Article
Pharmacology & Pharmacy
Chang Wang, Fei Peng, Bohua Zhong, Ying Shi, Xiaomei Wang, Xueyuan Jin, Junqi Niu
Summary: The study showed that MBT1805 has therapeutic effects on ANIT-induced cholestasis, improving abnormal biochemical indicators, gallbladder enlargement, and histopathological changes. By regulating bile acid synthesis, biotransformation, and transport, MBT1805 helps relieve cholestasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Xiaohua Wu, Bei Cheng, Xiaojuan Guo, Qinqin Wu, Shan Sun, Ping He
Summary: The biochemical mechanisms of Chlamydia pneumoniae (Cpn)-induced foam cell formation in early atherosclerosis involve upregulation of SR-A1 and ACAT1, as well as downregulation of ABCA1/G1 expression by both PPAR alpha and PPAR gamma pathways.
MICROBIAL PATHOGENESIS
(2021)
Review
Cardiac & Cardiovascular Systems
Milton Packer
Summary: Qiliqiangxin (QLQX) is a traditional Chinese medicine consisting of 11 plant ingredients that exert cardiovascular effects by regulating nutrient surplus and nutrient deprivation pathways. Experimental studies and clinical trials have shown its beneficial effects in improving cardiac injuries.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Food Science & Technology
Charlotte C. J. R. Michielsen, Roland W. J. Hangelbroek, Marjolijn C. E. Bragt, Elwin R. Verheij, Suzan Wopereis, Ronald P. Mensink, Lydia A. Afman
Summary: Fenofibrate and fish oil can effectively reduce circulating triglyceride concentrations and potentially decrease the risk of developing cardiovascular diseases. Fish oil intake also leads to an increase in various unsaturated lipid species.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Feng-Zhi Xin, Ze-Hua Zhao, Xiao-Lin Liu, Qin Pan, Zi-Xuan Wang, Lin Zeng, Qian-Ren Zhang, Lin Ye, Meng-Yu Wang, Rui-Nan Zhang, Zi-Zhen Gong, Lei-Jie Huang, Chao Sun, Feng Shen, Lu Jiang, Jian-Gao Fan
Summary: The expansion of Escherichia-Shigella in NAFLD patients was found to be associated with disease severity, independent of obesity. Escherichia fergusonii induced nonobese NAFLD in rats characterized by hepatic steatosis and hepatocyte ballooning, disrupting host lipid metabolism. Additionally, E fergusonii-derived msRNA 23487 down-regulated host hepatic peroxisome proliferator-activated receptor alpha expression, contributing to liver lipid accumulation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiaoyin Ye, Tong Zhang, Han Han
Summary: The activation of FXR receptor can reduce bile acid synthesis and alleviate cholestasis, but the unresponsiveness of some patients and side effects of UDCA or OCA treatment limit their effectiveness. Therefore, researchers have begun to investigate the role of PPARα receptor in regulating bile acid metabolism and transport, and have found its anti-inflammatory effects that can improve the physiological status of patients with cholestatic liver disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tomomi Morikawa, Tatsuki Fukami, Saki Gotoh-Saito, Masataka Nakano, Miki Nakajima
Summary: This study demonstrated the regulation of human AADAC by PPAR alpha through binding to DR1, and the significance of AADAC in lipid accumulation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xin-xin Zhu, Xia Wang, Shi-yu Jiao, Ye Liu, Li Shi, Qing Xu, Jing-jing Wang, Yun-er Chen, Qi Zhang, Yan-ting Song, Ming Wei, Bao-qi Yu, Jens Fielitz, Frank J. Gonzalez, Jie Du, Ai-juan Qu
Summary: Cardiac dysfunction is a key component in sepsis-induced multi-organ failure. The peroxisome proliferator-activated receptor (PPAR) signaling pathway, especially PPARa, is significantly decreased in septic cardiomyopathy. Cardiomyocyte-specific PPARa deficiency exacerbates mitochondrial dysfunction and fatty acid metabolism impairment, leading to cardiac dysfunction. Targeting PPARa may be a therapeutic strategy for the treatment of septic cardiomyopathy.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Hongjiao Gao, Yujue Li, Xiang Chen
Summary: There is a regulatory loop between glucocorticoid receptor alpha and peroxisome proliferator-activated receptor alpha, which affects energy and lipid metabolism and has anti-inflammatory effects.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Doudou Luo, Wenxuan Ye, Ling Chen, Xiaoqian Yuan, Yali Zhang, Caixia Chen, Xin Jin, Yu Zhou
Summary: Astrocyte inflammation activation hinders motor function recovery after cerebral ischemia, and the molecular mechanism is not clearly understood. This study investigates the role of PPARa in astrocyte inflammation activation after cerebral ischemia and explores the underlying mechanism. The results show that PPARa dysfunction promotes astrocyte inflammatory activation, while PPARa activation preserves lysosome function and restores autophagic flux in astrocytes after oxygen-glucose deprivation/reoxygenation (OGD/R).
