Review
Biochemistry & Molecular Biology
Hubert Aleksandrowicz, Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Summary: The prevalence of venous leg ulcers (VLUs) ranges from 1.5% to 3% in the general population, with common challenges being recurrence and resistance to healing. New technologies, such as biophysical interventions and advanced wound therapies, have been increasingly used in treating VLUs in recent years.
Review
Dermatology
Jodi Christine McDaniel, Bohyun Kim, Dina Rose McGowan
Summary: Determining the role of molecular factors in venous leg ulcer exudate is crucial for identifying biomarkers that can guide treatment. However, there is no standardized approach for collecting, processing, and storing wound fluid samples. This scoping review identified heterogeneous methods used in studies of venous leg ulcers and highlighted the need for standardized sampling methods to facilitate accurate comparisons and rapid determination of biomarkers.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Olga Krizanova, Adela Penesova, Alica Hokynkova, Andrea Pokorna, Amir Samadian, Petr Babula
Summary: Chronic venous disease is a condition that affects the veins in the lower extremities, characterized by impaired blood return. This review discusses the etiology, risk factors, and pathophysiology of venous leg ulcers (VLU), and compares the treatment options.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Klaus Kirketerp-Moller, Petra Doerfler, Nicole Schoefmann, Barbara Wolf-Winiski, Omid Niazi, Vibeke Pless, Tonny Karlsmark, Magnus Agren
Summary: This exploratory study aimed to investigate the association between biomarkers in wound fluid and the healing of split-thickness skin grafts in venous leg ulcers. The study found that the concentration of matrix metalloproteinase-9 in wound fluid was higher in venous leg ulcers showing good healing compared to those with poor healing.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Public, Environmental & Occupational Health
Natalie Shi Qi Wong, Audrey Hui Min Tan, Kai Siang Chan, Karine C. C. Goh, Peiting Lai, Sivakami Muthuveerappa, Mohamed Maliki Bin Mohamed Nasir, Shanying Liang, Qiantai Hong, Enming Yong, Zhiwen Joseph Lo
Summary: This study examined the effect of sequential therapy with TLC-Ag and TLC-NOSF on the wound healing and quality of life of patients with VLUs. The results demonstrated that sequential therapy resulted in significant reduction in wound area, improved healing, and enhanced quality of life for the patients.
HEALTH SCIENCE REPORTS
(2023)
Article
Dermatology
Khi Yung Fong, Tina Peiting Lai, Kai Siang Chan, Isabel Jia Le See, Cheng Cheng Goh, Sivakami Muthuveerappa, Audrey Huimin Tan, Shanying Liang, Zhiwen Joseph Lo
Summary: The study aims to validate the accuracy of a smartphone wound application in Asian patients with venous leg ulcers. The results show that Tissue Analytics application is a useful adjunct for wound assessment and surveillance in this population.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Barakat Abdelreheem Mahmood, Emad Hussein ElSayed, Salah M. Abd Elghany, Dina Farouk Elnaggar, Hoda A. A. Youssef, Saber M. Abdelmaksoud
Summary: A new powder dressing was found to be effective in managing chronic venous ulcers, with higher healing rates, shorter duration to healing, and lower pain.
DERMATOLOGIC SURGERY
(2023)
Article
Infectious Diseases
Ilaria Cavallo, Ilaria Lesnoni La Parola, Francesca Sivori, Luigi Toma, Tatiana Koudriavtseva, Isabella Sperduti, Daniela Kovacs, Giovanna D'Agosto, Elisabetta Trento, Norma Cameli, Anna Mussi, Alessandra Latini, Aldo Morrone, Fulvia Pimpinelli, Enea Gino Di Domenico
Summary: This study analyzed clinical data and laboratory parameters of patients with infected and noninfected chronic venous leg ulcers (VU). The results showed that infected ulcers had increased size and depth and higher levels of inflammatory cytokines. Hyperhomocysteinemia was more common in infected ulcers, and Gram-negative bacteria and strong biofilm producers were predominant in the infection.
