Journal
WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY
Volume 17, Issue 1, Pages 1-5Publisher
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/wo.2013.33765
Keywords
gastric cancer; Notch; miR-34; COX-2; gamma-secretase inhibitors
Categories
Ask authors/readers for more resources
Notch signaling pathway is activated dynamically during evolution playing significant role in cell fate determination and differentiation. It has been known that alterations of this pathway may lead to human malignancies, including gastric cancer. Despite a decline in the overall incidence, this disease still remains an important global health problem. Therefore, a better understanding of the molecular alterations underlying gastric cancer may contribute to the development of rationally designed molecular targeted therapies. It has been reported that Notch1 receptor could become a-prognostic marker of gastric cancer and novel target for gastric cancer therapy. Among the novel and targeted approaches for the treatment of gastric cancer is also the process of Notch receptors regulation by specific microRNA. gamma-secretase inhibitors are also taken into consideration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available