Review
Pharmacology & Pharmacy
Young Hee Choi, Young-Won Chin
Summary: Studies have shown that metabolic enzyme and/or transporter-mediated pharmacokinetic changes in a drug caused by concomitant herbal products may affect efficacy and toxicity, but discrepancies between predictive data and clinical significance still exist, adding to confusion regarding the use of herbal products and drug combinations.
Review
Chemistry, Medicinal
Jie Li, Shuting Wang, Fengjie Tian, Shuang-Qing Zhang, Hongtao Jin
Summary: As the use of herbs increases worldwide, there are more reports of interactions between herbs and drugs. The complex active components of herbs inevitably affect the pharmacokinetics of chemical drugs in vivo. The expression of drug transporters is closely related to the absorption, distribution, metabolism, and excretion of drugs. When herbs inhibit or induce the expression of transporters, it can result in changes in substrate pharmacokinetics, affecting the efficacy and toxicity of drugs. This article summarizes the tissue distribution and physiological functions of drug transporters, analyzes the effects of herbs on drug transporters, and discusses the possible mechanisms of herb-drug interactions, providing ideas and references for safe clinical drug use.
Article
Pharmacology & Pharmacy
Feng Zhang, Tiantian Zhang, Jiahao Gong, Qinqin Fang, Shenglan Qi, Mengting Li, Yan Han, Wei Liu, Guangbo Ge
Summary: This study demonstrates that the Chinese herb Styrax can efficiently inhibit hCYP3A4 enzyme and modulate the pharmacokinetic behavior of CYP3A-substrate drugs. It provides valuable insights for clinical pharmacologists to assess the potential herb-drug interactions triggered by Styrax or Styrax-related herbal products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Industrial
Yong He, Xuan Zhao, Harish Krishnan, Shibo Jin
Summary: This study examines how suppliers can sustain cooperation in a supply chain through repeated interactions. Collaboration can be achieved through strategies such as reversion, finite-punishment-period, and repentance. The results show that long-lasting business relationships can be maintained as an equilibrium as long as deviations are punished or the deviating partner makes amends.
INTERNATIONAL JOURNAL OF PRODUCTION ECONOMICS
(2022)
Review
Plant Sciences
Chun Sing Lam, Ho Kee Koon, Chung Tin Ma, Kwok Yin Au, Zhong Zuo, Vincent Chi-Ho Chung, Yin Ting Cheung
Summary: This scoping review summarizes pharmacoepidemiological studies that evaluate herb-drug interactions (HDI) using real-world data and identifies gaps that need to be addressed in future research.
Review
Neurosciences
Tram T. Le, Sarah R. McGrath, Pius S. Fasinu
Summary: The use of herbal products as complementary medicine alongside prescription neuropsychiatric drugs is common, but it can lead to herb-drug interactions that may jeopardize the success of pharmacotherapy. This study identified 13 commonly used herbal products that have clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders, emphasizing the importance of caution in herb-drug co-medication.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Maria D. Auxtero, Susana Chalante, Mario R. Abade, Rui Jorge, Ana Fernandes
Summary: Late-life mild cognitive impairment and dementia pose a significant burden on healthcare systems with limited treatment options. Plant phytochemicals are being considered for alternative or complementary strategies, but caution is needed due to potential adverse effects and pharmacological interactions. Understanding and preventing these risks is crucial, especially for aged, polymedicated individuals.
