Article
Biochemistry & Molecular Biology
Rozalia-Maria Anastasiadi, Federico Berti, Silvia Colomban, Claudio Tavagnacco, Luciano Navarini, Marina Resmini
Summary: A simple, cheap, and fast electrochemical method was developed to simultaneously quantify paraxanthine and caffeine in human saliva, using differential pulse voltammetry. The method was successfully demonstrated in a small-scale trial on healthy volunteers, with results validated by ultra-high pressure liquid chromatography.
Article
Pharmacology & Pharmacy
Rongjie Zhang, Yuanfeiyi Wang, Dan Liu, Qing Luo, Peixin Du, Haiyan Zhang, Wenshuang Wu
Summary: Sodium tanshinone IIA sulfonate (STS) acts as an immunotherapy agent by inhibiting both IDO1 and TDO2 in colorectal cancer (CRC).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Peipei Chen, Qiyuan An, Yuxin Huang, Minzhou Zhang, Shuai Mao
Summary: This study demonstrates that STS can increase survival rates in mice, improve compromised cardiac function, reduce myocardial inflammatory injury, and promote autophagy while attenuating NLRP3 inflammasome activation. Additionally, STS may alleviate endotoxemia-induced mortality and cardiomyopathy by promoting autophagy and inhibiting NLRP3 inflammasome overactivation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Maolin Sun, Chaoming Liang, Liming Cao, Yaguo Wang, Jiasheng Yang, Shiyu Hou, Wei Yu, Yueyue Ma, Ruihua Cheng, Jinxing Ye
Summary: A sustainable and practical approach is presented for the direct synthesis of sodium tanshinone IIA sulfonate (STS). A two-step continuous flow platform was constructed, which achieved a higher yield and improved procedural safety compared to the batch synthetic route. The proposed method also reduced the required acid content and wastewater production.
CHINESE CHEMICAL LETTERS
(2024)
Article
Medicine, Research & Experimental
Jiazhen Xu, Pei Zhang, Yao Chen, Yulan Xu, Pengwei Luan, Yuying Zhu, Jiange Zhang
Summary: In a rat model of ischemic stroke, STS showed therapeutic effects similar to edaravone in promoting angiogenesis and inhibiting neuronal apoptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jiao Lan, Ke Li, Austin Gresham, Jifei Miao
Summary: The study found that TSS exerts anti-inflammatory effects by upregulating circ-Sirt1 expression to inhibit the translocation of NF-kappa B. In vivo experiments confirmed the protective function of TSS on inflammation, suggesting that TSS may be a potential treatment for inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Plant Sciences
Huikai Shao, Chuanyan Fang, Yang Huang, Yulong Ye, Rongsheng Tong
Summary: The meta-analysis revealed that STS injection as adjunctive therapy is more effective in treating heart failure compared to western medicine alone, showing improvements in overall effective rate, cardiac function parameters, and reductions in ventricular dimensions and BNP levels.
Article
Cardiac & Cardiovascular Systems
Yan-Yan Heng, Hui-Juan Shang, Xia-ze Zhang, Wei Wei
Summary: The study demonstrated that STS protects EPCs by inhibiting the NLRP3 pathway, preserving their proliferation and differentiation functions, and preventing senescence. STS also restores the expression of key proteins in EPCs and prevents neointima formation in diabetic mice.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Endocrinology & Metabolism
Hui-Han Ma, Can Wan, Lu-Di Zhang, Rong-Rong Zhang, Dong Peng, Li-Jun Qiao, Shi-Jie Zhang, Ye-Feng Cai, Hong-Qiang Huang
Summary: This study found that STS can improve learning and memory abilities in APP/PS1 mice and ameliorate AD pathology through multiple pathways, including reducing oxidative stress levels, enhancing antioxidant enzyme activity, inhibiting acetylcholinesterase activity, and increasing the expression of synaptic-related proteins.
