Metabolism Unveiled by Synthetic Lethality Analysis

(2014) Oriol Güell et al.   PLoS Computational Biology

CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy

(2013) S. McNeely et al.   PHARMACOLOGY & THERAPEUTICS

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

(2012) L. A. Carvajal et al.   GENES & DEVELOPMENT

Mining high-throughput screens for cancer drug targets-lessons from yeast chemical-genomic profiling and synthetic lethality

(2012) Marja A. Heiskanen et al.   Wiley Interdisciplinary Reviews-Data Mining and Knowledge Discovery

The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism

(2011) Fernando J Reyes-Zurita et al.   BMC CANCER

OGEE: an online gene essentiality database

(2011) Wei-Hua Chen et al.   NUCLEIC ACIDS RESEARCH

Synthetic lethality: a framework for the development of wiser cancer therapeutics

(2009) William G Kaelin   Genome Medicine

Modeling synthetic lethality

(2008) Nolwenn Le Meur et al.   GENOME BIOLOGY