Review
Medicine, General & Internal
C. D. Weller, Victoria Team, Sebastian Probst, Georgina Gethin, Catelyn Richards, Jane Sixsmith, Louise Turnour, Ayoub Bouguettaya
Summary: This scoping review aims to examine the level of health literacy in VLU patients and how it may link to self-management behaviors, particularly exercise and compression adherence, and their overall VLU healing.
Article
Dermatology
Vincent Maida, Runjie Bill Shi, Francesco Gabriele Tatangelo Fazzari, Lydia Zomparelli
Summary: Venous leg ulcers, a common lower limb wound, are difficult to heal even with evidence-based compression therapies. Topical Cannabis-Based Medicines show promise in promoting wound closure for complex patients with these ulcers, but further controlled trials are needed.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Medicine, General & Internal
Cibele T. D. Ribeiro, Fernando A. L. Dias, Guilherme A. F. Fregonezi
Summary: The effectiveness of hydrogel dressings for treating venous leg ulcers remains uncertain. More research is needed to determine the efficacy of hydrogel dressings compared to gauze and saline, alginate dressing, manuka honey, or hydrocolloid in promoting the healing of venous leg ulcers.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Dermatology
Kai Siang Chan, Shanying Liang, Yuan Teng Cho, Yam Meng Chan, Audrey Hui Min Tan, Sivakami Muthuveerappa, Tina Peiting Lai, Cheng Cheng Goh, Annie Joseph, Qiantai Hong, Enming Yong, Li Zhang, Lester Rhan Chaen Chong, Glenn Wei Leong Tan, Sadhana Chandrasekar, Zhiwen Joseph Lo
Summary: The study investigated the intra- and inter-rater reliability of the WA imaging system in patients with venous leg ulcers, demonstrating high reliability of the system and excellent consistency with traditional measurement methods.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Dermatology
Nuraini Nazeha, Jia Yi Lee, Seyed Ehsan Saffari, Lingyan Meng, Pei Ho, Yi Zhen Ng, Nicholas Graves
Summary: Healthcare costs arising from venous leg ulcers (VLU) are expected to increase. This study estimated the healthcare resources incurred by VLU patients and examined the predictors explaining variation in cost-related outcomes.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Materials Science, Paper & Wood
Nghi Thi-Phuong Nguyen, Huy Hoang Nguyen, Hoan Ngoc Doan, Kien Trung Pham, Khiem Van Nguyen, Binh Thanh Vu, Tin Dai Luong, Bach Thang Phan, Hanh Kieu Thi Ta, Ngoc Quyen Tran, Tuan-Ngan Tang, Nhi Ngoc-Thao Dang, Thi-Hiep Nguyen
Summary: The study found that adding chitosan oligosaccharide to bacterial cellulose membranes can improve their hemostatic properties, although it may decrease the mechanical strength of the membranes. The modified bacterial cellulose membrane with 2 w/v% chitosan oligosaccharide solution (BC-COS2) demonstrated excellent hemostasis promotion in in vitro and in vivo experiments.