METABOLIC BRAIN DISEASE
(2022)
Article
Spectroscopy
Martynas Velicka, Edvinas Zacharovas, Sonata Adomaviciute, Valdas Sablinskas
Summary: This study applied EC-SERS spectroscopy to detect caffeine intake from human saliva, showing that low-dose caffeine consumption can be detected by the appearance of characteristic SERS bands of caffeine and paraxanthine at 692 cm(-1). The method proved to be viable for clinical applications with a detection limit of paraxanthine in saliva as low as 15 mu M, which can be further improved.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Pharmacology & Pharmacy
Baoli Zhang, Peng Yu, Enyong Su, Jianguo Jia, Chunyu Zhang, Shiyao Xie, Zhenhui Huang, Ying Dong, Jinguo Ding, Yunzeng Zou, Hong Jiang, Junbo Ge
Summary: Sodium tanshinone IIA sulfonate (STS) can improve pathological cardiac remodeling after myocardial infarction (MI) through reducing myocardial necrosis, modulating inflammation, and increasing angiogenesis.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pharmacology & Pharmacy
Jian Wang, Wenyan Liu, Wenju Lu, Xiaoyun Luo, Yongrui Lin, Shiyun Liu, Jing Qian, Chenting Zhang, Haixia Chen, Yi Li, Xiang Li, Jiyuan Chen, Yuqin Chen, Qian Jiang, Chunli Liu, Cheng Hong, Tao Wang, Haiyang Tang, Nanshan Zhong, Jun Yang, Kai Yang, Dejun Sun
Summary: This study demonstrates that STS exerts anti-apoptotic effects in pulmonary endothelium and PMVECs by inducing the BMP9-BMPR2-Smad1/5/9 signaling transduction.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Ji Zhu, Hang Chen, Jianan Guo, Chen Zha, Dezhao Lu
Summary: This study investigated the protective role of sodium tanshinone IIA sulfonate (STS) in atherosclerosis (AS). The results showed that STS can regulate endothelial cell mitochondrial function and pyroptosis through an AMPK-dependent mitochondrial pathway. The study found that STS treatment enhanced maintenance of mitochondrial homeostasis and inhibited mitochondrial ROS overproduction via AMPK, thereby improving endothelial cell pyroptosis during AS. These findings suggest that STS has potential therapeutic effects in AS through its antioxidant and anti-inflammatory properties.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Zheyi Wang, Yize Sun, Lihua Bian, Yiling Zhang, Yue Zhang, Chunguo Wang, Jinzhou Tian, Tao Lu
Summary: This study used high-throughput proteomics to identify the targets and mechanisms of Sodium tanshinone IIA sulfonate (STS) in the treatment of stroke. The results showed improved neurological function and reduced damage in the stroke model rats treated with STS. Proteomic analysis revealed core proteins and signaling pathways associated with stroke. STS may have potential therapeutic effects on ischemic cerebral infarction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhi Ma, Yue Wu, Juan Xu, Hui Cao, Mingyang Du, Haibo Jiang, Feng Qiu
Summary: This study found that STS can protect neurons from oxygen-glucose deprivation/reoxygenation (OGD/R) induced injury by regulating microglia autophagy and inflammatory activity. Forced overexpression of PP2A gene induced autophagy in microglia, which increased the production of anti-inflammatory factors and decreased the release of proinflammatory cytokines. This ultimately improved mitochondrial function and prevented neuronal apoptosis.
NEUROCHEMICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jian Xiao, Dan Chen, Xiu-Xian Lin, Shi-Fang Peng, Mei-Fang Xiao, Wei-Hua Huang, Yi-Cheng Wang, Jing-Bo Peng, Wei Zhang, Dong-Sheng Ouyang, Yao Chen
Article
Pharmacology & Pharmacy
D. Chen, X. -X. Lin, W. -H. Huang, W. Zhang, Z. -R. Tan, J. -B. Peng, Y. -C. Wang, Y. Guo, D. -L. Hu, Y. Chen
Article
Pharmacology & Pharmacy
D. Chen, X. -X. Lin, Q. Zhao, J. Xiao, S. -F. Peng, M. -F. Xiao, D. -S. Ouyang, Z. -R. Tan, Y. -C. Wang, J. -B. Peng, W. Zhang, Y. Chen
Article
Integrative & Complementary Medicine
Dong-sheng Ouyang, Wei-hua Huang, Dan Chen, Wei Zhang, Zhi-rong Tan, Jing-bo Peng, Yi-cheng Wang, Ying Guo, Dong-li Hu, Jian Xiao, Yao Chen
Article
Pharmacology & Pharmacy
Xiu-Xian Lin, Guang-Hui Lian, Ying Xu, Qing Zhao, Jian Xiao, Shi-Fang Peng, Mei-Fang Xiao, Dong-Sheng Ouyang, Zhi-Rong Tan, Yi-Cheng Wang, Jing-Bo Peng, Wei Zhang, Yao Chen
Review
Substance Abuse
Xiu-Xian Lin, Guang-Hui Lian, Shi-Fang Peng, Qing Zhao, Ying Xu, Dong-Sheng Ou-Yang, Wei Zhang, Yao Chen
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Yao Chen, Chang-Qiong Xiao, Yi-Jing He, Bi-Lian Chen, Guo Wang, Gan Zhou, Wei Zhang, Zhi-Rong Tan, Shan Cao, Li-Ping Wang, Hong-Hao Zhou
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2011)
Article
Pharmacology & Pharmacy
Yao Chen, Wei Zhang, Wei-hua Huang, Zhi-rong Tan, Yi-cheng Wang, Xi Huang, Hong-Hao Zhou
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2013)
Article
Multidisciplinary Sciences
Xi Huang, Ying Guo, Wei-hua Huang, Wei Zhang, Zhi-rong Tan, Jing-bo Peng, Yi-cheng Wang, Dong-li Hu, Dong-sheng Ouyang, Jian Xiao, Yang Wang, Min Luo, Yao Chen
Article
Pharmacology & Pharmacy
Y. Chen, D. -S. Ouyang, Z. Kang, G. -P. Yang, Z. -R. Tan, G. Zhou, J. Yan
Article
Biotechnology & Applied Microbiology
Jian Xiao, Wei-Hua Huang, Jing-Bo Peng, Zhi-Rong Tan, Dong-Sheng Ou-Yang, Dong-Li Hu, Wei Zhang, Yao Chen
BIOMED RESEARCH INTERNATIONAL
(2014)
Article
Toxicology
Ying Xu, Dan Chen, Xiu-Xian Lin, Qing Zhao, Jing Guo, Li-jie Chen, Wei Zhang, Jian Xiao, Guang-Hui Lian, Shi-Fang Peng, Dong Guo, Hong Yang, Obinna Obianom, Yan Shu, Yao Chen
ARCHIVES OF TOXICOLOGY
(2019)
Article
Medicine, Research & Experimental
Qing Zhao, Bo Zheng, Shiquan Meng, Ying Xu, Jing Guo, Li-jie Chen, Jian Xiao, Wei Zhang, Zhi-rong Tan, Jie Tang, Lei Chen, Yao Chen
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Nutrition & Dietetics
Songxia Zhang, Ying Xu, Mengling Ye, Wenli Ye, Jian Xiao, Honghao Zhou, Wei Zhang, Yan Shu, Yun Huang, Yao Chen
Summary: This study assessed the efficacy and safety of resveratrol in alcoholic liver disease (ALD) when soaked in alcohol. The findings showed that resveratrol in liquor worsened alcoholic liver injury and had a reduced therapeutic effect.
Proceedings Paper
Automation & Control Systems
Xie Yong Fang, Chen Yao, Yu Shou Yi, Wang Ya Lin
PROCEEDINGS OF THE 2012 24TH CHINESE CONTROL AND DECISION CONFERENCE (CCDC)
(2012)