Article
Cell Biology
Jiangping He, Cong Yu, Yunlong Shen, Jiao Huang, Yanzi Zhou, Jianmin Gu, Ying Cao, Quan Zheng
Summary: In this study, we found that SIRT6 is predominantly expressed in alveolar epithelial cells and can protect against injury and reduce fibrosis in the lungs. SIRT6 enhances lipid degradation to decrease lipid peroxide levels, and this process relies on PPARa-mediated lipid catabolism and anti-inflammatory responses. Targeting SIRT6-PPARa-mediated lipid catabolism may be a potential therapeutic strategy for diseases complicated with pulmonary fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Guoyan Wang, Jun Zhang, Shengru Wu, Senlin Qin, Yining Zheng, Chao Xia, Huijun Geng, Junhu Yao, Lu Deng
Summary: Cattle have a unique mechanism for efficient hepatic gluconeogenesis, involving the high expression of specific genes and the activation of the mTORC1 signaling pathway. These findings are important for understanding the mechanism underlying the quantitative differences in hepatic gluconeogenesis efficiency between cattle and non-ruminant animals.
Article
Chemistry, Multidisciplinary
Jie Yang, Xiao Yang, Yi-fei Zhang, Jia-ning Tian, Shi-cheng Fan, Yue Gao, Hui-lin Li, Cheng-hui Cai, Min Huang, Hui-chang Bi
Summary: In this study, it was found that activation of PPARa leads to hepatomegaly in mice, with hepatocyte hypertrophy around the central vein area and hepatocyte proliferation around the portal vein area. The study also revealed that the upregulation of PPARa targets is higher in the central vein area compared to the portal vein area, while the upregulation of proliferation-related proteins mainly occurs in the portal vein area. These findings provide new insights into the understanding of PPARa activation-induced liver enlargement and regeneration.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Yixin Lin, Kristin M. Bircsak, Ludwik Gorczyca, Xia Wen, Lauren M. Aleksunes
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2017)
Article
Medicine, Research & Experimental
Blessy George, Melanie S. Joy, Lauren M. Aleksunes
EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Cara Chang, Yichun Hu, Susan L. Hogan, Nickie Mercke, Madeleine Gomez, Cindy O'Bryant, DanielW. Bowles, Blessy George, Xia Wen, Lauren M. Aleksunes, Melanie S. Joy
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Chemistry, Multidisciplinary
Xia Wen, Melanie S. Joy, Lauren M. Aleksunes
PHARMACEUTICAL RESEARCH
(2017)
Article
Developmental Biology
Lissa N. Francois, Ludwik Gorczyca, Jianyao Du, Kristin M. Bircsak, Elizabeth Yen, Xia Wen, Mei-Juan Tu, Ai-Ming Yu, Nicholas P. Illsley, Stacy Zamudio, Lauren M. Aleksunes
Article
Engineering, Biomedical
Cassidy Blundell, Yoon-Suk Yi, Lin Ma, Emily R. Tess, Megan J. Farrell, Andrei Georgescu, Lauren M. Aleksunes, Dongeun Huh
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Pharmacology & Pharmacy
Kristin M. Bircsak, Jamie E. Moscovitz, Xia Wen, Faith Archer, Poi Yu Sofia Yuen, Moiz Mohammed, Naureen Memon, Barry I. Weinberger, Laura M. Saba, Anna M. Vetrano, Lauren M. Aleksunes
DRUG METABOLISM AND DISPOSITION
(2018)
Meeting Abstract
Pharmacology & Pharmacy
Lauren M. Aleksunes
DRUG METABOLISM AND PHARMACOKINETICS
(2018)
Article
Pharmacology & Pharmacy
Mustafa E. Ibrahim, Cara Chang, Yichun Hu, Susan L. Hogan, Nickie Mercke, Madeleine Gomez, Cindy L. O'Bryant, Daniel W. Bowles, Blessy George, Xia Wen, Brian Buckley, Lauren Aleksunes, Melanie S. Joy
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Obstetrics & Gynecology
Naureen Memon, Ian J. Griffin, Chris W. Lee, Aimee Herdt, Barry Weinberger, Thomas Hegyi, Mary O. Carayannopoulos, Lauren M. Aleksunes, Grace L. Guo
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
John Rooney, Keiyu Oshida, Naresh Vasani, Beena Vallanat, Natalia Ryan, Brian N. Chorley, Xuting Wang, Douglas A. Bell, Kai C. Wu, Lauren M. Aleksunes, Curtis D. Klaassen, Thomas W. Kensler, J. Christopher Corton
Article
Pharmacology & Pharmacy
John T. Szilagyi, Karma C. Fussell, Yun Wang, Yi-Hua Jan, Vladimir Mishin, Jason R. Richardson, Diane E. Heck, Shaojun Yang, Lauren M. Aleksunes, Debra L. Laskin, Jeffrey D. Laskin
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Blessy George, Xia Wen, Edgar A. Jaimes, Melanie S. Joy, Lauren M. Aleksunes
Summary: Research indicates that among five 5-HT3 antagonist drugs, ondansetron shows the strongest inhibitory effect on the OCT2 and MATE1 transporters, significantly impacting the transport of ASP(+) in cell experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Carolyn W. Kinkade, Zorimar Rivera-Nunez, Ludwik Gorcyzca, Lauren M. Aleksunes, Emily S. Barrett
Summary: Research suggests that mycotoxins like Zearalenone can have adverse effects on the female reproductive system, including infertility, ovarian disorders, and pregnancy complications.
Article
Pharmacology & Pharmacy
B. George, X. Wen, N. Mercke, M. Gomez, C. O'Bryant, D. W. Bowles, Y. Hu, S. L. Hogan, M. S. Joy, L. M. Aleksunes
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2017)