Review
Medicine, General & Internal
Niamh E. M. McLain, Zena E. H. Moore, Pinar Avsar
Summary: This study aimed to evaluate the effects of wound cleansing, wound cleansing solutions and wound cleansing techniques for treating venous leg ulcers. Four studies including 254 participants were analyzed, but with insufficient evidence to demonstrate the effectiveness of different cleansing solutions in treating venous leg ulcers.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Dermatology
W. G. Philipp-Dormston, G. Sanclemente, L. Torezan, M. Tretti Clementoni, A. Le Pillouer-Prost, H. Cartier, R. M. Szeimies, P. Bjerring
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2016)
Article
Dermatology
Martine Baspeyras, Jean-Marie Dallara, Hugues Cartier, Marie-Helene Charavel, Laurent Dumas
JOURNAL OF COSMETIC DERMATOLOGY
(2017)
Article
Dermatology
Doris Hexsel, Hugues Cartier, Per Heden, Henry Delmar, Per Bergentz, Fernanda Camozzato, Carolina Siega, Cecilia Skoglund, Carolina Edwartz, Diane Rees, Philippe Kestemont
DERMATOLOGIC SURGERY
(2018)
Article
Surgery
Berthold-Josef Rzany, Benjamin Ascher, Rui L. Avelar, Jesper Bergdahl, Vince Bertucci, Isaac Bodokh, James Alastair Carruthers, Hugues Cartier, Henry Delmar, Ralf Denfeld, John E. Gross, Marc Heckmann, Per Heden, Said Hilton, Christopher Inglefield, Patricia Ogilvie, Gerhard Sattler, Michael Sebastian, Nowell Solish, Arthur Swift, Patrick Trevidic
AESTHETIC SURGERY JOURNAL
(2020)
Article
Dermatology
Hugues Cartier, Per Heden, Henry Delmar, Per Bergentz, Cecilia Skoglund, Carolina Edwartz, Maria Norberg, Philippe Kestemont
DERMATOLOGIC SURGERY
(2020)
Letter
Dermatology
C. Maire, A. S. Vignion-Dewalle, H. Cartier, S. Mordon
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Dermatology
F. Philibert, V. Gras-Champel, G. Chaby, F. Plantier, H. Cartier, O. Cogrel, E. Carmi
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
(2020)
Letter
Dermatology
Adele de Masson, Jean-David Bouaziz, Luc Sulimovic, Charles Cassius, Marie Jachiet, Marius-Anton Ionescu, Michel Rybojad, Martine Bagot, Tu-Anh Duong
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Letter
Dermatology
Michael Naouri, Annabel Maruani, Sylvie Lagrange, Olivier Cogrel, Amandine Servy, Anne Marie Collet Vilette, Sabrina Fourcade, Nathalie Gral, Yvon Perrillat, Regine Bousquet Rouaud, Hugues Cartier, Cyril Maire, Dominique Boineau, Gerard Toubel, Isabelle Ollivier, Anne Le Pillouer-Prost, Thierry Passeron
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Inna Kogan, Pavel Korolik, Hugues Cartier, Hertsel Adhoute, Alexander Liberzon
JOURNAL OF COSMETIC DERMATOLOGY
(2020)
Letter
Dermatology
Nicolas Kluger, Ashraf Badawi, Hans-Joachim Laubach, Albert Wolkerstorfer, Hugues Cartier
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
F. Braccini, I. Catoni, F. Belfkira, J. Lagier, E. Roze, J. Paris, J. Huth, V. Bronsard, H. Cartier, M. David, O. Galatoire, D. Obadia, H. Sabatier, E. Sarfati, P. Kestemont, C. Winter, A. Redaelli
Summary: This study summarizes that the safety and efficacy of BoNTA treatments have been established, but there are ongoing developments in injection techniques, target muscles, and toxin doses to improve treatment outcomes. The recommendations emphasize tailoring treatments based on individual muscle activity patterns and patient preferences.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Per Heden, Doris Hexsel, Hugues Cartier, Per Bergentz, Henry Delmar, Fernanda Camozzato, Carolina Siega, Cecilia Skoglund, Carolina Edwartz, Maria Norberg, Philippe Kestemont
JOURNAL OF DRUGS IN DERMATOLOGY
(2019)
Article
Dermatology
Ravi Jain, Gerardo Moreno Arias, Pablo Naranjo, Max Murison, Jose Luis Lopez Estebaranz, Alma Fratila, Welf Prager, Carlos Guillen Barona, Michael Weidmann, Serge Dahan, Hugues Cartier, Gerhard Sattler, Maurizio Podda
JOURNAL OF DRUGS IN DERMATOLOGY
(2018)
Article
Dermatology
C. Noe, M. Pelletier-Aouizerate, H. Cartier
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
(2017)