Article
Oncology
H. Prely, C. Herledan, A. G. Caffin, A. Baudouin, V Larbre, M. Maire, V Schwiertz, N. Vantard, F. Ranchon, C. Rioufol
Summary: This study found that potentially clinically relevant drug interactions were frequently identified in outpatients taking oral anticancer drugs, highlighting the need for multiple databases and structured screening to detect more interactions and optimize medication safety.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Heng Li, Ying-Jie Wang, Xiao-Nan Geng, Yao-Ren Kang, Yi-Lin Wang, Xiang-Jun Qiu
Summary: A sensitive and rapid UPLC-MS/MS method for determining the concentration of tazemetostat in rat plasma was developed. The pharmacokinetics of herb-drug interactions between plumbagin and tazemetostat were investigated.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Chemistry, Medicinal
Archana K. Thikekar, Asha B. Thomas, Sohan S. Chitlange
Summary: The global diabetes epidemic is a major cause of fatality and lethality, with the use of medicinal plants becoming increasingly popular for disease treatment. However, more high-quality research is needed to evaluate the efficacy of herbal medicines, reduce side effects, and improve patient safety.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Zhenchao Niu, Tingting Qiang, Wenyong Lin, Yiping Li, Keyan Wang, Dan Wang, Xiaolong Wang
Summary: This study explored the potential herb-drug interactions between Shengmai injection (SMI) and losartan potassium (LOS) and found that SMI can enhance the antihypertensive efficacy of LOS by influencing its pharmacokinetic properties. The effects of SMI on LOS may be attributed to the inhibition of CYP3A4, CYP2C9, and drug transporters.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Dai-yan Zhang, Wen-qing Cui, Ling Hou, Jing Yang, Li-yang Lyu, Ze-yu Wang, Ke-Gang Linghu, Wen-bin He, Hua Yu, Yuan-jia Hu
Summary: This study aims to expand potential targets and verify drug-herb interactions using the node2vec algorithm. The results show that node2vec algorithm performs the best among all algorithms and successfully identifies potential interactions between 32 herbal chemicals and drug targets.
Review
Chemistry, Medicinal
Apisada Jiso, Phisit Khemawoot, Pinnakarn Techapichetvanich, Sutinee Soopairin, Kittiphong Phoemsap, Panrawee Damrongsakul, Supakit Wongwiwatthananukit, Pornpun Vivithanaporn
Summary: More than half of Thai cancer patients take herbal preparations while undergoing anticancer therapy. There is a lack of systematic research on interactions between anticancer drugs and Thai herbs, although some studies suggest that Thai herbs may inhibit the metabolism and transport of anticancer drugs.
Article
Plant Sciences
Mustapha Chelghoum, Walid Khitri, Samia Bouzid, AbdelRahim Lakermi
Summary: The study found a decrease in the use of medicinal plants by diabetic patients in Algeria, with some herbs not cited by traditional healers. Patients on oral anti-diabetic agents were twice as likely to use plants concurrently with drugs. Olive leaves and fenugreek seeds were the most cited herbal plants.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sanowar Hossain, Muhammad Yousaf, Yang Liu, Dennis Chang, Xian Zhou
Summary: This article reviews the drug-herb interactions between full-spectrum propolis extract and main pharmaceutical drugs and elucidates the pharmacological mechanisms. From a pharmacodynamic perspective, propolis extract has positive or synergistic interaction with chemotherapeutic drugs, antimicrobial drugs, antidiabetic drugs, and neurological drugs. From a pharmacokinetic perspective, propolis extracts have inhibitory activities on CYP450 enzymes, but the effects are insignificant in humans.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
K. Abass, A. Huusko, H. K. Knutsen, P. Nieminen, P. Myllynen, H. M. Meltzer, K. Vahakangas, A. Rautio
ENVIRONMENT INTERNATIONAL
(2018)
Review
Environmental Sciences
Pernilla Carlsson, Knut Breivik, Eva Brorstrom-Lunden, Ian Cousins, Jesper Christensen, Joan O. Grimalt, Crispin Halsall, Roland Kallenborn, Khaled Abass, Gerhard Lammel, John Munthe, Matthew MacLeod, Jon Oyvind Odland, Janet Pawlak, Arja Rautio, Lars-Otto Reiersen, Martin Schlabach, Irene Stemmler, Simon Wilson, Henry Wohrnschimmel
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Public, Environmental & Occupational Health
B. Adlard, S. G. Donaldson, J. O. Odland, P. Weihe, J. Berner, A. Carlsen, E. C. Bonefeld-Jorgensen, A. A. Dudarev, J. C. Gibson, E. M. Krummel, K. Olafsdottir, K. Abass, A. Rautio, I. A. Bergdahl, G. Mulvad
GLOBAL HEALTH ACTION
(2018)
Review
Environmental Sciences
Khaled Abass, Anastasia Emelyanova, Arja Rautio
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Review
Environmental Sciences
Audrey Waits, Anastasia Emelyanova, Antti Oksanen, Khaled Abass, Arja Rautio
ENVIRONMENT INTERNATIONAL
(2018)
Article
Biochemistry & Molecular Biology
Saranya Palaniswamy, Terhi Piltonen, Markku Koiranen, Darja Mazej, Marjo-Riitta Jarvelin, Khaled Abassh, Arja Rautio, Sylvain Sebert
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2019)
Correction
Environmental Sciences
Khaled Abass, Anastasia Emelyanova, Arja Rautio
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Jenni Kublbeck, Taina Vuorio, Jonna Niskanen, Vittorio Fortino, Albert Braeuning, Khaled Abass, Arja Rautio, Jukka Hakkola, Paavo Honkakoski, Anna-Liisa Levonen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Green & Sustainable Science & Technology
Joan Nymand Larsen, Peter Schweitzer, Khaled Abass, Natalia Doloisio, Susanna Gartler, Thomas Ingeman-Nielsen, Jon Haukur Ingimundarson, Leneisja Jungsberg, Alexandra Meyer, Arja Rautio, Johanna Scheer, Ulla Timlin, Jean-Paul Vanderlinden, Magali Vullierme
Summary: Thawing permafrost poses significant risks to Arctic coastal communities, emphasizing the importance of dual dimensions of risk and risk perception. Collaboration across disciplines and co-production of risk management with local communities is crucial for identifying and addressing risks effectively.
Review
Biochemistry & Molecular Biology
Khaled Abass, Olavi Pelkonen, Arja Rautio
Summary: Chloro-s-triazines such as atrazine, cyanazine, propazine, simazine, and terbuthylazine are structurally similar herbicides with similar toxicokinetics. By comparing their characteristics, useful structure-activity relationships can be identified to enhance toxicological risk assessment for humans and ecosystems.
CURRENT DRUG METABOLISM
(2021)
Article
Environmental Sciences
Saranya Palaniswamy, Khaled Abass, Jaana Rysa, Jon oyvind Odland, Joan O. Grimalt, Arja Rautio, Marjo-Riitta Jarvelin
Summary: In a Finnish cohort study, non-occupational overall pesticide exposure, length of exposure and specific pesticides were found to be associated with multiple biological markers of health, indicating adverse effects of pesticides and the need for further research to replicate findings and determine underlying mechanisms.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Kam Sripada, Aneta Wierzbicka, Khaled Abass, Joan O. Grimalt, Andreas Erbe, Halina B. Rollin, Pal Weihe, Gabriela Jimenez Diaz, Randolph Reyes Singh, Torkild Visnes, Arja Rautio, Jon Oyvind Odland, Martin Wagner
Summary: This commentary summarizes the knowns and unknowns about exposures to nano-and microplastics (NMPs) during pregnancy and childhood. Currently, there is a lack of research on child-specific exposures to NMPs, and exposure estimates rely on assumptions rather than empirical measurements. Furthermore, the toxicological research on NMPs has not focused specifically on child health, despite their vulnerability. More research is needed to fill these knowledge gaps and spur policymakers and industries to address the safety of NMPs.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Shanshan Xu, Solrunn Hansen, Arja Rautio, Marjo-Riitta Jarvelin, Khaled Abass, Jaana Rysa, Saranya Palaniswamy, Sandra Huber, Joan O. Grimalt, Pierre Dumas, Jon Oyvind Odland
Summary: This study found lower levels of selected persistent organic pollutants (POPs) in the serum of women from Northern Norway, with concentrations of dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and chlorinated paraffins showing decreasing trends over the studied period. However, medium chain chlorinated paraffins exhibited an increasing trend, raising concerns about their emerging contamination impact on humans. Further global observational studies with larger sample sizes on chlorinated paraffins are needed to validate these findings.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Khaled Abass, Tatiana Unguryanu, Eva Junque, Darja Mazej, Janja Snoj Tratnik, Milena Horvat, Joan O. Grimalt, Paivi Myllynen, Arja Rautio
Summary: In the Finnish Lapland, possible pollution transferred from the Pechenganikel industrial complex was investigated. Food samples and blood samples of pregnant women from the local area were analyzed, and detectable levels of organochlorine compounds and metal(oids) were found. However, the levels of these pollutants did not exceed safe limits, and there was a decrease in pollutant concentrations compared to previous studies.
ENVIRONMENTAL RESEARCH
(2022)
Article
Toxicology
Karine Audouze, Elias Zgheib, Khaled Abass, Asma H. Baig, Isabel Forner-Piquer, Henrik Holbech, Dries Knapen, Pim E. G. Leonards, Diana I. Lupu, Saranya Palaniswamy, Arja Rautio, Maria Sapounidou, Olwenn V. Martin
FRONTIERS IN TOXICOLOGY
(2021)